Fiber composition of the rat sciatic nerve

Schmalbruch, Henning

doi:10.1002/ar.1092150111

Cited by 370 publications

(256 citation statements)

References 17 publications

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“…The unmyelinated axons in rhGDNF-treated animals were larger, not smaller, than their counterparts in vehicle-treated animals. These results are comparable with those in previous studies on the fiber composition of the rat sciatic nerve (Schmalbruch, 1986).…”

Section: Myelination Of Small Axonssupporting

confidence: 92%

Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers

et al. 2003

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Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the development and maintenance of a subset of dorsal root ganglion sensory neurons. We administered high-dose exogenous recombinant human GDNF (rhGDNF) daily to adult rats to examine its effect on unmyelinated axon-Schwann cell units in intact peripheral nerves. In rhGDNF-treated animals, there was a dramatic proliferation in the Schwann cells of unmyelinated fibers, which resulted in the segregation of many unmyelinated axons into a 1:1 relationship with Schwann cells and myelination of normally unmyelinated small axons. This study demonstrates that the administration of high doses of a growth factor to adult rats can change the phenotype of nerve fibers from unmyelinated to myelinated.

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Section: Myelination Of Small Axonssupporting

confidence: 92%

Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers

et al. 2003

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“…Later, it was described that the proximal portion of this nerve is constituted by a single fascicle (Schmalbruch, 1986), as we have also shown in the present study.…”

Section: Macroscopicsupporting

confidence: 89%

Aspects of the Macro and Microscopic Anatomy of the Sciatic Nerve in Wistar Rats

Suaid

Santos

Yamane³

et al. 2016

Int. J. Morphol.

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. Aspects of the macro and microscopic anatomy of the sciatic nerve in Wistar rats. Int. J. Morphol., 34(3):877-884, 2016. SUMMARY:The present study seeks to systematize morphological and morphometrical parameters and brings new data on the main branch of the lumbosacral plexus -i.e., sciatic nerve -in Wistar rats aged four and seven weeks. Sixteen female were divided into two groups, namely animals aged four weeks, and animals aged seven weeks. The specimens were studied at proximal and distal segments of the right hind limb sciatic nerves. Semi-thin transverse sections (0.25 µm thickness) were stained with 1 % toluidine blue, and the morphometric analysis was processed through the KS 400 software. Except for the number of fascicles and fascicular diameter, no differences were found between the proximal and distal segments. We observed differences when morphometric values were compared between 4-and 7-week old animals, with some exceptions (number of fascicles and myelinated fibers, and capillary area and number). The macroscopic data disagree with a previous description of the sciatic nerve being composed by two fascicles. Instead, sciatic nerve's only fascicle trifurcates or quadrifurcates at the distal third of the thigh. The total capillary area and density were calculated, and these are the first referential data for the sciatic nerve. Histograms of myelinated fiber and axons considering the animal ages were built. The results presented here are important because experimental studies, mainly studies on nerve regenerations require comparison with normal reliable data.

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“…According to histochemical tests reactivity, the levator labii superioris muscle is consisted of a mosaic distribution different from the results found by Schmalbruch (1986), in which the values were between 0.42 mm and 7.65 mm in the tibial and femoral nerve in the rat. This observation is probably related with the frequency of the different fiber types in the levator labii superioris muscle, that has a predominance of white fibers, that is fast twitch fibers (Table IV).…”

Section: Discussioncontrasting

confidence: 72%

Morphological Study of Myoneural Interaction between the Levator Labii Superioris Muscle and its Motor Nerve in Rats

Melo¹,

Shinohara²,

Andreo³

et al. 2009

Int. J. Morphol.

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SUMMARY:The progress of science in search of new techniques of the nerve regeneration and the functional repair in reinnervated muscle has been the target of many researchers around the world. Consequently, nerves and muscles in different body segments asked for more enlightenment of their morphology, their interrelation with other anatomic structures and their peculiarities. One of the most significant areas that need deeper studies is the region of the head and neck, since they are often affected by important pathologies. In order to offer the researcher's community a morphological myoneural interaction model, this study elected the levator labii superioris muscle and its motor nerve, the buccal branch of the facial nerve (VII pair) not only for its special characteristics, but also its value on the facial expression. The rat was chosen for this investigation for being easy to obtain, to keep, to manipulate and to compare this experiment with many others studies previously published. The techniques used were Mesoscopic (dissection), histoenzymologic and morphometric ones.In the results the muscle proved to have a predominance of fast twich fibers (FG and FOG) and superficial location, with a proximal bone and a distal cutaneous insertion. Its motor nerve, the buccal branch of the facial nerve (VII pair), breaks through the muscle belly into its deep face, and comprised a heterogeneous group of myelinic nerve fibers disposed in a regular form in all fascicle. Near the motor point, the nerve showed to be composed of two fascicles with different sizes. Due to the small nerve dimensions, the nerve fibers have a smaller diameter if compared to the motor nerve of pectineus muscle of the cat. Further studies with neural tracers have already had a start in order to provide more information about the distribution and the architecture of these fibers.

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Fiber composition of the rat sciatic nerve

Cited by 370 publications

References 17 publications

Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers

Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers

Aspects of the Macro and Microscopic Anatomy of the Sciatic Nerve in Wistar Rats

Morphological Study of Myoneural Interaction between the Levator Labii Superioris Muscle and its Motor Nerve in Rats

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