Fiber-integrated WGM optofluidic chip enhanced by microwave photonic analyzer for cardiac biomarker detection with ultra-high resolution

Niu, Panpan; Jiang, Junfeng; Liu, Kun; Wang, Shuang; Jing, Jian-Ying; Xu, Tianhua; Wang, Tong; Liu, Yize; Liu, Tiegen

doi:10.1016/j.bios.2022.114238

Cited by 30 publications

(13 citation statements)

References 57 publications

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“…In addition, a comprehensive comparison between the proposed LC-sensitization and the reported cTnI immunosensors is given in Table S1 . Compared with our previous works [ 34 , 35 , 36 ], the proposed immunosensor with LC sensitization avoids additional gain configuration and complex demodulation, provides comparable LOD and resolution with ultralow consumption, making it more suitable for the microanalysis of biomarkers.…”

Section: Resultsmentioning

confidence: 98%

Prefab Hollow Glass Microsphere-Based Immunosensor with Liquid Crystal Sensitization for Acute Myocardial Infarction Biomarker Detection

et al. 2022

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Quantitative detection of cardiac troponin biomarkers in blood is an important method for clinical diagnosis of acute myocardial infarction (AMI). In this work, a whispering gallery mode (WGM) microcavity immunosensor based on a prefab hollow glass microsphere (HGMS) with liquid crystal (LC) sensitization was proposed and experimentally demonstrated for label-free cardiac troponin I-C (cTnI-C) complex detection. The proposed fiber-optic immunosensor has a simple structure; the tiny modified HGMS serves as the key sensing element and the microsample reservoir simultaneously. A sensitive LC layer with cTnI-C recognition ability was deposited on the inner wall of the HGMS microcavity. The arrangement of LC molecules is affected by the cTnI-C antigen—antibody binding in the HGMS, and the small change of the surface refractive index caused by the binding can be amplified owing to the birefringence property of LC. Using the annular waveguide of the HGMS, the WGMs were easily excited by the coupling scanning laser with a microfiber, and an all-fiber cTnI-C immunosensor can be achieved by measuring the resonant wavelength shift of the WGM spectrum. Moreover, the dynamic processes of the cTnI-C antigen—antibody binding and unbinding was revealed by monitoring the wavelength shift continuously. The proposed immunosensor with a spherical microcavity can be a cost-effective tool for AMI diagnosis.

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Section: Resultsmentioning

confidence: 98%

Prefab Hollow Glass Microsphere-Based Immunosensor with Liquid Crystal Sensitization for Acute Myocardial Infarction Biomarker Detection

et al. 2022

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“…Another recent innovation was delivered by Niu et al, where they proposed a fiber-integrated optofluidic chip enhanced by microwave photonic analyzer for cTnI-C sensing. 81 In this approach, a whispering gallery mode (WGM) fiber was integrated with an optofluidic chip to adjust the wavelength of the sensing laser produced from the sensor, whose wavelength was set to proportional to the concentration of cTnI-C (Figure 5c). The variation in cTnI-C concentration creates a slight wavelength shift in the sensing laser compared to the reference laser in the fiber.…”

Section: ■ Sensing Techniquesmentioning

confidence: 99%

“…Additionally, the mFBG system has the potential for researchers to explore how immune activity may be amplified at body temperature, further providing insight into the rapid diagnosis of heart disease. Another recent innovation was delivered by Niu et al, where they proposed a fiber-integrated optofluidic chip enhanced by microwave photonic analyzer for cTnI-C sensing . In this approach, a whispering gallery mode (WGM) fiber was integrated with an optofluidic chip to adjust the wavelength of the sensing laser produced from the sensor, whose wavelength was set to proportional to the concentration of cTnI-C (Figure c).…”

Section: Sensing Techniquesmentioning

confidence: 99%

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Recent Advances in Cardiovascular Disease Biosensors and Monitoring Technologies

et al. 2023

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Cardiovascular disease (CVD) causes significant mortality and remains the leading cause of death globally. Thus, to reduce mortality, early diagnosis by measurement of cardiac biomarkers and heartbeat signals presents fundamental importance. Traditional CVD examination requires bulky hospital instruments to conduct electrocardiography recording and immunoassay analysis, which are both time-consuming and inconvenient. Recently, development of biosensing technologies for rapid CVD marker screening attracted great attention. Thanks to the advancement in nanotechnology and bioelectronics, novel biosensor platforms are developed to achieve rapid detection, accurate quantification, and continuous monitoring throughout disease progression. A variety of sensing methodologies using chemical, electrochemical, optical, and electromechanical means are explored. This review first discusses the prevalence and common categories of CVD. Then, heartbeat signals and cardiac blood-based biomarkers that are widely employed in clinic, as well as their utilizations for disease prognosis, are summarized. Emerging CVD wearable and implantable biosensors and monitoring bioelectronics, allowing these cardiac markers to be continuously measured are introduced. Finally, comparisons of the pros and cons of these biosensing devices along with perspectives on future CVD biosensor research are presented.

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“…Table 1 summarizes a series of various biosensing technologies for cTnI that have been reported in recent years [31][32][33][34][35][36]. Compared with the existing and emerging biosensors, the packaged thin-walled microbubble biosensor has a lager measure range and lower DL of cTnI.…”

Section: Detection Of Ctnimentioning

confidence: 99%

Label‐free detection of cardiac troponin‐I with packaged thin‐walled microbubble resonators

Guo

Zhao

Zhou

et al. 2022

Journal of Biophotonics

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The measurement of cardiac troponin‐I (cTnI) is widely used for diagnosing acute myocardial infarction (AMI) diseases because of its myocardial specificity. Packaged microbubble resonators with thin wall are utilized for label‐free and specific detection of cTnI based on whispering gallery mode (WGM). This packaged structure can provide a good protection for the biosensor, improve the anti‐interference ability of the sensor and reduce the system noise. The theoretical detection limit of the biosensors for cTnI in phosphate buffer saline (PBS) is 0.4 ag mL−1 (0.02 aM). Furthermore, we demonstrated that the biosensors can be used to detect cTnI molecules in simulated serum and the theoretical detection limit is also 0.4 ag mL−1 (0.02 aM). These results are much far below the clinical cut‐off value and show a huge application potential for the detection of cardiac biomarkers of AMI.

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Fiber-integrated WGM optofluidic chip enhanced by microwave photonic analyzer for cardiac biomarker detection with ultra-high resolution

Cited by 30 publications

References 57 publications

Prefab Hollow Glass Microsphere-Based Immunosensor with Liquid Crystal Sensitization for Acute Myocardial Infarction Biomarker Detection

Prefab Hollow Glass Microsphere-Based Immunosensor with Liquid Crystal Sensitization for Acute Myocardial Infarction Biomarker Detection

Recent Advances in Cardiovascular Disease Biosensors and Monitoring Technologies

Label‐free detection of cardiac troponin‐I with packaged thin‐walled microbubble resonators

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