Ferulic acid and PDMS modified medical carbon materials for artificial joint prosthesis

Abstract

Medical carbon material has been extensively studied due to their excellent biological and mechanical properties. However, the dissociation of the surface carbon particles greatly limited the application of medical carbon material (MCM). To overcome this defect, we introduced the polydimethylsiloxane, a polymer-coating material (PCM) that possesses acceptable biocompatibility, into medical carbon material to prevent the shedding of carbon debris. Additionally, to reduce inflammatory reactions and increase surface hydrophilicity, ferulic acid, also called Chinese medicine coating material (CCM), was used to modify the surface of polymer-coating material. We investigated the proliferation and adhesion of NIH-3T3 cells onto MCM, PCM and CCM in vitro. We showed that CCM exhibited excellent biological activity to promote cell growth. Twelve weeks after CCM implantation, bone defects were repaired, and the material showed acceptable chemical stability. The results indicated that the CCM composite possesses excellent mechanical property and favorable biocompatibility, which can be used for clinical bone repair.

Development of a Novel Electrochemical Biosensor Based on Carbon Nanofibers–Gold Nanoparticles–Tyrosinase for the Detection of Ferulic Acid in Cosmetics

“…FA is known as an antiaging [ 3 ], anti-inflammatory [ 4 ], antithrombotic [ 5 ], antidiabetic [ 6 ], antiulcerigen [ 7 ], antihemolitic [ 8 ], antiviral [ 9 ] and even anti-carcinogenic agent [ 10 ]. Due to the antibacterial effect, it may also be used in certain implants [ 11 ]. Ferulic acid plays an important role in the human body and is absorbed in the small intestine as a major metabolite of chlorogenic acids [ 12 , 13 ].…”

Silk and Silk Composite Aerogel-Based Biocompatible Triboelectric Nanogenerators for Efficient Energy Harvesting

“…Polydimethylsiloxane (PDMS) and polytetrafluoroethylene (PTFE) are ideal tribonegative materials for biocompatible TENGs. They are highly biocompatible and have been widely used in many medical devices. , However, tribopositive materials with high biocompatibility are rarely investigated. Kim et al developed a new butylated melamine formaldehyde polymer as a highly durable tribopositive material .…”

“…They are highly biocompatible and have been widely used in many medical devices. 27,28 However, tribopositive materials with high biocompatibility are rarely investigated. Kim melamine formaldehyde polymer as a highly durable tribopositive material.…”