Ferulic Acid Fatty Esters Synthesis: Physical and Biochemical Characteristics

Mustafa, Jaka Haris; Khan, SI; Ahmad, M. S.; Al‐Rehaily, Adnan J.; Khan, IA

doi:10.1055/s-0032-1307552

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“…This is in agreement with the literature [ 34 ]. According to previous studies, methyl ferulate demonstrated potential anti-inflammatory activity in lipopolysaccharide activated macrophage cells and was also proven to be equally active to ferulic acid with respect to antioxidant activity [ 35 , 36 ]. Compounds 5 and 11 demonstrated selective cytotoxic activity on colon and liver cell lines in our study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of Calotropis procera and Isolation of a New Lignan Glycoside

Al‐Taweel

Perveen

Fawzy

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Calotropis procera is traditionally used for treating many diseases including ulcers and tumors. It was thus deemed of interest to investigate and compare the antiulcer and cytotoxic activities of C. procera leaf, flower, and fruit extracts in an attempt to verify its traditional uses. Phytochemical studies on the fruits, flowers, and leaves of C. procera, collected from the desert of Saudi Arabia, led to the isolation of one new lignan 7′-methoxy-3′-O-demethyl-tanegool-9-O-β-d-glucopyranoside and five known compounds from the flowers, four compounds from leaves, and a flavonoid glycoside and a lignan glycoside from the fruits. The structures of compounds were determined by spectroscopic techniques. Ethanol extracts of the three parts of C. procera were evaluated for their antiulcer activity and we found that the leaf extract possessed a powerful antiulcer activity which could be considered as a promising drug candidate. All the extracts and the isolated compounds were evaluated for their cytotoxic activity against MCF-7, HCT-116, HepG-2, and A-549 human cancer cell lines. Compound 2 was highly active on all the cell lines, whereas compounds 5 and 11 were more selective on colon and liver cell lines. Compound 10 demonstrated a significant activity on liver and lung cancer cell lines.

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Section: Discussionmentioning

confidence: 99%