Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Dabrowska, Anna; Tarach, Jerzy S.; Wojtysiak-Duma, Beata; Duma, D

doi:10.5507/bp.2015.018

Cited by 87 publications

(103 citation statements)

References 60 publications

(215 reference statements)

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“…Circulating fetuin‐A levels increase with increasing body mass index. As a tyrosine kinase inhibitor, fetuin‐A is linked to insulin resistance and diabetes mellitus but it is also an inhibitor of calcification by building complexes with calcium and phosphorus 52, 53. Circulating fetuin‐A concentrations were not associated with any of the echocardiographic traits we evaluated in our sample.…”

Section: Discussionmentioning

confidence: 76%

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Jeinsen

Short

Xanthakis

et al. 2018

JAHA

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BackgroundAdipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity‐associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community‐based sample.Methods and ResultsWe evaluated 3514 Framingham Heart Study participants (mean age 40 years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid–binding protein 4, retinol‐binding protein 4, fetuin‐A, and adiponectin. We used multivariable linear regression, adjusting for known correlates (including weight), to relate adipokine concentrations (independent variables) to the following echocardiographic measures (dependent variables): left ventricular mass index, left atrial diameter in end systole, fractional shortening, and E/e′. In multivariable‐adjusted analysis, left ventricular mass index was inversely related to circulating leptin and fatty acid–binding protein 4 concentrations but positively related to retinol‐binding protein 4 and leptin receptor levels (P≤0.002 for all). Left atrial end‐systolic dimension was inversely related to leptin but positively related to retinol‐binding protein 4 concentrations (P≤0.0001). E/e′ was inversely related to leptin receptor levels (P=0.0002). We observed effect modification by body weight for select associations (leptin receptor and fatty acid–binding protein 4 with left ventricular mass index, and leptin with left atrial diameter in end systole; P<0.05 for interactions). Fractional shortening was not associated with any of the adipokines. No echocardiographic trait was associated with fetuin‐A or adiponectin concentrations.ConclusionsIn our cross‐sectional study of a large, young to middle‐aged, relatively healthy community‐based sample, key indices of subclinical cardiac remodeling were associated with higher or lower circulating concentrations of prohypertrophic and antihypertrophic adipokines in a context‐specific manner. These observations may offer insights into the pathogenesis of the cardiomyopathy of obesity.

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Section: Discussionmentioning

confidence: 76%

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Jeinsen

Short

Xanthakis

et al. 2018

JAHA

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“…soluble, adsorbed, exchangeable, precipitated, complexed [5]. The most frequently used method of heavy metals fractionation -Tessier method -distinguish five fractions of heavy metals: exchangeable, carbonate bound, iron oxides bound, organic and residual [5]. Information on the extractability and fractionation of heavy metals in sewage sludge, especially the sludge chemically stabilized are insufficient.…”

Section: Introductionmentioning

confidence: 99%

“…Heavy metals occur in sewage sludge and soil in various forms, e.g. soluble, adsorbed, exchangeable, precipitated, complexed [5]. The most frequently used method of heavy metals fractionation -Tessier method -distinguish five fractions of heavy metals: exchangeable, carbonate bound, iron oxides bound, organic and residual [5].…”

Section: Introductionmentioning

confidence: 99%

“…-1 [3]. The content of this metal in sewage sludge rarely is higher than set by law standards [5,6], however it is more bioavailable for plants and even at allowable concentrations can be toxic for plants and living organisms. Ni is mainly bound by Fe oxides [3].…”

Section: Introductionmentioning

confidence: 99%

“…It is mainly present in the sludge in the residual fraction and adsorbed by Fe oxides and organic matter [3]. Thus it is not susceptible for release [5]. Intake of Pb in soil and sludge is also affected by carbonates.…”

Section: Introductionmentioning

confidence: 99%

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Selected heavy metals speciation in chemically stabilised sewage sludge

Wiśniowska

Włodarczyk‐Makuła

2017

E3S Web Conf.

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Abstract. Selected heavy metals (Pb, Ni, Cd) were analysed in soil, digested sewage sludge as well as in the sludge stabilised with CaO or Fenton's reagent. The dose of Fenton's reagent was as follows: Fe 2+ = 1g . L -1 , Fe 2+ /H2O2=1:100; stabilisation lasted for 2 h. Dose of CaO was equal to 1 g CaO . g d.m. -1 Total concentration of all metals in the digested sewage sludge was higher than in the soil. Chemical stabilisation of sludge with Fenton's reagent increased total metal content in the sludge as a result of total solids removal. Opposite effect was stated when the sludge was mixed with CaO. Also chemical fractions of heavy metals were identified (exchangeable, carbonate bound, iron oxides bound, organic and residual). The results indicate that stabilisation of the sludge with Fenton's reagent increased mobility of heavy metals compared to the digested sludge. Amendment of CaO increased percent share of examined metals in residual fraction, thus immobilised them and decreased their bioavailability.

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Metabo groups in response to micronutrient intervention: Pilot study

Coelho-Landell

Salomão

Almada

et al. 2019

Food Science & Nutrition

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Micronutrients and their metabolites are cofactors in proteins involved in lipid metabolism. The present study was a subproject of the Harmonized Micronutrient Project (ClinTrials.gov # NCT01823744). Twenty participants were randomly selected from 136 children and adolescents that consumed a daily dose of 12 vitamins and 5 minerals supplementation for 6 weeks. The 20 individuals were divided into two pools of 10 individuals, according to their lipid profile at baseline (Pool 1 with lower triglycerides, LDL, and VLDL). The individuals were analyzed at baseline, after 6 weeks of daily supplementation, and after 6 weeks of a washout period in relation to anthropometric, body composition, food intake, lipid profile, micronutrient levels, and iTRAQ proteomic data. Genetic ancestry and its association with vitamin serum levels were also determined. After supplementation, LDL levels decreased while alpha-tocopherol and pantothenic acid levels increased in pool 2; lipid profiles in pool 1 did not change but had higher plasma levels of pantothenic acid, pyridoxal, and pyridoxic acid. In pool 2, expression of some proteins increased, and expression of other ones decreased after intervention, while in pool 1, the same proteins responded inversely or did not change their levels. Plasma alpha-tocopherol and Native American genetic ancestry explained a significant fraction of LDL plasma levels at baseline and in response to the intervention. After intervention, changes in expression of alpha-1 antitrypsin, haptoglobin, Ig alpha-1 chain C region, plasma protease C1 inhibitor, alpha-1-acid glycoprotein 1, fibrinogen alpha, beta, and gamma-chain in individuals in pool 2 may be associated with levels of LDL and vitamin E. Vitamin E and Native American genetic ancestry may also be implicated in changes of vitamin E and LDL levels. The results of this pilot study must be validated in future studies with larger sample size or in in vitro studies. 20 participants were divided into two metabolic groups according only to their lipid profiles: individuals in pool 1 (n = 10) had lower triglycerides, LDL, and VLDL levels, and individuals in pool 2 K E Y W O R D S genetic ancestry, intervention study, lipid profile, metabolomics, proteomics, Vitamin plasma levels

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Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Cited by 87 publications

References 60 publications

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Selected heavy metals speciation in chemically stabilised sewage sludge

Metabo groups in response to micronutrient intervention: Pilot study

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