Fetal anemia

Abbasi, Nimrah; Johnson, Jo-Ann; Ryan, Greg

doi:10.1002/uog.17555

Cited by 60 publications

(71 citation statements)

References 105 publications

(130 reference statements)

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“…Unfortunately, sonographic markers such as CTR, placental thickness, and MCA‐PSV are not sensitive enough for identifying all of the affected cases . Although MCA‐PSV has been accepted to be a gold standard for noninvasive screening of fetal anemia from other etiologies, the sensitivity of MCA‐PSV in screening of homozygous alpha thalassemia‐1 disease in the midtrimester was only 64.3% to 85.0% but with a high specificity of 98.6% to 100.0% . This may be explained by the fact that the used cutoff value above 1.5 MoM of MCA‐PSV, which is readily able to identify the moderately and severely anemic fetuses, is probably too high for mild anemia .…”

Section: Discussionmentioning

confidence: 99%

The best cutoff value of middle cerebral artery peak systolic velocity for the diagnosis of fetal homozygous alpha thalassemia‐1 disease

et al. 2019

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Objective To determine the best cutoff value of middle cerebral artery peak systolic velocity (MCA‐PSV) for the diagnosis of fetuses with homozygous alpha thalassemia‐1 disease. Methods Pregnancies at risk for fetal homozygous alpha thalassemia‐1 disease at 18 to 22 weeks were recruited. MCA‐PSV was measured before cordocentesis for hemoglobin typing and complete blood count. The performance of the MCA‐PSV for identifying affected fetuses was evaluated using a best cutoff value derived from the receiver operating characteristic (ROC) curve. Results Among 142 fetuses at risk, 46 (32.4%) fetuses were diagnosed as affected by homozygous alpha thalassemia‐1 disease and were categorized as mild anemia (16.3%), moderate anemia (58.1%), and severe anemia (25.6%). With the best cutoff point of MCA‐PSV > 1.30 multiples of the median (MoM) or >30.0 cm/s, the sensitivity for predicting fetal homozygous alpha thalassemia‐1 was 100%. Conclusions MCA‐PSV > 1.30 MoM is the best cutoff value for the diagnosis of all degrees of fetal anemia from homozygous alpha thalassemia‐1 fetuses. Because of its simplicity for interpretation and high efficacy, a cutoff value of MCA‐PSV > 30 cm/s can also be used as an alternative marker for fetal anemia screening during 18 to 22 weeks of gestation.

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Section: Discussionmentioning

confidence: 99%

The best cutoff value of middle cerebral artery peak systolic velocity for the diagnosis of fetal homozygous alpha thalassemia‐1 disease

et al. 2019

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“…The maternal antibodies can destruct fetal red blood cells and consequently cause fetal anemia, hydrops and perinatal death. 1,2 Intrauterine blood transfusion (IUT) is currently the only treatment option to prevent fetal death and reduce neurological impairment of these fetuses. 3 Although relatively safe in experienced hands, IUT remains an invasive procedure, and complications may occur.…”

Section: Introductionmentioning

confidence: 99%

Postponing Early intrauterine Transfusion with Intravenous immunoglobulin Treatment; the PETIT study on severe hemolytic disease of the fetus and newborn

Zwiers

Bom

Kamp

et al. 2018

American Journal of Obstetrics and Gynecology

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“…Die fetale Anämie ist ein eher seltenes Krankheitsbild, muss jedoch streng überwacht und in schweren Fällen präpartal therapiert werden [1] [9]. Es gibt verschiedene Schweregradeinteilungen.…”

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Sonografie in der Pränataldiagnostik

Finke¹

2019

Hebamme

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Der Ultraschall gilt als DAS diagnostische Werkzeug während der Schwangerschaft. Jede Schwangere wird mehrfach sonografisch untersucht, oft ohne weitere Reflexion. Doch ist das immer nur ein Segen? Dieser Artikel setzt sich kritisch mit den Vor- und Nachteilen der Ultraschalldiagnostik während der Schwangerschaft auseinander und liefert Hebammen Informationen zum Umgang mit verschiedenen Ultraschallbefunden.

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Fetal anemia

Cited by 60 publications

References 105 publications

The best cutoff value of middle cerebral artery peak systolic velocity for the diagnosis of fetal homozygous alpha thalassemia‐1 disease

The best cutoff value of middle cerebral artery peak systolic velocity for the diagnosis of fetal homozygous alpha thalassemia‐1 disease

Postponing Early intrauterine Transfusion with Intravenous immunoglobulin Treatment; the PETIT study on severe hemolytic disease of the fetus and newborn

Sonografie in der Pränataldiagnostik

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