Feto-maternal Bone Remodeling in Normal Pregnancy and Preeclampsia

Abstract

Increased bone resorption and decreased bone formation occur in preeclampsia in both mother and fetus, being more pronounced in the latter. The increased osteoclastic activity in preeclampsia may be attributed to increased RANKL induced by increased interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor beta2 (TGF-beta2) production.

Circulating Osteoprotegerin and sRANKL Concentrations in the Perinatal Period at Term

“…The increased osteoclastic activity in preeclamptic women may possibly be attributed to an increase in RANKL (which, however, was not measured [24] ). Nevertheless, our study, comprising not only preeclamptic but also women with pregnancy-induced hypertension, did not demonstrate any differences in serum OPG and sRANKL concentrations between the study groups.…”

“…On the other hand, in pregnancies complicated with preeclampsia, increased bone resorption has been reported in both mothers and fetuses [24,25] . The increased osteoclastic activity in preeclamptic women may possibly be attributed to an increase in RANKL (which, however, was not measured [24] ).…”

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

“…In addition, maternal plasma IL-6 levels are elevated in women with PE [71,72], and increasing IL-6 levels can stimulate production of agonistic auto-antibodies to the angiotensin II type 1 receptor. The source of increasing IL-6 in maternal plasma remains unknown [73,74], but several studies found that the placenta is not the source.…”

Expression of Concern: Bone turnover in preeclampsia‐complicated pregnancy in North Indian women

“…The urinary DPD and serum osteocalcin levels were higher in preeclampsia than in normotensive pregnancy 36 . The OC and PICP levels were significantly decreased in severe preeclampsia, whereas the NTx level was significantly increased compared to the corresponding levels of controls 37 . The ICTP and PICP levels were significantly increased in women with preeclampsia compared with the normal pregnant controls 7 …”