Fetal Genotype for Specific Inherited Thrombophilias Is Not Associated With Severe Preeclampsia

Stanley-Christian, Heather; Ghidini, Alessandro; Sacher, Ronald A.; Shemirani, Manijeh

doi:10.1016/j.jsgi.2004.11.001

Cited by 17 publications

(8 citation statements)

References 17 publications

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“…Several studies have addressed the role of fetal inherited thrombophilias in pre‐eclampsia, only three of them have included a small number of HELLP pregnancies (Table V) (19), (23), (28), (33–38). On the whole, there was no evidence for a strong association.…”

Section: Discussionmentioning

confidence: 99%

Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women

Muetze

Leeners

Ortlepp

et al. 2008

Acta Obstet Gynecol Scand

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Objective. There is growing evidence that hypertensive pregnancy complications and other adverse pregnancy outcomes are associated with the presence of inherited or acquired thrombophilias. As hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G >A mutation and the methylenetetrahydrofolate reductase (MTHFR) 677C >T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. Design. The study was performed retrospectively in a case-control design. Sample. Seventy-one mother-child pairs with HELLP syndrome and 79 control mother-child pairs with uncomplicated pregnancies were included in the study. Methods. Genotyping of the three thrombophilic mutations was performed using the LightCycler technology. The chi-squared test was used for statistical analysis. Main outcome measures were maternal and fetal genotypes and their correlation with clinical parameters. Results. Maternal heterozygosity for factor V Leiden was significantly more prevalent in the HELLP group than in controls (OR 4.45,. No significant association was observed for maternal prothrombin mutation or MTHFR polymorphism (p=0.894, p=0.189, respectively). The fetal genotype was not associated with HELLP syndrome for any of the three mutations investigated. Analysis of gene-gene interactions and genotype-phenotype correlation with respect to clinical parameters and perinatal outcome revealed no further differences. Conclusions. Our study confirms that women heterozygous for factor V Leiden have an increased risk of developing HELLP syndrome, while the most frequent mutations of the prothrombin and MTHFR gene do not play a major role in the pathogenesis of HELLP syndrome. AbstractObjective: There is growing evidence that hypertensive pregnancy complications and other adverse pregnancy outcomes are associated with the presence of inherited or acquired thrombophilias. As HELLP syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G>A mutation and the MTHFR 677C>T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. Design:The study was performed retrospectively in a cas-control design.

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Section: Discussionmentioning

confidence: 99%

Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women

Muetze

Leeners

Ortlepp

et al. 2008

Acta Obstet Gynecol Scand

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“…However, there are also a number of similar studies that have failed to establish a close relationship between thrombophilia and poor pregnancy outcomes 14–17 …”

Section: Introductionmentioning

confidence: 99%

Thrombophilia investigation in Malaysian women with recurrent pregnancy loss

Ayadurai¹,

Muniandy²,

Omar

2009

J of Obstet and Gynaecol

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Thrombophilia was identified in more than one-quarter (26.6% = 107/402) of the RPL subjects. APC-R not caused by FVL mutation was the most common thrombophilia marker in Malaysians, whereas in Caucasians it was the APC-R due to FVL mutation. The identification of FVL and PTG mutations in Malaysian women with RPL disputes prevailing evidences suggesting its non-occurrence in patients with Asian ancestries.

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“…Several studies have addressed the role of fetal inherited thrombophilias in pre-eclampsia, only three of them have included a small number of HELLP pregnancies (Table 5) (19,23,28,(33)(34)(35)(36)(37)(38). On the whole, there was no evidence for a strong association.…”

Section: Discussionmentioning

confidence: 99%

Maternal Factor V Leiden Mutation Is Associated With HELLP Syndrome in Caucasian Women

Muetze

Leeners

Ortlepp

et al. 2008

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

Objective. There is growing evidence that hypertensive pregnancy complications and other adverse pregnancy outcomes are associated with the presence of inherited or acquired thrombophilias. As hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G >A mutation and the methylenetetrahydrofolate reductase (MTHFR) 677C >T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. Design. The study was performed retrospectively in a case-control design. Sample. Seventy-one mother-child pairs with HELLP syndrome and 79 control mother-child pairs with uncomplicated pregnancies were included in the study. Methods. Genotyping of the three thrombophilic mutations was performed using the LightCycler technology. The chi-squared test was used for statistical analysis. Main outcome measures were maternal and fetal genotypes and their correlation with clinical parameters. Results. Maternal heterozygosity for factor V Leiden was significantly more prevalent in the HELLP group than in controls (OR 4.45, 95% CI 1.31-15.31). No significant association was observed for maternal prothrombin mutation or MTHFR polymorphism (p=0.894, p=0.189, respectively). The fetal genotype was not associated with HELLP syndrome for any of the three mutations investigated. Analysis of gene-gene interactions and genotype-phenotype correlation with respect to clinical parameters and perinatal outcome revealed no further differences. Conclusions. Our study confirms that women heterozygous for factor V Leiden have an increased risk of developing HELLP syndrome, while the most frequent mutations of the prothrombin and MTHFR gene do not play a major role in the pathogenesis of HELLP syndrome. AbstractObjective: There is growing evidence that hypertensive pregnancy complications and other adverse pregnancy outcomes are associated with the presence of inherited or acquired thrombophilias. As HELLP syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G>A mutation and the MTHFR 677C>T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. Design:The study was performed retrospectively in a cas-control design. Sample: 71 motherchild pairs with HELLP syndrome and 79 control mother-child pairs with uncomplicated pregnancies were included in the study. Methods: Genotyping of the three thrombophilic mutations was performed using the LightCycler technology. The chi-squared test was used for statistical analysis.

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Fetal Genotype for Specific Inherited Thrombophilias Is Not Associated With Severe Preeclampsia

Abstract: In our study, fetal genotype for specific inherited thrombophilias does not appear to be associated with severe preeclampsia.

Cited by 17 publications

References 17 publications

Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women

Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women

Thrombophilia investigation in Malaysian women with recurrent pregnancy loss

Maternal Factor V Leiden Mutation Is Associated With HELLP Syndrome in Caucasian Women

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