Fetal Transfusion in Severe Rh Isoimmunization

Bowman, John M.; Friesen, Rhinehart F.; Bowman, William D.; Barnes, Philip H.; Grewar, David

doi:10.1097/00006254-196907000-00005

Cited by 7 publications

(4 citation statements)

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“…In an initially published series the overall survival rates were 24-56% [68,73,76,77]. In recently published studies an increase in perinatal survival up to 92% has been reported [56,57,69,70,72,78], Mortality rates in hydrop ic infants range between 25 and 66% [43,57,72,73], The incidence of traumatic death as the major source of mor tality, has decreased since the use of real time ultrasound guidance.…”

Section: Resultsmentioning

confidence: 99%

Management of Serious Alloimmunization in Pregnancy

Gravenhorst¹

1988

Vox Sanguinis

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In the past 40 years, tremendous advances in the treatment of hemolytic disease have been made. The perinatal mortality has been reduced considerably. Rh immunoprophylaxis has decreased the incidence of Rh immunization to around 6 per 100,000 live births. Nevertheless, treatment of severe hemolytic disease is still essential. Increased reliability of diagnostic procedures have made early detection and optimal treatment of hemolytic disease possible. Treatment by plasmapheresis is still controversial. Although believed to be beneficial by some authors, conclusive evidence of its efficacy has not been obtained. With preterm induction of birth at 32 weeks of gestation, the chances for survival are 95%. Improvement of techniques and the use of modern real-time ultrasound equipment have made intrauterine intraperitoneal transfusion, in experienced hands, a relatively safe and successful procedure. Intravascular transfusion appears beneficial in early pregnancy. Combination of both techniques will probably be the answer for the future. The development of neonatal intensive care facilities has made a major contribution to the survival of children with haemolytic disease. The relative low incidence of haemolytic disease has made it imperative that treatment should take place in centers where experience and special skill are available.

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Section: Resultsmentioning

confidence: 99%

Management of Serious Alloimmunization in Pregnancy

Gravenhorst¹

1988

Vox Sanguinis

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“…From many reports (7,11) it is obvious that the results are better in the last half of the investigational period and several point out that the accumulating experience of a small team brings improving results. Bowman et al (7) improved the survival rate from 28 % in the first part of the transfusion period to 62% in the last part. Our results confirm this tendency with a survival rate of 72% in the last 3 years of the investigational period.…”

Section: Table VIII the Survival Rates At Different Centres With Recmentioning

confidence: 99%

“…The advisability of performing an intra-uterine transfusion when the fetus appears to be hydropic has been questioned (2, 12, 18). Some authors (7,14), however, report survival rates among hydropic fetuses (prenatal radiological diagnosis) of up to 30 %. However, the diagnosis of fetal hydrops in early gestation is difficult (13) and has to be related to other criteria for selection.…”

Section: Table VIII the Survival Rates At Different Centres With Recmentioning

confidence: 99%

Intra‐Uterine Transfusion in the Management of Pregnant Women with Severe Rhesus Isoimmunization

Bock

1976

Acta Obstet Gynecol Scand

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Abstruct. The results of 51 intra-uterine transfusions in 34 pregnant women with severe rhesus isoimmunization are presented. The survival rate is 56%. Factors influencing the fetal and neonatal mortality are considered, e.g. the gestational age at the initial intra-uterine transfusion, the presence of fetal hydrops, and the interval from the initial intra-uterine transfusion to delivery. The difficulties of the selection procedure are emphasized and it is stated that in some cases intra-uterine transfusion should perhaps not be performed because of a predictable poor fetal prognosis. The significance of accumulating experience is discussed.

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“…Εκείνο πού δέν ξέρουμε είναι αν και πόσα άπό τά ενεργοποιημένα λεμφοκύτταρα είναι λεμφοκύτταρα του δότη. 'Αφού όμως αντίδραση «μο σχεύματος και ξενιστή» πάρα πολύ σπάνια δημιουργείται ύστερα άπό εν δομήτρια μετάγγιση 18 ή εξωμήτρια ΑΦΜ και άφοΰ το έμβρυο έχει κιόλας αποκτήσει τήν ικανότητα νά απορρίπτει τά ξένα κύτταρα τη 16η εβδομάδα της ζωής του 73 είναι λογικόν νά συμπεράνουμε πώς είναι τοΰ νεογνού τά ενεργοποιημένα κύτταρα πού αντιδρούν.…”

Section: μεθοδος *-unclassified

Η Ανταποκριση Στη Φυτοαιμοσυγκολλητικη (Pha) Των Νεογνικων Λεμφοκυτταρων Μετα Απο Μεταγγιση Και Αφαιμαξομεταγγιση

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Fetal Transfusion in Severe Rh Isoimmunization

Cited by 7 publications

References 0 publications

Management of Serious Alloimmunization in Pregnancy

Management of Serious Alloimmunization in Pregnancy

Intra‐Uterine Transfusion in the Management of Pregnant Women with Severe Rhesus Isoimmunization

Η Ανταποκριση Στη Φυτοαιμοσυγκολλητικη (Pha) Των Νεογνικων Λεμφοκυτταρων Μετα Απο Μεταγγιση Και Αφαιμαξομεταγγιση

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