FET PET in the evaluation of indeterminate brain lesions on MRI: Differentiating glioma from other non-neoplastic causes – A pilot study

Reply to Letter to the Editor: “18F-FDOPA PET for the Noninvasive Prediction of Glioma Molecular Parameters: A Radiomics Study”

“…Figure 1 provides representative 18 F-FDOPA PET images of a brain inflammation case. Other dynamic amino acid PET studies also suggest that lymphomas (18) and benign lesions (19) show dynamic patterns similar to the ones observed in less aggressive gliomas. Dynamic PET imaging of brain lesions at the initial diagnosis, in addition to conventional static analysis (13), should therefore help identify nonglioma brain lesions.…”

18F‐FET PET maximum standard uptake value and WHO tumour classification grade in glioma

“…In the diagnostic setting, 18 F‐FET PET can identify both low‐grade and high‐grade brain tumours more accurately than 18 F‐FDG PET 4,5 . In patients with brain lesions of indeterminate nature on MRI, 18 F‐FET PET has shown a high positive predictive value aiding in clinical management 6 . The inability to distinguish between surgical changes, residual tumour and tumour recurrence is a major limitation of MRI.…”

“…4,5 In patients with brain lesions of indeterminate nature on MRI, 18 F-FET PET has shown a high positive predictive value aiding in clinical management. 6 The inability to distinguish between surgical changes, residual tumour and tumour recurrence is a major limitation of MRI. In treated brain tumours, 18 F-FET PET plays a significant role in detecting residual and recurrent disease.…”

Hybrid18F-FET PET and Perfusion MRI to Differentiate Disease Progression from Treatment-Related Changes in Malignant Brain Tumors

“…In Europe, 18 F-FET is the most frequently used amino acid tracer for brain tumor imaging, and especially in Germany, some centers have collectively performed more than 20,000 examinations because of the high clinical interest in this method (11,12). Furthermore, the increasing number of publications coming from Australia, China, India, and South Korea indicate a wide acceptance of this method (13)(14)(15)(16)(17). For 18 F-FET, approval exists in Switzerland (18) and in France (IASOglio; IASON).…”