Fertility potential in a cohort of 65 men with previously acquired undescended testes

Brakel, J. van; Kranse, Ries; Keizer‐Schrama, Sabine M.P.F. de Muinck; Hendriks, Emile; Jong, Frank H. de; Hack, W. W. M.; Voort-Doedens, L.M. van der; Bangma, Chris H.; Hazebroek, F. W. J.; Dohle, Gert R.

doi:10.1016/j.jpedsurg.2013.09.020

Cited by 35 publications

(29 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The percentage of men participating in our study is 21.7% for the entire analysis. This is comparable to other studies ranging from 11.3% to 28.0% (Adomaitis, ; van Brakel, ; Trsinar, ). Several factors influence the response rate of long‐term studies like ours, generally negatively due to untraceable potential participants or outdated medical charts.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques

et al. 2018

View full text Add to dashboard Cite

| INTRODUC TI ONBilateral undescended testes (BUDT) are associated with subfertility, which orchidopexy in early childhood aims to prevent. According to the literature, not treating BUDT results in azoospermia in 80% of men, whilst treatment reduces this to 7%-43% (Bellinger, 1989;Cendron, 1989;Cortes, 2001;Dadfar, 2007;Hoseinpour, 2015;Werder, 1976). Men with BUDT are less likely to father children. Only 62% will succeed within 12 months compared to 94% in healthy agematched controls (Lee, 1997). This lower fertility potential is also reflected in a decreased sperm concentration of 5.2 × 10 6 /ml in men with BUDT versus 82.4 × 10 6 /ml in controls (Lee, 1997).The technique for the preparation of the testis and the way to perform the fixation in the scrotum in relation to later fertility potential has not been thoroughly investigated. Animal studies have shown the presence of spermatogenesis in 71% of cases when using a suture through the tunica albuginea as fixation compared to 94% when using a tunica dartos pouch. Also, increased tubular atrophy was seen in 58% versus 23% respectively (Bellinger, 1989). The two techniques were evaluated for an effect on testicular volume in 69 AbstractTo evaluate fertility potential after orchidopexy for bilateral undescended testis and compare two surgical fixation techniques for effect on fertility. Men older than 22 years who had either tunica albuginea orchidopexy (TAO) or "no-touch" technique (NTO) in childhood for bilateral undescended testis (BUDT) were selected.Participants filled out a questionnaire followed by physical examination, had testicular ultrasound, blood sample and semen analysis. Statistical testing was performed using general linear modelling. Sixty-seven out of 166 individuals responded. Fortynine completed the questionnaire, and nine (18.3%) reported having fathered children. Thirty-six showed up for further examination, 26 had TAO and 10 NTO. Impaired hormonal spermatogenesis regulation (34.6% vs. 20%), higher subfertility rate (46% vs. 20%) and lower means of motile spermatozoa (58.1 × 10 6 spz vs.177.9 × 10 6 spz) were observed in the TAO versus the NTO group; none of these were statistically significant. Four (15.4%) of the TAO and two (20%) of the NTO group have azoospermia. Although the operation technique did not have a significant impact on fertility, unfavourable outcomes were more common after surgery involving the tunica albuginea of the testis. Larger sample sizes are needed to ascertain whether the trends favouring the NTO technique are of any significance. K E Y W O R D Sbilateral undescended testes, fertility, fixation technique, orchidopexy, semen analysis

show abstract

Section: Discussionsupporting

confidence: 92%

“…Older studies tend to report low paternity rates in up to 14.3% (Werder, ), which could be due to a different reporting method. More recent studies, which do specify this, usually define it as attempting fatherhood for 12 months and report success in 44%–62% of cases (Lee, ; van Brakel, ). This is still low compared to our average of 82%.…”

Section: Discussionmentioning

confidence: 99%

Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques

et al. 2018

View full text Add to dashboard Cite

show abstract

“…and possibly hormonal treatment in case of bilateral cryptorchidism (Hadziselimovic et al ., ; Bilius et al ., ). This seems to be a logical step forward as surgery alone has a limited effect in patients with bilateral cryptorchidism, and the risk of infertility is higher in this group compared with patients who have unilateral cryptorchidism (Engeler et al ., ; van Brakel et al ., ). Moreover, there are studies showing improved fertility parameters in adults after adjuvant hormonal treatment with luteinising hormone‐releasing hormone analogs (Hadziselimovic, ).…”

Section: Discussionmentioning

confidence: 97%

Consequences of bilateral cryptorchidism in adults

et al. 2016

View full text Add to dashboard Cite

Bilateral cryptorchidism treatment results are often shadowed by the majority of unilateral cases. We report the long-term follow-up results of boys treated for bilateral cryptorchidism during childhood. Patients treated in two main paediatric surgery centres were selected from medical registries and invited for a clinical examination including scrotal ultrasound, salivary testosterone measurement and a semen sample. Thirty-six men (38.3%) replied to the written invitation, and 21 agreed to be examined. The mean age at orchidopexy was 74 months (range 24-138). Sperm count was 0.42 × 10 (SD ± 0.64 × 10 ) ml . The correlation between total testicular volume and total sperm count was statistically significant (r = 0.481; P = 0.032). These results show that surgical treatment of bilateral cryptorchidism after the age of 2 years does not prevent infertility. Sperm count and endocrine evaluation advocated after the treatment of bilateral cryptorchidism in all adult patients.

show abstract

“…This information is crucial for the healthcare provider when counseling these kinds of patients. Another significant finding in this study was the unremarkable difference between the use of random biopsy (TESE) and Micro-TESE [12] as it yielded the same results in all patients that underwent the sperm extraction techniques. Hinting towards the absence of superiority of Micro-TESE in these patients, which needs to be further investigated using a larger sample size in future research.…”

Section: Discussionmentioning

confidence: 61%

Chances of Sperm Retrieval during Testicular Sperm Extraction in Adult Cryptorchid Testes

Alhathal¹

2017

UNOAJ

View full text Add to dashboard Cite

show abstract

Fertility potential in a cohort of 65 men with previously acquired undescended testes

Cited by 35 publications

References 30 publications

Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques

Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques

Consequences of bilateral cryptorchidism in adults

Chances of Sperm Retrieval during Testicular Sperm Extraction in Adult Cryptorchid Testes

Contact Info

Product

Resources

About