Fibrinogen: a predictor of stroke and marker of atherosclerosis

Eidelman, Rachel S.; Hennekens, Charles H.

doi:10.1016/s0195-668x(02)00810-2

Cited by 45 publications

(33 citation statements)

References 7 publications

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“…During inflammation, overexpression of interleukin-1 and interleukin-6 leads to an increased blood content of Fg (Nakamura et al, 1996). Elevated blood level of Fg is a biomarker of inflammation and high risk factor for many cardiovascular (Danesh et al, 2005) and cerebrovascular disorders (del Zoppo et al, 2009) such as hypertension (Lominadze et al, 1998) and stroke (Eidelman and Hennekens, 2003). While normal blood concentration of Fg is about 2 mg/mL (Lominadze et al, 2010), during hypertension it reaches 4 mg/mL (Lominadze et al, 1998) and 3.6 mg/mL after ischemic stroke in humans (Eidelman and Hennekens, 2003).…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen-Induced Increased Pial Venular Permeability in Mice

Muradashvili

Qipshidze

Munjal

et al. 2011

J Cereb Blood Flow Metab

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Elevated blood level of Fibrinogen (Fg) is commonly associated with vascular dysfunction. We tested the hypothesis that at pathologically high levels, Fg increases cerebrovascular permeability by activating matrix metalloproteinases (MMPs). Fibrinogen (4 mg/mL blood concentration) or equal volume of phosphate-buffered saline (PBS) was infused into male wild-type (WT; C57BL/6J) or MMP-9 gene knockout (MMP9À/À) mice. Pial venular leakage of fluorescein isothiocyanate-bovine serum albumin to Fg or PBS alone and to topically applied histamine (10 À5 mol/L) were assessed. Intravital fluorescence microscopy and image analysis were used to assess cerebrovascular protein leakage. Pial venular macromolecular leakage increased more after Fg infusion than after infusion of PBS in both (WT and MMP9À/À) mice but was more pronounced in WT compared with MMP9À/À mice. Expression of vascular endothelial cadherin (VE-cadherin) was less and plasmalemmal vesicle-associated protein-1 (PV-1) was greater in Fg-infused than in PBS-infused both mice groups. However, in MMP9À/À mice, VE-cadherin expression was greater and PV-1 expression was less than in WT mice. These data indicate that at higher levels, Fg compromises microvascular integrity through activation of MMP-9 and downregulation of VE-cadherin and upregulation of PV-1. Our results suggest that elevated blood level of Fg could have a significant role in cerebrovascular dysfunction and remodeling.

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Section: Introductionmentioning

confidence: 99%

Fibrinogen-Induced Increased Pial Venular Permeability in Mice

Muradashvili

Qipshidze

Munjal

et al. 2011

J Cereb Blood Flow Metab

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“…However, it remains unclear whether this increased fibrinogen is a cause or as a consequence of atherosclerosis. 7,8 Diagnostic efficiency of cardiac troponin within 2 to 4 hours of onset of symptoms is limited. Therefore, a biochemical test laboratory capable of reducing emergency delays during hospital admissions for chest pain patients has the potential to significantly increase clinical and hospital income.…”

Section: Introductionmentioning

confidence: 99%

Association of Mean Platelet Volume and Fibrinogen with Major Cardiovascular Events in Acute Coronary syndrome

Andriany¹,

Hasan²,

Safri³

et al. 2018

IJCTR

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: Acute coronary syndrome (ACS) is a medical emergency that requires immediate hospitalization and is a major cardiovascular problem because it leads to hospital care and high mortality. Mean platelet volume (MPV) values reflecting platelet activation and fibrinogen as a prothrombotic factor are expected to provide early information about the overall risk of the patient given the limited time of diagnostic efficiency of cardiactroponin.

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“…Recent studies have shown that T-cells also have an impact on tissue damage [12][13][14][15][16][17][18][19][20]. Several studies have seen that an attenuation of the inflammatory process could be a possible way to widen the therapeutic window after the acute event [8,11,12].…”

Section: Introductionmentioning

confidence: 99%

“…High fibrinogen plasma levels are considered as an independent predictor of myocardial infarction and ischemic stroke [16][17][18], furthermore Potpara and colleagues identified the association of plasma high fibrinogen levels with poor functional 30-day outcome in ischemic stroke [19].…”

Section: Introductionmentioning

confidence: 99%