FGF-10 Is a Chemotactic Factor for Distal Epithelial Buds during Lung Development

Park, William Y.; Miranda, B.; Lebeche, Djamel; Hashimoto, Gakuji; Cardoso, Wellington V.

doi:10.1006/dbio.1998.8994

Cited by 295 publications

(261 citation statements)

References 26 publications

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“…(84)(85)(86) In this view, GDNF performs a chemoattractive role in the kidney analogous to that proposed for FGF10 in lung epithelia branching. (54,87) This idea is supported by a number of observations, such as the ability of GNDF beads to apparently attract the growth of ectopic UBs from the Wolffian duct; (21,30,52) the migration of cultured Ret-expressing cells towards a source of GDNF, (78) a role of GDNF in pathfinding by the pronephric duct of the axolotl (88) and as a chemoattractant for migrating enteric neural crest cells. (89,90) As discussed above, it is clear that the expression domain of GDNF provides positional information that helps to determine the site of outgrowth of the primary UB from the WD.…”

Section: The Role Of Localized Gdnf/ret Signaling In Ureter Formationmentioning

confidence: 92%

GDNF/Ret signaling and the development of the kidney

2006

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SummarySignaling by GDNF through the Ret receptor is required for normal growth of the ureteric bud during kidney development. However, the precise role of GDNF/Ret signaling in renal branching morphogenesis and the specific responses of ureteric bud cells to GDNF remain unclear. Recent studies have provided new insight into these issues. The localized expression of GDNF by the metanephric mesenchyme, together with several types of negative regulation, is important to elicit and correctly position the initial budding event from the Wolffian duct. GDNF also promotes the continued branching of the ureteric bud. However, it does not provide the positional information required to specify the pattern of ureteric bud growth and branching, as its site of synthesis can be drastically altered with minimal effects on kidney development. Cells that lack Ret are unable to contribute to the tip of the ureteric bud, apparently because GDNF-driven proliferation is required for the formation and growth of this specialized epithelial domain.

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Section: The Role Of Localized Gdnf/ret Signaling In Ureter Formationmentioning

confidence: 92%

GDNF/Ret signaling and the development of the kidney

2006

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“…In vitro FGF10 is both a chemoattractant and a mitogen for the lung epithelium during branching (Bellusci et al, 1997b;Park et al, 1998). Fgf10 hypomorphs have decreased levels of epithelial proliferation during the pseudoglandular stage and this is associated with decreased levels of distal epithelial phosphorylated-ERK MAPK and decreased expression of a canonical Wnt pathway reporter (Ramasamy et al, 2007).…”

Section: Epithelial Progenitor Regulationmentioning

confidence: 99%

The building blocks of mammalian lung development

Rawlins

2010

Developmental Dynamics

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Progress has recently been made in identifying progenitor cell populations in the embryonic lung. Some progenitor cell types have been definitively identified by lineage-tracing studies. However, others are not as well characterized and their existence is inferred on the basis of lung morphology, or mutant phenotypes. Here, I focus on lung development after the specification of the initial lung primordium. The evidence for various lung embryonic progenitor cell types is discussed and future experiments are suggested. The regulation of progenitor proliferation in the embryonic lung, and its coordinate control with morphogenesis, is also discussed. In addition, the relationship between embryonic and adult lung progenitors is considered. Developmental Dynamics 240:463-476,

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“…Although Fgf does affect cell proliferation at the bud tips, it has been argued, based on studies of lung bud explants, that these local changes in proliferation are not the triggering event that initiates lung budding, indirectly implying that the control of cell migration is a possible major player in branching (Nogawa et al, 1998). Indeed, Fgf can control cell migration in cultured mouse lung cells (Park et al, 1998). In the developing air sac in Drosophila, a branched organ that also grows tremendously during the branching process due to cell division, two different receptor tyrosine kinases, Egfr and Fgfr, have been linked to the control of cell proliferation and cell migration, respectively (Cabernard and Affolter, 2005) (see Fig.…”

Section: Do General Cellular Principles Underlie Branching Morphogenementioning

confidence: 99%

Tracheal branching morphogenesis inDrosophila: new insights into cell behaviour and organ architecture

2008

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2055Our understanding of the molecular control of morphological processes has increased tremendously over recent years through the development and use of high resolution in vivo imaging approaches, which have enabled cell behaviour to be linked to molecular functions. Here we review how such approaches have furthered our understanding of tracheal branching morphogenesis in Drosophila, during which the control of cell invagination, migration, competition and rearrangement is accompanied by the sequential secretion and resorption of proteins into the apical luminal space, a vital step in the elaboration of the trachea's complex tubular network. We also discuss the similarities and differences between flies and vertebrates in branched organ formation that are becoming apparent from these studies. IntroductionBranching morphogenesis restructures epithelial sheets to give rise to organs of fascinating three-dimensional architecture, as exemplified by the adult lung, the kidney and the vasculature in humans. In Drosophila melanogaster, genetic studies have provided much insight into the regulatory networks that regulate the ordered formation of tracheal branches in the embryo, and into how the different branches coordinate their relative sizes, an issue that is of importance to the physical aspects of branched organ function (Affolter et al., 2003;Ghabrial et al., 2003;Uv et al., 2003). More recently, the development of live-imaging approaches in Drosophila have allowed researchers to take a deeper look at the behaviour of cells during the branching process, and have enabled events at the molecular level to be linked to the behaviour of individual cells or groups of cells.This combination of molecular genetics and live-imaging techniques has provided investigators with a unique opportunity to understand the morphological processes that occur during branching morphogenesis. This review focuses and builds on some of these recent insights, and assesses how they have led to a better understanding of the cellular and molecular processes that contribute to the transformation of simple, two-dimensional epithelial sheets into fascinating, three-dimensional tubular structures that can perform important functions in development and homeostasis. We focus here on the Drosophila tracheal system because several cellular and molecular paradigms, such as cell migration, competition and rearrangement, as well as the elaboration of a complex apical luminal environment, have recently been uncovered in this system that might serve related roles in the formation of other branched organs or tissues; these similarities might help us in the future to gain an even better understanding of how morphogenesis in general is regulated during development. Tracheal development in the fly embryoThe complex structure of the tracheal system consists of interconnected, metameric units of different-sized tubes that extend over the entire embryo shortly before hatching (Samakovlis et al., 1996b) (see Fig. 1, see also Movie 1 in the supplementary material)....

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FGF-10 Is a Chemotactic Factor for Distal Epithelial Buds during Lung Development

Cited by 295 publications

References 26 publications

GDNF/Ret signaling and the development of the kidney

GDNF/Ret signaling and the development of the kidney

The building blocks of mammalian lung development

Tracheal branching morphogenesis inDrosophila: new insights into cell behaviour and organ architecture

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