Fiber SPR biosensor sensitized by MOFs for MUC1 protein detection

Wang, Rui; Liu, Chunlan; Wei, Yong; Ran, Ze; Jiang, Tianci; Liu, Chunbiao; Shi, Chen; Ren, Zhuo; Wang, Xingkai; Liu, Zhihai

doi:10.1016/j.talanta.2023.124467

Cited by 17 publications

(2 citation statements)

References 33 publications

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“…Wang et al used MOF materials for surface modification of U-shaped SPR sensors to improve the sensitivity. 23 After the detection of the MUC1 protein, it was found that the sensitivity was improved by 1.62-fold and the LOD was reduced by 0.75-fold, which has a good prospect for application in the clinical detection of tumor markers (Fig. 1g).…”

Section: Introductionmentioning

confidence: 94%

Surface plasmonic biosensors: principles, designs and applications

Liu,

Fu,

Yang

et al. 2023

Analyst

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Section: Introductionmentioning

confidence: 94%

Surface plasmonic biosensors: principles, designs and applications

Liu,

Fu,

Yang

et al. 2023

Analyst

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“…In recent years, with the maturation of optical fiber manufacturing processes and a reduction of cost, a large number of optical fiber biosensors have been designed and utilized [4][5][6]. Optical fiber sensors have advantages such as their small size, light weight, and immunity to electromagnetic interference, which are extraordinarily suitable for monitoring label-free tumor biomarkers [7,8]. Wei et al designed a microfiber coupler based on serum pre-adsorption to monitor CEACAM5 in blood, with a detection limit of up to 34.6 fg/mL [9].…”

Section: Introductionmentioning

confidence: 99%

A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis

Liu,

Lin,

Zhao

et al. 2024

Biosensors

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Carcinoembryonic antigen (CEACAM5), as a broad-spectrum tumor biomarker, plays a crucial role in analyzing the therapeutic efficacy and progression of cancer. Herein, we propose a novel biosensor based on specklegrams of tapered multimode fiber (MMF) and two-dimensional convolutional neural networks (2D-CNNs) for the detection of CEACAM5. The microfiber is modified with CEA antibodies to specifically recognize antigens. The biosensor utilizes the interference effect of tapered MMF to generate highly sensitive specklegrams in response to different CEACAM5 concentrations. A zero mean normalized cross-correlation (ZNCC) function is explored to calculate the image matching degree of the specklegrams. Profiting from the extremely high detection limit of the speckle sensor, variations in the specklegrams of antibody concentrations from 1 to 1000 ng/mL are measured in the experiment. The surface sensitivity of the biosensor is 0.0012 (ng/mL)−1 within a range of 1 to 50 ng/mL. Moreover, a 2D-CNN was introduced to solve the problem of nonlinear detection surface sensitivity variation in a large dynamic range, and in the search for image features to improve evaluation accuracy, achieving more accurate CEACAM5 monitoring, with a maximum detection error of 0.358%. The proposed fiber specklegram biosensing scheme is easy to implement and has great potential in analyzing the postoperative condition of patients.

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Research on Fiber Optic Surface Plasmon Resonance Biosensors: A Review

Wang,

Zhang,

Qian

et al. 2024

Photonic Sens

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Due to the benefits of the high sensitivity, real-time response, no labeling requirement, and good selectivity, fiber optic sensors based on surface plasmon resonance (SPR) have gained popularity in biochemical sensing in recent years. The current research on such sensors is hot in enhancing sensitivity, improving detection accuracy, and achieving the detection of biochemical molecules. The goal of this work is to present a thorough overview of recent developments in the optical fiber SPR biosensor research. Firstly, it explores the basic principles and sensing structures of optical fiber SPR biosensors, focusing on four aspects. Subsequently, this paper introduces three fiber optic surface plasmon biosensors: SPR, localized surface plasmon resonance (LSPR), and long-range surface plasmon resonance (LRSPR). Each concept is explained from the perspective of the basic principles of fiber optic SPR biosensors. Furthermore, a classification of fiber optic SPR biosensors in health monitoring, food safety, environmental monitoring, marine detection, and other applications is introduced and analyzed. Eventually, this paper summarizes the current research directions of SPR biosensors. Meanwhile, it provides a prospective outlook on how fiber optic SPR sensors will develop in the future.

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Fiber SPR biosensor sensitized by MOFs for MUC1 protein detection

Cited by 17 publications

References 33 publications

Surface plasmonic biosensors: principles, designs and applications

Surface plasmonic biosensors: principles, designs and applications

A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis

Research on Fiber Optic Surface Plasmon Resonance Biosensors: A Review

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