Fertilization rate in couples with unexplained infertility

Mackenna, Antonio; Zegers‐Hochschild, Fernando; Fernández, E.; Fabres, Cecilia; Huidobro, Christian; Prado, Juliana Alvarenga; Roblero, L; Altieri, Elena; Guadarrama, Alejandro; López, Tigmaza

doi:10.1093/oxfordjournals.humrep.a137621

Cited by 19 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total fertilization failure or lower fertilization rates in unexplained infertility after IVF has been a concern (13)(14)(15)(16). Performing ICSI and IVF on sibling oocytes has been recommended to prevent total fertilization failure and diagnose the sperm fertilizing ability for the management of future cycles (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Untitled

Jaroudi

Al-Hassan

Al-Sufayan

et al. 2003

Journal of Assisted Reproduction and Genetics

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Untitled

Jaroudi

Al-Hassan

Al-Sufayan

et al. 2003

Journal of Assisted Reproduction and Genetics

View full text Add to dashboard Cite

show abstract

“…Of the remaining 375 papers, 117 did not classify a definition of unexplained infertility. As a result, a total of 258 primary research papers with full text available were included …”

Section: Resultsmentioning

confidence: 99%

The definition of unexplained infertility: A systematic review

Raperport,

Desai,

Qureshi

et al. 2023

BJOG

View full text Add to dashboard Cite

BackgroundThere is no consensus on tests required to either diagnose unexplained infertility or use for research inclusion criteria. This leads to heterogeneity and bias affecting meta‐analysis and best practice advice.ObjectivesThis systematic review analyses the variability of inclusion criteria applied to couples with unexplained infertility. We propose standardised criteria for use both in future research studies and clinical diagnosis.Search strategyCINAHL and MEDLINE online databases were searched up to November 2022 for all published studies recruiting couples with unexplained infertility, available in full text in the English language.Data collection and analysisData were collected in an Excel spreadsheet. Results were analysed per category and methodology or reference range.Main resultsOf 375 relevant studies, only 258 defined their inclusion criteria. The most commonly applied inclusion criteria were semen analysis, tubal patency and assessment of ovulation in 220 (85%), 232 (90%), 205 (79.5%) respectively. Only 87/220 (39.5%) studies reporting semen analysis used the World Health Organization (WHO) limits. Tubal patency was accepted if bilateral in 145/232 (62.5%) and if unilateral in 24/232 (10.3%). Ovulation was assessed using mid‐luteal serum progesterone in 115/205 (56.1%) and by a history of regular cycles in 87/205 (42.4%). Other criteria, including uterine cavity assessment and hormone profile, were applied in less than 50% of included studies.ConclusionsThis review highlights the heterogeneity among studied populations with unexplained infertility. Development and application of internationally accepted criteria will improve the quality of research and future clinical care.

show abstract

“…O n the basis of these clinical data, the results obtained with GIFT by Cefalu et al, (1988) could be explained by the chances of achieving fertilization being greater when multiple oocytes are exposed to spermatozoa (Mackenna et al, 1992b), and not necessarily because abnormal sperm transport is bypassed. This suggestion is supported by results obtained (32.6% pregnancy rate per cycle) using induction of multiple follicular development combined with IUI in couples with unexplained infertility (Chaflkin et al, 1991).…”

Section: Sperm Transportmentioning

confidence: 99%

“…In-vitro fertilization (IVF) rates in stimulated cycles are significantly lower in couples with unexplained infertility in comparison with patients having tuba1 problems, although semen parameters are within the normal range in both groups (Mackenna et al, 1992b). Similar results have also been obtained in couples undergoing IVF in a natural cycle (Mackenna et al, 1992c), suggesting that the lack of fertilization in couples with unexplained infertility is due to intrinsic gamete defects and not necessarily to abnormalities in the follicular phase of the menstrual cycle.…”

Section: Sperm Functionmentioning

confidence: 99%

Contribution of the male factor to unexplained infertility: a review

Mackenna

1995

Int J of Andrology

View full text Add to dashboard Cite

The more exhaustive the evaluation of couples with unexplained infertility, the more likely is the opportunity for detecting the aetiological factor responsible for infertility. Transport of spermatozoa through the upper genital tract and their ability to fertilize the oocyte are two obscure areas for the conventional evaluation of infertility. Although research in the former area is limited, there is indirect evidence that impaired sperm transport could be one of the causes of infertility in some couples with otherwise unexplained infertility. on the other hand, the availability of sperm function tests and the correlation of their results with in-vitro fertilization rates have allowed the detection of a previously hidden male factor in couples with unexplained infertility. It has been demonstrated that couples suffering unexplained infertility have significantly lower in-vitro fertilization rates in comparison with patients with tubal problems. These results can be explained because of several case control studies in patients with unexplained infertility have reported defects in capacitation and sperm motion characteristics, binding of the spermatozoa to the zone pellucida, acrosome reaction, acrosin activity of the spermatozoa, and the ability of the spermatozoa to penetrate zona-free hamster oocytes. These observations suggest that methods for assessing the fertilizing capacity of the spermatozoa have to incorporated in the evaluation of couples with unexplained infertility in order to amplify the scope of the workup and to better decide the appropriate treatment for these couples.

show abstract

Fertilization rate in couples with unexplained infertility

Cited by 19 publications

References 0 publications

Untitled

Untitled

The definition of unexplained infertility: A systematic review

Contribution of the male factor to unexplained infertility: a review

Contact Info

Product

Resources

About