Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis

El-Dakroury, Walaa A.; Zewail, Moataz B.; Asaad, Gihan F.; Abdallah, Heba M.I.; Shabana, Marwa E.; Said, Abdelrahman R.; Doghish, Ahmed S.; Azab, Hadeer A.; Amer, Dalia H.; Hassan, Ahmed E.; Sayed, Alaa S.; Samra, Ghada M.; Sallam, Al-Aliaa M.

doi:10.1016/j.ejpb.2024.114205

European Journal of Pharmaceutics and Biopharmaceutics

2024

DOI: 10.1016/j.ejpb.2024.114205

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Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis

Walaa A. El-Dakroury,

Moataz B. Zewail,

Gihan F. Asaad

et al.

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2024

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Cited by 6 publications

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Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Liu,

Huang,

et al. 2024

ChemistrySelect

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Ulcerative colitis (UC) is a chronic non‐specific inflammatory disease of the intestines with a high prevalence. Polymer‐prepared nanoparticles are well‐targeted, highly biocompatible, and have high potential for personalized therapy. Polymer nanoparticles are able to achieve localized therapy through their unique design. First, this review compares the advantages and disadvantages of natural and synthetic polymeric materials as well as describes the application of polymeric nanoparticles in UC therapy. Then, the preparation, characterization methods, and current challenges of common polymer nanoparticles are presented. Next, one‐by‐one examples of polymer nanoparticle‐targeted drug delivery strategies for the treatment of UC are presented. In addition, polymer nanoparticle‐based therapeutic approaches for UC, including anti‐inflammatory therapies, reactive oxygen species scavenging therapies, and intestinal flora modulation therapies, are presented. Finally, future research directions for polymer nanoparticles in UC therapy are discussed and current challenges are identified. The aim of this paper is to provide valuable references and guidance for researchers to design and develop novel UC therapies.

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Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Liu,

Huang,

et al. 2024

ChemistrySelect

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Bioinspired and bioderived nanomedicine for inflammatory bowel disease

Gazzi,

Gelli,

Aleandri

et al. 2024

WIREs Nanomed Nanobiotechnol

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Due to its chronic nature and complex pathophysiology, inflammatory bowel disease (IBD) poses significant challenges for treatment. The long‐term therapies for patients, often diagnosed between the ages of 20 and 40, call for innovative strategies to target inflammation, minimize systemic drug exposure, and improve patients' therapeutic outcomes. Among the plethora of strategies currently pursued, bioinspired and bioderived nano‐based formulations have garnered interest for their safety and versatility in the management of IBD. Bioinspired nanomedicine can host and deliver not only small drug molecules but also biotherapeutics, be made gastroresistant and mucoadhesive or mucopenetrating and, for these reasons, are largely investigated for oral administration, while surprisingly less for rectal delivery, recommended first‐line treatment approach for several IBD patients. The use of bioderived nanocarriers, mostly extracellular vesicles (EVs), endowed with unique homing abilities, is still in its infancy with respect to the arsenal of nanomedicine under investigation for IBD treatment. An emerging source of EVs suited for oral administration is ingesta, that is, plants or milk, thanks to their remarkable ability to resist the harsh environment of the upper gastrointestinal tract. Inspired by the unparalleled properties of natural biomaterials, sophisticated avenues for enhancing therapeutic efficacy and advancing precision medicine approaches in IBD care are taking shape, although bottlenecks arising either from the complexity of the nanomedicine designed or from the lack of a clear regulatory pathway still hinder a smooth and efficient translation to the clinics.This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies

Yang,

Zhu,

Wei

et al. 2024

Biomater. Sci.

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Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis

Cited by 6 publications

References 84 publications

Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Bioinspired and bioderived nanomedicine for inflammatory bowel disease

Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies

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