FGF10 is differentially expressed in high-grade serous ovarian cancers.

Mamoor, Shahan

doi:10.31219/osf.io/ba2jg

Cited by 1 publication

(1 citation statement)

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“…FGF10 is expressed at all stages of follicle development and its mRNA and proteins are localized in theca interna cells and granulosa cells ( 23 , 24 ). Abnormal FGF10 expression is often closely related to tumor occurrence, and the expression of FGF10 in high-grade ovarian tumors is significantly different from that in normal tissues ( 25 ). Furthermore, FGF10 up-regulation can be used as a biomarker to predict the survival of patients with ovarian epithelial cancer ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated transcriptomic and metabolomic investigation of the genes and metabolites involved in swine follicular cyst formation

Dai,

Pang,

Cai

et al. 2024

Front. Vet. Sci.

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Follicular cysts are a common reproductive disorder in mammals that is usually caused by stress. However, the pathogenesis of follicular cysts in sows remains unclear. To provide new insights into the mechanisms of follicular cyst formation in pigs, we conducted a combined transcriptomic and metabolomic analysis on theca interna and mural granulosa cells of follicular cysts and mature follicles. We identified 2,533 up-regulated and 1,355 down-regulated genes in follicular cysts, compared with mature follicles. These differentially expressed genes were mainly found in signaling pathways related to tumor formation and cortisol synthesis and secretion as shown by Ingenuity Pathway Analysis, which predicted 4,362 upstream regulatory factors. The combined gene expression and pathway analysis identified the following genes as potential biomarkers for porcine follicular cysts: cytochrome P450 family 2 subfamily C polypeptide 18, L-lactate dehydrogenase, carbamoyl-phosphate synthase, fibroblast growth factor 7, integrin binding sialoprotein, interleukin 23 receptor, prolactin receptor, epiregulin, interleukin 1 receptor type II, arginine vasopressin receptor 1A, fibroblast growth factor 10, claudin 7, G Protein Subunit Gamma 3, cholecystokinin B receptor and cytosolic phospholipase A2. Metabolomics analysis found significant differences in 87 metabolites, which were enriched in unsaturated fatty acid biosynthesis, and sphingolipid signaling pathways. These results provide valuable information on the molecular mechanisms of follicular cyst formation, which may facilitate the development of new therapeutics to prevent and treat follicular cysts.

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