FGF–FGFR signaling promotes the development of invasive cervical cancer

Mateus, Duarte; Wiedlocha, Antoni G

doi:10.1111/febs.16384

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…An in vitro study conducted on human cervical cancer cell lines, HeLa, SiHa, and CaSki, further confirmed the role of the bFGF/FGFR pathway, in which increased bFGF was reported [ 207 ].…”

Section: Bfgf and Cancermentioning

confidence: 61%

Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value

Ardizzone

Bova

Casili

et al. 2023

Cells

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Cancer is the leading cause of death worldwide; thus, it is necessary to find successful strategies. Several growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF, FGF2), and transforming growth factor beta (TGF-β), are involved in the main processes that fuel tumor growth, i.e., cell proliferation, angiogenesis, and metastasis, by activating important signaling pathways, including PLC-γ/PI3/Ca2+ signaling, leading to PKC activation. Here, we focused on bFGF, which, when secreted by tumor cells, mediates several signal transductions and plays an influential role in tumor cells and in the development of chemoresistance. The biological mechanism of bFGF is shown by its interaction with its four receptor subtypes: fibroblast growth factor receptor (FGFR) 1, FGFR2, FGFR3, and FGFR4. The bFGF–FGFR interaction stimulates tumor cell proliferation and invasion, resulting in an upregulation of pro-inflammatory and anti-apoptotic tumor cell proteins. Considering the involvement of the bFGF/FGFR axis in oncogenesis, preclinical and clinical studies have been conducted to develop new therapeutic strategies, alone and/or in combination, aimed at intervening on the bFGF/FGFR axis. Therefore, this review aimed to comprehensively examine the biological mechanisms underlying bFGF in the tumor microenvironment, the different anticancer therapies currently available that target the FGFRs, and the prognostic value of bFGF.

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“…An in vitro study conducted on human cervical cancer cell lines, HeLa, SiHa, and CaSki, further confirmed the role of the bFGF/FGFR pathway, in which increased bFGF was reported [ 207 ].…”

Section: Bfgf and Cancermentioning

confidence: 61%

Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value

Ardizzone

Bova

Casili

et al. 2023

Cells

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show abstract

“…Analysis of upregulated DEGs induced by rPACAP showed that fibroblast growth factor 17 (FGF17) expression was significantly upregulated in the treatment group (log2 fold‐change = 2.89, p = 0.0019, Figure 5E). The FGF/FGFR signalling network plays a critical role in the development of invasive cervical cancer 34 . Therefore, FGF17 might play a critical role in PNI of cervical cancer.…”

Section: Resultsmentioning

confidence: 99%

“…The FGF/FGFR signalling network plays a critical role in the development of invasive cervical cancer. 34 Therefore, FGF17 might play a critical role in PNI of cervical cancer. Apart from chemoattractants secreted by SCs induce PNI, it is also plausible that SCs facilitate cancer cell dissemination along nerves by an additional mechanism.…”

Section: Resultsmentioning

confidence: 99%

Dedifferentiated Schwann cells promote perineural invasion mediated by the PACAP paracrine signalling in cervical cancer

Chen,

Zheng,

Sun

et al. 2023

J Cellular Molecular Medi

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Perineural invasion (PNI) has emerged as a key pathological feature and be considered as a poor prognostic factor in cervical cancer. However, the underlying molecular mechanisms are largely unknown. Here, PNI status of 269 cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) samples were quantified by using whole‐slide diagnostic images obtained from The Cancer Genome Atlas. Integrated analyses revealed that PNI was an indicative marker of poorer disease‐free survival for CESC patients. Among the differentially expressed genes, ADCYAP1 were identified. Clinical specimens supported that high expression of PACAP (encoded by ADCYAP1) contributed to PNI in CESC. Mechanistically, PACAP, secreted from cervical cancer cells, reversed myelin differentiation of Schwann cells (SCs). Then, dedifferentiated SCs promoted PNI by producing chemokine FGF17 and by degrading extracellular matrix through secretion of Cathepsin S and MMP‐12. In conclusion, this study identified PACAP was associated with PNI in cervical cancer and suggested that tumour‐derived PACAP reversed myelin differentiation of SCs to aid PNI.

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“…Interestingly, they also show that FGFR signaling regulates human papillomavirus (HPV)‐dependent gene expression, suggesting a critical role for this signaling axis in cervical cancer. A Commentary from Duarte Mateus and Antoni Wiedlocha highlights the impact of these findings on FGFR signaling in the study of invasive cervical cancer [7].…”

Section: Developmental Signaling Pathways In Disease Mechanismsmentioning

confidence: 99%

Role of developmental pathways in disease

Derry

2023

The FEBS Journal

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Developmental programs are tightly regulated networks of molecular and cellular signaling pathways that orchestrate the formation and organization of tissues and organs during organismal development. However, these programs can be disrupted or activated in an untimely manner, or in the wrong tissues, and this can lead to a host of diseases. This aberrant reactivation can occur due to a multitude of factors, including genetic mutations, environmental influences, or epigenetic modifications. Consequently, cells may undergo abnormal growth, differentiation, or migration, leading to structural abnormalities or functional impairments at the tissue or organismal level. This Subject Collection of The FEBS Journal on Developmental Pathways in Disease highlights 11 reviews and three research articles that cover a broad array of topics focused on the role of signaling pathways critical for normal development that are deregulated in human disease.

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FGF–FGFR signaling promotes the development of invasive cervical cancer

Cited by 4 publications

References 13 publications

Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value

Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value

Dedifferentiated Schwann cells promote perineural invasion mediated by the PACAP paracrine signalling in cervical cancer

Role of developmental pathways in disease

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