Fetal nasal bone and trisomy 21 in the second trimester

Viora, E.; Errante, G.; Sciarrone, Andrea; Bastonero, S.; Masturzo, Bianca; Martiny, G; Campogrande, M

doi:10.1002/pd.848

Cited by 30 publications

(31 citation statements)

References 26 publications

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“…[16,17]. Neuere Studien bestätigen diese Ergebnisse (18,19,20). Daraus würde so gesehen ein deutlicher Nutzen für die Schwangere entstehen, da dadurch die Rate an invasiver Diagnostik und damit auch die Abortrate sinken könnte.…”

Section: Diskussionunclassified

Referenzwerte für das fetale Nasenbein im ersten Trimenon in einem Normalkollektiv

Staboulidou¹,

Steinborn²,

Schmidt³

et al. 2006

Z Geburtshilfe Neonatol

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The reference ranges for the measurement of the fetal nasal bone length are similar to the findings in the published literature. Only with a knowledge of reference ranges for nasal bone length in normal fetuses can conclusions be drawn about the presence/absence of the bone or the presence of a hypoplastic nasal bone. Further studies are necessary to confirm these results and to obtain larger datasets to assess nasal bone as a quantitative marker.

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Section: Diskussionunclassified

Referenzwerte für das fetale Nasenbein im ersten Trimenon in einem Normalkollektiv

Staboulidou¹,

Steinborn²,

Schmidt³

et al. 2006

Z Geburtshilfe Neonatol

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“…The studies essentially used one of three methods to define NB hypoplasia: (1) a measurement below the 5th percentile of the normal range for gestation [19] ; (2) a measurement below a fixed cutoff of 2.5 mm [10,22,27] or 3 mm [11] ; (3) a ratio above specific cutoffs in the ratio of the biparietal diameter to NBL [7,24,26,[28][29][30] and below 0.75 multiples of the median [8] .…”

Section: Discussionmentioning

confidence: 99%

Normal Range of Fetal Nasal Bone Length during the Second Trimester in an Afro-Caribbean Population and Likelihood Ratio for Trisomy 21 of Absent or Hypoplastic Nasal Bone

Gautier

Gueneret²,

Plavonil³

et al. 2016

Fetal Diagn Ther

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Objective: To establish the normal reference range of fetal nasal bone length (NBL) during the second trimester in an Afro-Caribbean population and the likelihood ratio (LR) for fetal trisomy 21. Methods: Prenatal records of euploid, non-malformed singleton fetuses who underwent second-trimester ultrasonographic scans at 20-24 weeks of gestation were retrospectively analyzed for NBL and gestational age (GA). Only Afro-Caribbean couples were selected. The relationship between fetal NBL and GA was determined. The data of all fetuses with Down syndrome were provided by the French West Indies Register of Congenital Malformations (REMALAN). Results: There was a significant linear association between fetal NBL and GA (R² = 0. 354). The 50th percentile for NBL increased from 5.0 to 7.0 mm from week 20 to 24 of gestation. The nasal bone (NB) was absent or hypoplastic in 8.6% of the euploid fetuses and in 69.2% of the trisomy 21 fetuses. The LR for trisomy 21 of absent or hypoplastic NB in an Afro-Caribbean population was 8.02, but only 2.32 when this sign was isolated. Conclusion: The reference range for fetal NBL at 20-24 weeks of gestation in an Afro-Caribbean population and the LR for trisomy 21 of absent or hypoplastic NB differed from the other populations.

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“…The literatures reveal that about 20% die by the age of five years due to cardiac problems [1][2][3][4][5][6][7][8][9][10]. Several sonographic features have been used for screening of DS pregnancy, and based on the observations the nasal bone features in second trimester fetal images has been considered to be an important marker [11,12]. The significance of the nasal bone length in relation to DS in the second trimester has increased the likelihood of the detection rate.…”

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confidence: 99%

Clinical decision support system for early prediction of Down syndrome fetus using sonogram images

Nirmala¹,

Palanisamy

2010

SIViP

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In this paper, the segmentation and extraction of features from ultrasound second trimester fetal images have been presented for early detection of Down syndrome. The region of interest and the edges of the segmented region have been obtained using mean shift analysis and Canny operator, respectively. The prime features such as the nasal bone, the palate and the frontal bone have been segmented for estimating the nasal bone length and frontomaxillary facial angle (FMF). It is observed from the results that the rate of growth of nasal bone length is poor and the FMF angle has been found to increase above 85 • for fetus with trisomy 21. This analysis may help the physician for better clinical diagnosis.

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Fetal nasal bone and trisomy 21 in the second trimester

Cited by 30 publications

References 26 publications

Referenzwerte für das fetale Nasenbein im ersten Trimenon in einem Normalkollektiv

Referenzwerte für das fetale Nasenbein im ersten Trimenon in einem Normalkollektiv

Normal Range of Fetal Nasal Bone Length during the Second Trimester in an Afro-Caribbean Population and Likelihood Ratio for Trisomy 21 of Absent or Hypoplastic Nasal Bone

Clinical decision support system for early prediction of Down syndrome fetus using sonogram images

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