Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology?

Gilbert, Kirven; Nangia, Ajay K.; Dupree, James M.; Smith, James F.; Mehta, Akanksha

doi:10.1016/j.urolonc.2017.11.002

Cited by 53 publications

(41 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although similar systematic reviews have been published (Ferrari et al, ; Gilbert, Nangia, Dupree, Smith, & Mehta, ), this distinctive review focuses on the role of the healthcare provider and the healthcare system itself rather than patient‐dependent outcomes such as the use rate of frozen spermatozoa (Ferrari et al, ) or the cost‐effectiveness of fertility preservation in testicular cancer patients (Gilbert et al, ).…”

Section: Discussionmentioning

confidence: 99%

Semen cryopreservation in adolescent and adult men undergoing fertility compromising cancer treatment: A systematic review

et al. 2019

View full text Add to dashboard Cite

Treatment‐related infertility is a common problem in cancer survivors. Semen cryopreservation is the most established option for male oncological patients wishing to preserve their fertility. We conducted a systematic review to analyse the existing literature regarding the frequency of offers and attempts of semen cryopreservation. We systematically searched MEDLINE and EMBASE for eligible literature without restrictions to language, study type or year of publication. Two authors independently screened and evaluated the citations for eligibility. Studies were included if they reported on pubertal or post‐pubertal patients at risk of fertility impairment prior to their cancer therapy. We excluded studies neither reporting the prevalence of offer nor attempt of semen cryopreservation. Possible factors for heterogeneity between the studies were examined by meta‐regression analyses. Out of 6,105 returned citations, 42 studies were included in the analysis. The prevalence of offer varied from 8% to 100% and corresponding attempts ranged from 3% to 79%, showing a vast heterogeneity with inconsistent reporting of influencing variables. Measured by the number of scientific publications, the awareness for fertility preservation is increasing while actual prevalences are diverse. In order to identify variables influencing offer and attempt prevalences, consistent reporting of a core set of factors is required.

show abstract

Section: Discussionmentioning

confidence: 99%

Semen cryopreservation in adolescent and adult men undergoing fertility compromising cancer treatment: A systematic review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Sibert et al [6] was reported that semen quality did not differ significantly in patients who cryopreserved sperm before or after orchidectomy. But it should preferably be performed before orchiectomy [7]. Also, in young boys who was performed orchiectomy and planned to chemotherapy, testicular tissue cryopreservation may be preferred [8].…”

Section: Discussionmentioning

confidence: 99%

What Is the Significance of Rete Testis Invasion by Malign Germ Cell Tumor and Does Hilum Predict Metastasis?

Ediz¹,

İhvan²

2019

Urol Int

View full text Add to dashboard Cite

Background: The significance of hilar soft tissue invasion of rete testis in malign germ cell tumors is still controversial on current guidelines. Objectives: We aimed to investigate the importance of hilar soft tissue involvement in germ cell tumors and evaluated the possibility of a risk factor such as rete testis. Method: Totally, 59 radical orchiectomy specimens operated between 2007 and 2015 at our clinics. All records were retrospectively researched. Patients’ age, level of tumor markers, tumor size, histological subtype, clinical stage, presence or absence of carcinoma in situ, vascular/lymphatic and/or hilar soft tissue invasion, tumoral necrosis, number, site and diameter of metastasis, type of further treatment (radiotherapy or chemotheraphy) and follow-up period were recorded and evaluated for all patients. Results: Twenty-six of totally 59 malign germ cell tumors were seminomatous and 33 were nonseminomatous (NS). Mean patients age was 38.54 years (range 17–89 years). Mean follow-up duration was 39.84 months (range 3–96). Serum tumor marker levels were found associated with rete testis invasion (p = 0.035). Hilar soft tissue invasion was significantly associated with vascular invasion (p = 0.001). As it was expected, vascular invasion was significantly associated with metastasis (p = 0.024). Conclusions: We concluded that there is a strong association between hilar soft tissue invasion and vascular invasion. Especially in NS germ cell tumors, hilar soft tissue involvement a risk factor for prognosis and to determine the need for additional treatment. According to our study, hilar soft tissue status should be reported on routine pathology report.

show abstract

“…[10,[56][57][58][59][60][61] Machen ve ark.nın çalışmalarındaki %1,5'lik sperm kullanma oranı ABD'deki diğer çalışmalarda %5-10 arasında bildirilmiştir. [10,32,62] Japonya'da 695 enstitüyü içeren bir araştırmada spermleri dondurulup saklanan toplam 820 kanser olgusunda sperm dondurmanın kullanılmamasının temel sebepleri azoospermi ve kötü semen parametreleri olarak belirtilmiştir. [13] Toplam 898 kanserli olguda dondurulmuş sperm kullanma oranları ise %10,7 olarak bildirilmiştir.…”

Section: öZunclassified

“…Yine sperm saklanmasının radyoterapi ve kemoterapi öncesi testiküler sperm ekstraksiyonu (TESE) ve benzerlerine göre maliyet açısından oldukça avantajlı olduğu belirtilmiştir. [62] Dondurulup ısıtılan spermde gebelik ilk kez 1953 yılında bildirilmiştir. [66] Sperm saklanması sonrası gebelik oranları %12-35,2 arasında değişmektedir.…”

Section: öZunclassified

Sperm dondurma: Güncel gelişmeler

Erdemır¹

2019

Androl Bul

View full text Add to dashboard Cite

F ertilite için gerekli olan spermin bazı durumlarda sınırlı olarak elde edildiği ya da gelecekte azalacağı bilindiği için spermin gerektiğinde kullanılmak üzere dondurularak saklanması gündeme gelmiştir. Fertilite ile ilişkili mücadele ve gayretler çiftlerin ruh sağlığını bozduğu için bu stresi azaltabilmesi açısından da sperm dondurma işlemi büyük önem arzetmektedir. [1,2] İlk olarak 1940'lı yıllarda veteriner hekimler tarafından uygulanan sperm dondurma işlemi spermlerin-80°C ile-196°C arasında gerektiğinde tekrar kullanılmak üzere saklanmasını içermekte olup insanlarda 1950'li yıllardan beri yapılmaktadır. [3] Başlangıçta kullanımı sadece intrauterin inseminasyon (IUI) için sınırlı olan sperm dondurma ile ilişkili endikasyonlar günümüzde ol-ABSTRACT Sperm cryopreservation involves the cooling of semen samples and their storage at-196°C in liquid nitrogen. This technique has been used widely since the 1960s to treat couples with infertility. Cancer is the major indication for sperm cryopreservation. However currently, the scope of clinical indications used for sperm cryopreservation has expanded widely. In this context, sperm cryopreservation is used in patients with retrograde ejaculation, severe olgoospermia, metabolic disorders, spinal cord injury, cranial tumors. Cryopreservation process involves cooling, freezing, and thawing steps. Cryopreservation of sperm may negatively affect on membrane lipid composition, acrosome status, sperm motility, vitality and DNA damage. To prevent of this negative effects several cryoprotectants have been used. In general the pregnancy rates after sperm cryopreservation are changes between 12% and 35.2%. In this review current advances have been evaluated in the era of sperm cryopreservation.

show abstract

Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology?

Cited by 53 publications

References 60 publications

Semen cryopreservation in adolescent and adult men undergoing fertility compromising cancer treatment: A systematic review

Semen cryopreservation in adolescent and adult men undergoing fertility compromising cancer treatment: A systematic review

What Is the Significance of Rete Testis Invasion by Malign Germ Cell Tumor and Does Hilum Predict Metastasis?

Sperm dondurma: Güncel gelişmeler

Contact Info

Product

Resources

About