Ferulic Acid Modulates Fluoride-Induced Oxidative Hepatotoxicity in Male Wistar Rats

Abstract

The present study is aimed to evaluate the protective effect of ferulic acid (FA) on fluoride-induced oxidative hepatotoxicity in male Wistar rats. Fluoride (25 mg/L) was given orally to induce hepatotoxicity for 12 weeks. Hepatic damage were assessed using status of pathophysiological markers like serum marker enzymes like aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, gamma glutamyl transferase, lactate dehydrogenase, bilirubin, lipid profile, total protein content levels, and histopathological studies. Treatment with FA significantly reduced the degree of histological aberrations and rescued lipid peroxidation, as observed from reduced levels of lipid hydroperoxides, nitric oxide, restored levels of enzymic and non-enzymic antioxidants, and total protein content, with a concomitant decline in the levels of marker enzymes and lipid profile in fluoride-induced rats. These results suggest that ferulic acid has the ability to protect fluoride-induced hepatic damage.

Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: A possible mechanism

“…Alteration in the activities of hepatic functional marker enzymes such as AST, ALT, and γ‐GT are the direct indication of cellular and functional integrity of hepatic membranes. Our study reveals that fluoride intoxicated rats has increased hepatic marker enzyme activities that are in accordance with previous reports .…”

“…This could be one of the reasons for increasing serum fluoride level in fluoride treated rats. Fluoride crosses the cell membrane by simple diffusion and causes liver damage . Alteration in the activities of hepatic functional marker enzymes such as AST, ALT, and γ‐GT are the direct indication of cellular and functional integrity of hepatic membranes.…”

Ferulic acid: A natural compound as an efficient feed additive for GIFT (Oreochromis niloticus)

“…It was reported that ALP was involved in immune defence mechanisms and was correlated with the immune competence (Li et al., ). In studies on rats, the increase in ALP clearly exhibited that FA possessed promising hepato‐protective potential (Krishnan, Prasanna, Sabina, & Rasool, ; Panneerselvam, Subbiah, Arumugam, & Senapathy, ). The improvement of serum biochemistry parameters of FA‐supplemented groups in this study indicated that the tilapia might have better health status.…”

Single oral acute fluoride exposure causes changes in cardiac expression of oxidant and antioxidant enzymes, apoptotic and necrotic markers in male rats

“…Myocardial ROS, LPO, PCC and M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 16 NO are the hallmarks of oxidative insults triggered by various xenobiotics [30][31]. F -is known to induce oxidative stress that has been well demonstrated in several in vitro models [32][33] and in vivo chronic toxicity in experimental animals [34][35] and humans [16]. For the first time we report that acute F -toxicity impairs cardiac function through oxidative myocardial injury.…”