Fetal Cardiac Function and Ventricular Volumes Determined by Three-Dimensional Ultrasound Using STIC and VOCAL Methods in Fetuses from Pre-gestational Diabetic Women

Bravo-Valenzuela, Nathalie Jeanne; Peixoto, Alberto Borges; Mattar, Rosiane; Júnior, José Francisco Melo; Pares, David Baptista da Silva; Júnior, Edward Araujo

doi:10.1007/s00246-020-02362-7

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…However, significant differences in fetal left atrial volumes between the two groups were observed. This could be related to left atrial dysfunction, reflecting an earlier stage of cardiac dysfunction (left heart diastolic dysfunction) [28]. Alternatively, in this study, the LV and RV CO were lower in fetuses of those in the pregestational DM group than in the fetuses of those in the control group.…”

Section: Discussionmentioning

confidence: 49%

Fetal cardiac function by mitral and tricuspid annular plane systolic excursion using spatio-temporal image correlation M‐mode and left cardiac output in fetuses of pregestational diabetic mothers

et al. 2021

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ObjectiveTo assess the mitral and tricuspid annular plane systolic excursions (MAPSE and TAPSE, respectively) and cardiac output (CO) in fetuses of pregnant women with pregestational diabetes mellitus (DM) using spatio-temporal image correlation M-mode (STIC-M) and virtual organ computer-aided analysis (VOCAL). MethodsThis study was prospective and cross-sectional. It included 45 fetuses each from mothers with pregestational DM and healthy mothers, with gestation ages ranging from 20 to 36.6 weeks. The fetal cardiac volumes were obtained and analyzed by STIC and VOCAL methods. MAPSE and TAPSE were measured by STIC-M in the apical or basal fourchamber view. The values of the right (RV) and left ventricular (LV) CO were calculated by STIC and VOCAL. ResultsThe median values of TAPSE were 6.1 and 6.2 mm in the diabetic and control groups (P<0.001), respectively. The median values of MAPSE were 4.6 mm in the fetuses of mothers with diabetes and 4.8 mm in fetuses of healthy mothers. The fetal LV CO (60.4 L/min vs. 71.1 L/min; P=0.033, respectively) and RV CO (65.2 vs. 70.1 L/min; P=0.026, respectively) were lower in the pregestational DM group than in the control group. A significant effect of pregestational DM was observed in all functional parameters after adjusting, with fetal heart rate as covariant. There was moderate significant positive correlation between MAPSE and LV CO (r=0.53; P=0.0001) and between TAPSE and RV CO (r=0.46; P=0.0001). ConclusionSignificant difference in functional parameters (TAPSE, MAPSE and LV CO) obtained by STIC and VOCAL were observed in the fetuses of the pregestational DM group compared to those of the control group.

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Section: Discussionmentioning

confidence: 49%

Fetal cardiac function by mitral and tricuspid annular plane systolic excursion using spatio-temporal image correlation M‐mode and left cardiac output in fetuses of pregestational diabetic mothers

et al. 2021

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“…In this scenario, several studies have been published including ultrasound/echocardiographic fetal cardiac functional parameters by M-mode, Doppler, 2D and 3D ultrasound in the fetuses of mothers with DM. 4) 16) 17) 18) 19) Recently, a metanalysis reviewed 39 studies on fetal IVS thickness and Doppler cardiac functional parameters focusing on analyzing the effects of DM on the fetal heart. In regard to the 2D ultrasound and Doppler cardiac function parameters in this review, the E/A ratio was decreased in the DM group.…”

Section: Discussionmentioning

confidence: 99%

Fetal Interventricular Septum Volume Evaluated by Three-Dimensional Ultrasound Using Spatiotemporal Image Correlation and Virtual Organ Computer-Aided Analysis in Fetuses From Pre-Gestational Diabetes Mellitus Pregnant Women

