FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats

Gulfo, José; Rotondo, Floriana; León, Cindy G. Avalos de; Cornide‐Petronio, María Eugenia; Fuster, Carla; Gracia‐Sancho, Jordi; Jiménez‐Castro, Mónica B.; Peralta, Carmen

doi:10.1016/j.jhep.2020.05.007

Cited by 15 publications

(18 citation statements)

References 39 publications

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“…Moreover, an involvement of IQGAP1 in YAP1-driven oncogenesis was proposed in liver cancer [21]. This work showed that IQGAP1 effects on YAP1-signalling were shown to be mediated by bile acids, which are arising as important regulators of Hippo signally downstream of FGFR4 [22][23][24] Here we identify IQGAP1 as a new regulator of the core kinases of the MST2 pathway and confirm that it regulates YAP1 signalling. In particular, we characterise the molecular mechanistic effect of IQGAP1 in the Hippo pathway and show that this protein prevents the activation of the proapoptotic signal mediated by the pathway.…”

Section: Introductionsupporting

confidence: 57%

IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

Quinn¹,

García-Gutiérrez²,

Doherty³

et al. 2021

Preprint

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The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results indicate that IQGAP1 scaffolds MST2 and LATS1, supresses their kinase activity, and YAP1-dependent transcription. Additionally, we show that IQGAP1 is a negative regulator of the non-canonical pro-apoptotic pathway and may enable the crosstalk between this pathway and the ERK and AKT signalling modules. Our data also show that bile acids regulate the IQGAP1-MST2-LATS1 signalling module in hepatocellular carcinoma cells which could be necessary for the inhibition of MST2-dependent apoptosis and hepatocyte transformation.

show abstract

Section: Introductionsupporting

confidence: 57%

IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

Quinn¹,

García-Gutiérrez²,

Doherty³

et al. 2021

Preprint

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show abstract

“…It is well known that, under brain death conditions, the gut and hepatic blood flow is reduced and this makes drug delivery to the appropriate site of action and at the optimal concentration difficult. In addition, a recent study by our group of steatotic and non-steatotic LT from brain-dead donors indicates the critical role of the gut–liver axis and the relevance of FGF15/19 in the pathogenesis of hepatic I/R injury and regenerative failure [ 73 ].…”

Section: Pharmacological Strategies To Regulate Adiponectin Actionmentioning

confidence: 99%

Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?

Heydari

Cornide‐Petronio

Jiménez‐Castro

et al. 2020

IJMS

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The review describes the role of adiponectin in liver diseases in the presence and absence of surgery reported in the literature in the last ten years. The most updated therapeutic strategies based on the regulation of adiponectin including pharmacological and surgical interventions and adiponectin knockout rodents, as well as some of the scientific controversies in this field, are described. Whether adiponectin could be a potential therapeutic target for the treatment of liver diseases and patients submitted to hepatic resection or liver transplantation are discussed. Furthermore, preclinical and clinical data on the mechanism of action of adiponectin in different liver diseases (nonalcoholic fatty disease, alcoholic liver disease, nonalcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma) in the absence or presence of surgery are evaluated in order to establish potential targets that might be useful for the treatment of liver disease as well as in the practice of liver surgery associated with the hepatic resections of tumors and liver transplantation.

show abstract

Section: Introductionmentioning

confidence: 99%

IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

Quinn

García-Gutiérrez

Doherty

et al. 2021

Cells

View full text Add to dashboard Cite

The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results indicate that IQGAP1 scaffolds MST2 and LATS1 supresses their kinase activity and YAP1-dependent transcription. Additionally, we show that IQGAP1 is a negative regulator of the non-canonical pro-apoptotic pathway and may enable the crosstalk between this pathway and the ERK and AKT signalling modules. Our data also show that bile acids regulate the IQGAP1-MST2-LATS1 signalling module in hepatocellular carcinoma cells, which could be necessary for the inhibition of MST2-dependent apoptosis and hepatocyte transformation.

show abstract

FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats

Cited by 15 publications

References 39 publications

IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?

IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

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