Fetal Breathing Movements

Bocconi, Luisa; Boschetto, Chiara; Ceriani, Florinda; Kustermann, Alessandra

doi:10.1007/978-88-470-1402-2_5

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Thus, conditions affecting the volume of fetal lung fluid, be it through alterations in fluid secretion or other mechanisms, are likely to impact lung volume at birth. Another physiological event that influences lung volume is fetal breathing movements [79]. It has been shown in animal studies that elimination of fetal breathing movements leads to pulmonary hypoplasia [80].…”

Section: Human Lung Developmental Biologymentioning

confidence: 99%

Quantitative morphologic assessment of the newborn cystic fibrosis pig tracheal lobe

Adam¹

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I would also like to thank my thesis committee, members include Edwin Dove, Joe Reinhardt, Jessica Sieren, and David Stoltz. I owe a special thank you to Geoffrey McLennan and members of the McLennan Lab. My first job in science was as a McLennan Lab undergraduate research assistant, iii and that is where I developed many of the technical skills that I am using today on a regular basis. McLennan Lab members I worked with include:

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Section: Human Lung Developmental Biologymentioning

confidence: 99%

Quantitative morphologic assessment of the newborn cystic fibrosis pig tracheal lobe

Adam¹

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Biomimetics of fetal alveolar flow phenomena using microfluidics

et al. 2015

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At the onset of life in utero, the respiratory system begins as a liquid-filled tubular organ and undergoes significant morphological changes during fetal development towards establishing a respiratory organ optimized for gas exchange. As airspace morphology evolves, respiratory alveolar flows have been hypothesized to exhibit evolving flow patterns. In the present study, we have investigated flow topologies during increasing phases of embryonic life within an anatomically inspired microfluidic device, reproducing real-scale features of fetal airways representative of three distinct phases of in utero gestation. Micro-particle image velocimetry measurements, supported by computational fluid dynamics simulations, reveal distinct respiratory alveolar flow patterns throughout different stages of fetal life. While attached, streamlined flows characterize the shallow structures of premature alveoli indicative of the onset of saccular stage, separated recirculating vortex flows become the signature of developed and extruded alveoli characteristic of the advanced stages of fetal development. To further mimic physiological aspects of the cellular environment of developing airways, our biomimetic devices integrate an alveolar epithelium using the A549 cell line, recreating a confluent monolayer that produces pulmonary surfactant. Overall, our in vitro biomimetic fetal airways model delivers a robust and reliable platform combining key features of alveolar morphology, flow patterns, and physiological aspects of fetal lungs developing in utero.

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Fetal Breathing Movements

Cited by 2 publications

References 20 publications

Quantitative morphologic assessment of the newborn cystic fibrosis pig tracheal lobe

Quantitative morphologic assessment of the newborn cystic fibrosis pig tracheal lobe

Biomimetics of fetal alveolar flow phenomena using microfluidics

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