Fetal Umbilical Arterial Pulsatility Correlates With 2-Year Growth and Neurodevelopmental Outcomes in Congenital Heart Disease

Abeysekera, Jayani; Gyenes, Dora; Atallah, Joseph; Robertson, Charlene M.T.; Bond, Gwen Y.; Rebeyka, Ivan M.; Moez, Elham Khodayari; Dinu, Irina; Switzer, Heather; Hornberger, Lisa K.

doi:10.1016/j.cjca.2020.06.024

Cited by 13 publications

(25 citation statements)

References 48 publications

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“…41,43,46,54 Four studies exclusively examined TGA [55][56][57][58][59] and 5 studies examined SVP and TGA simultaneously. 37,39,[60][61][62] TOF was exclusively examined in 1 study, 63 and 1 study examined both TOF and TGA. 64 Interrupted aortic arch (IAA) was exclusively examined in 1 study.…”

Section: Resultsmentioning

confidence: 99%

“…64 Interrupted aortic arch (IAA) was exclusively examined in 1 study. 65 Twelve studies assessed motor development between 0 and 12 months, 38,40,41,44,45,47,50,52,55,56,61,63 12 studies between 12 and 24 months, 37,39,40,46,48,53,[58][59][60]62,64,65 5 studies between 24 and 36 months, 42,49,51,54,61 and 2 studies above 36 months. 43,60 None of the included studies examined motor development in children 4.5 years and older.…”

Section: Resultsmentioning

confidence: 99%

“…40,45,50 Nineteen mean results (38.8%) reported in 14 studies indicated a below average (between −2 and −1 SD) motor development, 38,39,41,44,47,48,[51][52][53]55,60,61,64,65 and 24 mean outcomes (49.0%) reported in 20 different studies indicated an average motor development. 37,39,[41][42][43]46,[49][50][51][54][55][56][57][58][59][60][61][62][63][64] Single-Ventricle Physiology. Twenty-two studies included children with SVP with a total of 34 different mean motor developmental outcomes.…”

Section: Results Of Individual Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Motor Developmental Delay After Cardiac Surgery in Children With a Critical Congenital Heart Defect: A Systematic Literature Review and Meta-analysis

Sprong

Broeders

Net

et al. 2021

Pediatric Physical Therapy

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Purpose: To systematically review evidence regarding the severity and prevalence of motor development in children with a critical congenital heart defect (CCHD) without underlying genetic anomalies. Summary of Key Points: Twelve percent of all included studies reported abnormal mean motor developmental scores, and 38% reported below average motor scores. Children with single-ventricle physiology, especially those with hypoplastic left heart syndrome, had the highest severity and prevalence of motor delay, particularly at 0 to 12 months. Most included studies did not differentiate between gross and fine motor development, yet gross motor development was more affected. Recommendations for Clinical Practice: We recommend clinicians differentiate between the type of heart defect, fine and gross motor development, and the presence of genetic anomalies. Furthermore, increased knowledge about severity and prevalence will enable clinicians to tailor their interventions to prevent motor development delays in CCHD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Results Of Individual Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Motor Developmental Delay After Cardiac Surgery in Children With a Critical Congenital Heart Defect: A Systematic Literature Review and Meta-analysis

Sprong

Broeders

Net

et al. 2021

Pediatric Physical Therapy

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“…Placental insufficiency, likely related to increased placental resistance, has been associated with worse growth measures and neurodevelopment outcomes at age 2 years. 9 Both prenatal and postnatal interventions could be of benefit. Maternal health interventions before delivery could optimize the fetal environment to maximize fetal growth.…”

Section: Garick D Hill Md Msmentioning

confidence: 99%

Commentary: The growing problem in congenital heart surgery

Hill

2021

The Journal of Thoracic and Cardiovascular Surgery

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“…Fetal hemodynamic disturbances and cardiac dysfunction may result in Doppler alterations ( 10 , 11 ). Fetal Doppler is the most common and direct method to evaluate fetal safety in utero .…”

Section: Introductionmentioning

confidence: 99%

Alterations in Fetal Doppler Parameters Before and Twenty-Four Hours After Radiofrequency Ablation for Twin Reversed Arterial Perfusion Sequence

et al. 2022

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ObjectiveTo evaluate alterations in the fetal Doppler parameters of pump fetuses before and 24 h after radiofrequency ablation surgery for twin reversed arterial perfusion sequence (TRAPs).MethodsThis is a retrospective study of 28 pump fetuses in TRAPs and 28 normal control twins between 2016 and 2021. The fetal Doppler parameters, including the umbilical artery pulsatility index (UA-PI), middle cerebral artery peak systolic velocity (MCA-PSV), middle cerebral artery pulsatility index (MCA-PI), and cerebroplacental ratio (CPR), of the controls, and pump fetuses before and 24 h after surgery were compared.ResultsAn increasing trend and a further increase in the MCA-PSV, MCA-PI, MCA-PSV Z score, and MCA-PI Z score after surgery were observed in pump fetuses with gestational age (GA) ≥20 weeks; however, such changes were not observed in those with a GA of <20 weeks. The UA-PI and CPR before and after surgery were not different between control and pump fetuses, whether the GA was ≥20 or <20 weeks.ConclusionIn the middle second trimester, the pump fetus might suffer from high cardiac output rather than hypoxemia before surgery and congestive heart failure, or hemodilutional anemia after surgery. This may provide some theoretical evidence in favor of early intervention, rather than waiting for a more advanced GA, to avoid unnecessary hemodynamic alterations.

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Fetal Umbilical Arterial Pulsatility Correlates With 2-Year Growth and Neurodevelopmental Outcomes in Congenital Heart Disease

Cited by 13 publications

References 48 publications

Motor Developmental Delay After Cardiac Surgery in Children With a Critical Congenital Heart Defect: A Systematic Literature Review and Meta-analysis

Motor Developmental Delay After Cardiac Surgery in Children With a Critical Congenital Heart Defect: A Systematic Literature Review and Meta-analysis

Commentary: The growing problem in congenital heart surgery

Alterations in Fetal Doppler Parameters Before and Twenty-Four Hours After Radiofrequency Ablation for Twin Reversed Arterial Perfusion Sequence

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