Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly

Abstract

Background: Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin. Methods: In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices. Results: Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P < 0.05). Logistic regression analysis indicated that F/A ratio presented a stronger correlation with incident MS (adjusted OR: 1.466; 95% CI: 1.189-1.808) than fetuin-A (adjusted OR: 1.100; 95% CI: 1.020-1.186) and adiponectin (adjusted OR: 0.760; 95% CI: 0.664-0.871) alone. ROC analysis revealed that F/A ratio achieved a larger area under curve (AUC) than fetuin-A and adiponectin, with their AUC values of 0.755, 0.709 and 0.708, respectively. Conclusion: F/A ratio is a more sensitive index for evaluating MS than either fetuin-A or adiponectin in the elderly.

Clinical Significance of the Fetuin-A-to-Adiponectin Ratio in Obese Children and Adolescents with Diabetes Mellitus

“…Our findings suggest that FAR could provide a more precise interpretation than each component and could be a more sensitive surrogate for future metabolic disorders in diabetic children, particularly those who are obese. The results of the present study are consistent with those of previous studies [ 16 , 24 ].…”

“…As both fetuin-A and adiponectin are linked to the mechanism underlying obesity but function in an opposite direction, the fetuin-A values adjusted by adiponectin seem to exhibit a higher performance. Zhou et al showed the causal relationship between fetuin-A and various metabolic parameters associated with MetS, which was not highlighted in our study population [ 24 ]. Nonetheless, the following findings were consistent with the results of previous studies [ 24 ]: FAR in diabetic children (i) was the highest in the entire population, (ii) had a stronger correlation with BMI, and (iii) acted as a MetS indicator compared to controls.…”

Fetuin-A and Fetuin-B in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression

“…In addition, current evidence in genetics suggests that, compared with the healthy controls, patients with liver steatosis have higher expression of fetuin-A mRNA in hepatocytes and serum fetuin-A concentrations [5]. The different amounts of this protein in the two groups could be due to the fact that fetuin-A (a2HS-glycoprotein), which is a glycoprotein produced by the adipose tissue and liver, has a dual function, that is, it restrains the insulin receptor and brings about insulin resistance in the pancreas, skeletal muscle, and hepatocytes [6]. It also has an inverse relationship with tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) level, which is the critical factor in systemic inflammation in NAFLD [7].…”

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

“…(9,10) A somewhat older parameter, fetuin A, has recently been suggested for the evaluation of some obesity-related diseases. (11,12) Spexin (SPX) is also called neuropeptide Q (NPQ). It is a novel biologically active neuropeptidewidely expressed in central nervous system and peripheral tissues.…”

“…It is also reported as an indicator for evaluating MetS and the severity of coronary artery disease.There are opposing findings related to functions of fetuin A. (11,12,(24)(25)(26) The aim of this study is to determine profiles of some new generation cytokines to make some possible contribution to studies performed in the field of obesity. For the purpose, serum levels of spexin, adipolin, adropin, FGF-21 and fetuin A were measured and their relations with anthropometric measurements as well as with eachother were investigated in children with normal BMI, obesity, morbid obesity and MetS.…”