Fiber-cap biosensors for SERS analysis of liquid samples

Credi, Caterina; Bibikova, Olga; Dallari, Caterina; Tiribilli, Bruno; Ratto, Fulvio; Centi, Sonia; Pini, Roberto; Artyushenko, Viacheslav; Cicchi, Riccardo; Pavone, Francesco S.

doi:10.1039/c9tb01866b

Cited by 25 publications

(22 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the three types of NPs used, AuNSts modified-PDMS caps obtained the highest values of AEF due to the shape of these nanostructures increases the possibility of "hot spots" formation. Functionalization of the NPs with a specific antibody for the Aβ 1-42 monomer (anti-Aβ) allowed SERS detection of Aβ at the µM level, obtaining an increase of 100-fold in Raman signals in the NPs-decorated caps, with similar behavior for AuNRs and AuNSts, respectively [63]. These results show that metal nanostructures are useful for the detection of target analytes and generate a SERS-enhancement effect.…”

Section: Sers Biosensors For Aβ Detectionmentioning

confidence: 64%

“…On the other hand, the concept of SERS-on-fiber technology for diagnostic purposes has been recently developed by the same research group [63]. The integration of a cap SERS-active substrate composed of AuNSps, AuNSts, and CTAB-capped gold nanorods (AuNRs) is assembled in PDMS on the tip of an optical fiber, as shown in Figure 4B.…”

Section: Sers Biosensors For Aβ Detectionmentioning

confidence: 99%

See 1 more Smart Citation

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Oyarzún

Tapia-Arellano

Cabrera

et al. 2021

Sensors

View full text Add to dashboard Cite

Alzheimer’s disease (AD), considered a common type of dementia, is mainly characterized by a progressive loss of memory and cognitive functions. Although its cause is multifactorial, it has been associated with the accumulation of toxic aggregates of the amyloid-β peptide (Aβ) and neurofibrillary tangles (NFTs) of tau protein. At present, the development of highly sensitive, high cost-effective, and non-invasive diagnostic tools for AD remains a challenge. In the last decades, nanomaterials have emerged as an interesting and useful tool in nanomedicine for diagnostics and therapy. In particular, plasmonic nanoparticles are well-known to display unique optical properties derived from their localized surface plasmon resonance (LSPR), allowing their use as transducers in various sensing configurations and enhancing detection sensitivity. Herein, this review focuses on current advances in in vitro sensing techniques such as Surface-enhanced Raman scattering (SERS), Surface-enhanced fluorescence (SEF), colorimetric, and LSPR using plasmonic nanoparticles for improving the sensitivity in the detection of main biomarkers related to AD in body fluids. Additionally, we refer to the use of plasmonic nanoparticles for in vivo imaging studies in AD.

show abstract

Section: Sers Biosensors For Aβ Detectionmentioning

confidence: 64%

Section: Sers Biosensors For Aβ Detectionmentioning

confidence: 99%

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Oyarzún

Tapia-Arellano

Cabrera

et al. 2021

Sensors

View full text Add to dashboard Cite

show abstract

“…At the same time, the PH parameters formed in water can be optimized by changing the contrast of the refractive index of the fiber material and the medium. Moreover, the results of this work may be of interest for surface texturing [ 35–37 ] and nanostructuring, biosensing, [ 38 ] fiber‐based subwavelength optical micromanipulation, [ 39–41 ] improvement of data storage, engraving and microwelding, to name a few. These subjects will be investigated in the further works.…”

Section: Resultsmentioning

confidence: 99%

Concept of photonic hook scalpel generated by shaped fiber tip with asymmetric radiation

Minin

Liu²,

Tuchin

et al. 2020

Journal of Biophotonics

View full text Add to dashboard Cite

Structured light have made deep impacts on modern biotechnology and clinical practice, with numerous optical systems and lasers currently being used in medicine to treat disease. We demonstrate a new concept of fiber‐based optical hook scalpel. The subwavelength photonic hook is obtained in the vicinity of a shaped fiber tip with asymmetric radiation. A 1550 nm continuous‐wave source, commonly used for medical imaging, has been required. Photonic hook with a lateral feature size less than the half‐wavelength is achieved using a hemispherical shaped fiber tip with metallic mask. This breakthrough is carried out in ambient air by using a 4‐μm‐diameter fiber with a shaped tip. A good correlation is observed between the computed intensity distribution of photonic hook and the tip sizes. Photonic hook generated with a shaped fiber tip, easier to manipulate, shows far‐reaching benefits for potential applications such as ophthalmic laser surgery, super‐resolution microscopy, photolithography and material processing.

show abstract

“…In the back scattered mode, the SERS active nanostructures are fabricated on the tip of a fiber which carries the laser excitation light and collects the back scattered light [90,91]. Basically, this mode of detection has more applicability in remote sensing or in-vivo diagnostics.…”

Section: Reflection/back Scattering Modementioning

confidence: 99%

Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

2022

View full text Add to dashboard Cite

Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have seen a surge in research activities related to solving the challenges associated with precise on-site bio-sensing. Cutting-edge fiber optic technology enables the interaction of light with functionalized fiber surfaces at remote locations to develop a novel, miniaturized and cost-effective lab on fiber technology for bio-sensing applications. The recent remarkable developments in the field of nanotechnology provide innumerable functionalization methodologies to develop selective bio-recognition elements for label free biosensors. These exceptional methods may be easily integrated with fiber surfaces to provide highly selective light-matter interaction depending on various transduction mechanisms. In the present review, an overview of optical fiber-based biosensors has been provided with focus on physical principles used, along with the functionalization protocols for the detection of various biological analytes to diagnose the disease. The design and performance of these biosensors in terms of operating range, selectivity, response time and limit of detection have been discussed. In the concluding remarks, the challenges associated with these biosensors and the improvement required to develop handheld devices to enable direct target detection have been highlighted.

show abstract

Fiber-cap biosensors for SERS analysis of liquid samples

Abstract: Versatile optical sensors were engineered to reversibly transform fiber-based photonic systems into SERS substrates for molecular probing of liquid samples.

Cited by 25 publications

References 44 publications

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Concept of photonic hook scalpel generated by shaped fiber tip with asymmetric radiation

Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

Contact Info

Product

Resources

About