FGFR3 Down-Regulation is Involved in bacillus Calmette-Guérin Induced Bladder Tumor Growth Inhibition

Langle, Yanina; Belgorosky, Denise; McCormick, Bárbara Prack; Sahores, Ana; Góngora, Adrián; Baldi, Alberto; Lanari, Claudia; Lamb, Caroline A.; Eiján, Ana María

doi:10.1016/j.juro.2015.06.093

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…We investigated the response to BCG therapy. Expression of FGFR3 has been found a BCG response marker, which corroborates the data in mice from Langle et al 21 . Indeed, in the Langle et al study, the responder group showed low expression of FGFR3, which we also found.…”

Section: Discussionsupporting

confidence: 89%

Assessment of prognostic implication of a panel of oncogenes in bladder cancer and identification of a 3-gene signature associated with recurrence and progression risk in non-muscle-invasive bladder cancer

Goux

Vacher

Schnitzler

et al. 2020

Sci Rep

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This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prognostic markers. Mutations of HRAS, FGFR3, PIK3CA and TERT were found in 2.9%, 27.2%, 14.9% and 76.7% of tumor samples, respectively. Concerning NMIBC, on multivariate analysis, RXRA and FGFR3 levels were associated with recurrence-free survival (RFS) (p = 0.0022 and p = 0.0069) and RXRA level was associated with progression to muscle-invasive disease (p = 0.0068). We identified a 3-gene molecular signature associated with NMIBC prognosis. FGFR3 overexpression was associated with reduced response to Bacillus Calmette–Guerin treatment (p = 0.037). As regards MIBC, on multivariate analysis, ERCC2 overexpression was associated with RFS (p = 0.0011) and E2F3 and EGFR overexpression were associated with overall survival (p = 0.014 and p = 0.035). RT-PCR findings were confirmed by IHC for FGFR3. Genomic alterations in MIBC revealed in TCGA data also concern NMIBC and seem to be associated with prognosis in terms of recurrence and progression. Correcting these alterations by targeted therapies seems a promising pharmacological approach.

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Section: Discussionsupporting

confidence: 89%

Assessment of prognostic implication of a panel of oncogenes in bladder cancer and identification of a 3-gene signature associated with recurrence and progression risk in non-muscle-invasive bladder cancer

Goux

Vacher

Schnitzler

et al. 2020

Sci Rep

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“…We also found that FGFR3, a member of the bladder cancer signaling pathway, was significantly downregulated, indicating an aggressive characteristic and a worse prognosis. In the aspect of FGFR3 expression, those expression levels in the EP subtype were significantly higher than in the others across NMIBC patient cohorts (Supplementary Figure S2), supporting a poor responsiveness to BCG treatment in the EP subtype and consistent with the previous investigation [18]. The alteration in expression levels of genes involved in REC.BCG+-associated pathways was validated in the UROMOL cohort 5A).…”

Section: Biologic Characteristics Of the Molecular Subtypes Of Nmibcsupporting

confidence: 82%

A molecular signature determines the prognostic and therapeutic subtype of non-muscle-invasive bladder cancer responsive to intravesical Bacillus Calmette-Guérin therapy

Yun¹,

Kang²,

Kim³

et al. 2021

European Urology

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“…42 FGFR3 is a receptor tyrosine kinase that is involved in cell functions such as proliferation, differentiation, and development of tumor cells. 43 These results suggest that BAPN-1 may potentially affect targets that are essential for cancer survival. Additionally, we observed that the upregulated genes upon BAPN-1 treatment were mainly related to inflammatory and immunomodulatory responses.…”

Section: Homogeneity and Chemical Analysis Of Bapn-1mentioning

confidence: 94%

Exploring the Health Benefits of Boletus aereus Polysaccharides: Extraction, Structural Characterization, and Antiproliferative Properties against Non-Hodgkin’s Lymphomas (NHLs)

Wang,

Yang,

Qiu

et al. 2024

J. Agric. Food Chem.

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Boletus aereus Fr. ex Bull. stands out as a delectable edible mushroom with high nutritional and medicinal values, featuring polysaccharides as its primary nutrient composition. In our continuous exploration of its beneficial substances, a novel polysaccharide (BAPN-1) with a molecular weight of 2279 kDa was prepared. It was identified as a glucan with a backbone composed of the residues →4)-α-Glcp-(1→ and →4,6)-α-Glcp-(1→ connected in a proportion of 5:1 and a β-Glcp-(1→ side residue attached at C6 of the →4,6)-α-Glcp-(1→ residue. Biologically, BAPN-1 exhibited broad-spectrum antiproliferative activities against various NHL cells,

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FGFR3 Down-Regulation is Involved in bacillus Calmette-Guérin Induced Bladder Tumor Growth Inhibition

Cited by 14 publications

References 24 publications

Assessment of prognostic implication of a panel of oncogenes in bladder cancer and identification of a 3-gene signature associated with recurrence and progression risk in non-muscle-invasive bladder cancer

Assessment of prognostic implication of a panel of oncogenes in bladder cancer and identification of a 3-gene signature associated with recurrence and progression risk in non-muscle-invasive bladder cancer

A molecular signature determines the prognostic and therapeutic subtype of non-muscle-invasive bladder cancer responsive to intravesical Bacillus Calmette-Guérin therapy

Exploring the Health Benefits of Boletus aereus Polysaccharides: Extraction, Structural Characterization, and Antiproliferative Properties against Non-Hodgkin’s Lymphomas (NHLs)

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