Bravo-Valenzuela

Peixoto

Mattar

et al. 2022

J Cardiovasc Imaging

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BACKGROUND To assess the interventricular septum (IVS) volume of fetuses from pre-gestational diabetes mellitus (DM) pregnant women by 3-dimensional ultrasound using spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL) methods. METHODS This was a prospective cross-sectional study of 45 fetuses from pre-gestational DM and 45 fetuses from healthy pregnant women (controls). Only singleton pregnancies between 20 and 34 + 6 weeks of gestation were included. The fetal IVS volumes were obtained off-line using STIC and VOCAL methods. To analyze differences among variables, the Student’s t-test and Mann-Whitney U test were used. The correlation among continuous variables was determine using Spearman’s correlation test (r). RESULTS The median of fetal IVS volume was significantly higher in pre-gestational DM than in healthy pregnant women (0.3 cm 3 vs. 0.2 cm 3 , p = 0.032). A strong positive correlation was observed between fetal IVS volume and gestational age at the time of ultrasound examination (r = 0.75, R 2 = 0.48, p < 0.0001) and between fetal IVS volume and estimated fetal weight (r = 0.63, R 2 = 0.37, p < 0.0001). No significant correlation was noted between fetal IVS volume and glycated hemoglobin levels (r = −0.16, R 2 = 0.01, p = 0.540) in the pre-gestational DM pregnant women. CONCLUSIONS Significant differences were observed in fetal IVS volumes between pre-gestational and healthy mothers, with higher values in the fetuses of pre-gestational DM pregnant women.

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“…Volume measurement using 4DUS allows for virtual organ computer‐aided analysis (VOCAL) to estimate the ventricular volume and calculate the total systolic volume, ejection fraction, and cardiac output 93,94 ; SonoAVC 95 or M‐STIC can be used to calculate the AV valve annular plane systolic excursion (mitral/tricuspid annular plane systolic excursion MAPSE/TAPSE) 96 . These imaging modalities are applicable for different (patho)physiological fetal conditions (eg, normal fetuses, fetuses with cardiac anomalies, growth restricted fetuses, or diabetic pregnancies) 97‐100 . However, as aforementioned, the continuing challenge is primarily the capability of morphologic assessment rather than the description of functional and quantitative changes in cases suspicious for congenital heart disease.…”

Section: Discussionmentioning

confidence: 99%

“…96 These imaging modalities are applicable for different (patho)physiological fetal conditions (eg, normal fetuses, fetuses with cardiac anomalies, growth restricted fetuses, or diabetic pregnancies). [97][98][99][100] However, as aforementioned, the continuing challenge is primarily the capability of morphologic assessment rather than the description of functional and quantitative changes in cases suspicious for congenital heart disease.…”

Section: Discussionmentioning

confidence: 99%

A “holistic” sonographic view on congenital heart disease: How automatic reconstruction using fetal intelligent navigation echocardiography eases unveiling of abnormal cardiac anatomy part II—Left heart anomalies

Weichert

2021

Echocardiography

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Volume ultrasound has been shown to provide valid complementary information on fetal anatomy. Four‐dimensional assessment (4D) of the fetal cardiovascular system using spatial–temporal image correlation (STIC) allows for detailed examination of a highly complex organ from the early second trimester onward. There is compelling evidence that this technique harbors quite a number of diagnostic opportunities, but manual navigation through STIC volume datasets is highly operator dependent. In fact, STIC is not incorporated yet into daily practice. Application of the novel fetal intelligent navigation echocardiography (FINE) considerably simplifies fetal cardiac volumetric examinations. This automatic technique applied on cardiac volume datasets reportedly has both high sensitivity and specificity for the detection of congenital heart defects (CHDs). Part I reviewed current data regarding detection rates of CHDs and illustrated the additional value of an automatic approach in delineating cardiac anatomy exemplified by congenital lesions of the right heart. In part II of this pictorial essay, we focused on left heart anomalies and aimed to tabulate recent findings on the quantification of normal and abnormal cardiac anatomy.

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Fetal Cardiac Function and Ventricular Volumes Determined by Three-Dimensional Ultrasound Using STIC and VOCAL Methods in Fetuses from Pre-gestational Diabetic Women

Cited by 11 publications

References 32 publications

Fetal cardiac function by mitral and tricuspid annular plane systolic excursion using spatio-temporal image correlation M‐mode and left cardiac output in fetuses of pregestational diabetic mothers

Fetal cardiac function by mitral and tricuspid annular plane systolic excursion using spatio-temporal image correlation M‐mode and left cardiac output in fetuses of pregestational diabetic mothers

Fetal Interventricular Septum Volume Evaluated by Three-Dimensional Ultrasound Using Spatiotemporal Image Correlation and Virtual Organ Computer-Aided Analysis in Fetuses From Pre-Gestational Diabetes Mellitus Pregnant Women

A “holistic” sonographic view on congenital heart disease: How automatic reconstruction using fetal intelligent navigation echocardiography eases unveiling of abnormal cardiac anatomy part II—Left heart anomalies

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