Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells

Zhao, Jian; Suyama, Aki; Chung, Hsuan Lien; Fukuda, Toshihiko; Tanaka, Mitsuru; Matsui, Toshiro

doi:10.1016/j.lfs.2015.12.044

Cited by 15 publications

(9 citation statements)

References 27 publications

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“…Moreover, olive pits have cholinergic activity as demonstrated by the study of Cortés Castell et al ( 61 ) who determined the effect of a polyphenolic extract from olive pits on the development of the nervous system as well as its effect on pain induced by the neurotoxin kainic acid, taking the zebrafish as the animal model. Olive fruits are rich in dietary fibre and, overall, one of the most important compound is ferulic acid that has anti-inflammatory activity ( 62 ) . Suntar et al ( 63 ) have evaluated the anti-inflammatory and anti-nociceptive properties of leaves and fruits of Olea europaea L. (family Oleaceae) and the results revealed that ethanolic extract did not show a significant anti-inflammatory or analgesic activity, whereas the n -hexane extract displayed 12·7–27·8 % inhibition on the carrageenan-induced hind paw oedema model at the 400 mg/kg dose ( 63 ) .…”

Section: Resultsmentioning

confidence: 99%

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

et al. 2018

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Emerging literature suggests that diet constituents may play a modulatory role in chronic pain (CP) through management of inflammation/oxidative stress, resulting in attenuation of pain. We performed a narrative review to evaluate the existing evidence regarding the optimum diet for the management of CP, and we built a food pyramid on this topic. The present review also describes the activities of various natural compounds contained in foods (i.e. phenolic compounds in extra-virgin olive oil (EVO)) listed on our pyramid, which have comparable effects to drug management therapy. This review included 172 eligible studies. The pyramid shows that carbohydrates with low glycaemic index should be consumed every day (three portions), together with fruits and vegetables (five portions), yogurt (125 ml), red wine (125 ml) and EVO; weekly: legumes and fish (four portions); white meat, eggs and fresh cheese (two portions); red or processed meats (once per week); sweets can be consumed occasionally. The food amounts are estimates based on nutritional and practical considerations. At the top of the pyramid there is a pennant: it means that CP subjects may need a specific customised supplementation (vitamin B12, vitamin D, n-3 fatty acids, fibre). The food pyramid proposal will serve to guide dietary intake with to the intent of alleviating pain in CP patients. Moreover, a targeted diet can also help to solve problems related to the drugs used to combat CP, i.e. constipation. However, this paper would be an early hypothetical proposal due to the limitations of the studies.

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Section: Resultsmentioning

confidence: 99%

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

et al. 2018

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“…e mechanism of induction of nitric oxide by FA in cancer cells still needs to be evaluated. Nonetheless, FA was reported to generate nitric oxide through upregulation of argininosuccinate synthase in inflammatory human endothelial cells [60]. On the other hand, FA inhibits nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes [61].…”

Section: Discussionmentioning

confidence: 99%

2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90

Kamm

Przychodzeń

Kuban–Jankowska

et al. 2019

Journal of Oncology

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Melanoma is an aggressive type of skin cancer with one of the highest mortality rates. Notably, its incidence in the last few decades has increased faster than any other cancer. Therefore, searching for novel anticancer therapies is of great clinical importance. In the present study, we investigated the anticancer potential of 2-methoxyestradiol, potent chemotherapeutic, in the A375 melanoma cellular model. In order to furthermore evaluate the anticancer efficacy of 2-methoxyestradiol, we have additionally combined the treatment with a naturally occurring polyphenol, ferulic acid. The results were obtained using the melanoma A375 cellular model. In the study, we used MTT assay, flow cytometry, and western blot techniques. Herein, we have evidenced that the molecular mechanism of action of 2-methoxyestradiol and ferulic acid is partly related to the reduction of Hsp60 and Hsp90 levels and the induction of nitric oxide in the A375 melanoma cell model, while no changes were observed in Hsp70 expression after 2-methoxyestradiol and ferulic acid treatment separately or in combination. This is especially important in case of chemoresistance mechanisms because the accumulation of Hsp70 reduces induction of cancer cell death, thus decreasing antitumour efficacy.

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“…Numerous studies have attempted to investigate the role of NO and the associated enzymology expression following NF- κ B inhibition [ 52 – 55 ]. For example, Yang et al showed that inhibition of NF- κ B resulted in cytoprotective effects against sepsis in rat livers associated with CAT-2 mRNA downregulation [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Expression Profile of Cationic Amino Acid Transporters in Rats with Endotoxin-Induced Uveitis

Hsu

Chang

Yang

et al. 2016

Mediators of Inflammation

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Purpose. The transcellular arginine transportation via cationic amino acid transporter (CAT) is the rate-limiting step in nitric oxide (NO) synthesis, which is crucial in intraocular inflammation. In this study, CAT isoforms and inducible nitric oxide synthase (iNOS) expression was investigated in endotoxin-induced uveitis (EIU). Methods. EIU was induced in Lewis rats by lipopolysaccharide (LPS) injection. In the treatment group, the rats were injected intraperitoneally with the proteasome inhibitor bortezomib before EIU induction. After 24 hours, leukocyte quantification, NO measurement of the aqueous humor, and histopathological examination were evaluated. The expression of CAT isoforms and iNOS was determined by reverse transcription-polymerase chain reaction, western blotting, and immunofluorescence staining. Nuclear factor-kappa B (NF-κB) binding activity was evaluated by electrophoretic mobility shift assay. The mouse macrophage cell line RAW 264.7 was used to validate the in vivo findings. Results. LPS significantly stimulated iNOS, CAT-2A, and CAT-2B mRNA and protein expression but did not affect CAT-1 in EIU rats and RAW 264.7 cells. Bortezomib attenuated inflammation and inhibited iNOS, CAT-2A, and CAT-2B expression through NF-κB inhibition. Conclusions. CAT-2 and iNOS, but not CAT-1, are specifically involved in EIU. NF-κB is essential in the induction of CAT-2 and iNOS in EIU.

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Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells

Cited by 15 publications

References 27 publications

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90

Expression Profile of Cationic Amino Acid Transporters in Rats with Endotoxin-Induced Uveitis

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