Fibrinogen and Factor Xiii in Pregnancy

Pavlovskaya, Yuliya; Vorobyeva, N.A.

doi:10.17238/issn2308-3174.2015.1.68

Vestnik of N(A)FU

2015

DOI: 10.17238/issn2308-3174.2015.1.68

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Fibrinogen and Factor Xiii in Pregnancy

Yuliya Pavlovskaya¹,

N.A. Vorobyeva²

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Cited by 3 publications

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“…Factor XIII in its active state is involved in the formation of a polymer in the form of white threads from fibrin monomer, and also protects the resulting clot from lysis. This factor exists in two forms: plasma and intracellular [3]. ***…”

mentioning

confidence: 99%

Hemocoagulation factors

Korneeva,

Taranukha,

Gusakova

2023

ТРНиО

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mentioning

confidence: 99%

Hemocoagulation factors

Korneeva,

Taranukha,

Gusakova

2023

ТРНиО

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Newborn weight is associated with the maternal F13A1 gene rs5985 polymorphism

Головченко

Abramova

Ponomarenko

et al. 2021

Akušerstvo, ginekologiâ i reprodukciâ

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Aim: to evaluate a relationship between newborn weight and single-nucleotide polymorphisms rs5918 ITGB3, rs1126643 ITGA2, rs5985 F13A1 in pregnant women with preeclampsia (PE) and fetal growth retardation (FGR).Materials and Мethods. In this prospective comparative study, molecular genetic testing for the three polymorphic loci of hereditary thrombophilia candidate genes – rs1126643 ITGA2, rs5918 ITGB3, and rs5985 F13A1 was performed in 70 pregnant women with PE and FGR. Newborn somatometry was performed using standard methods. To assess functional effects of the rs5985 polymorphism of the F13A1 gene associated with newborn weight, we applied online bioinformatic programs GTEx Portal and HaploReg (assessing a relationship between polymorphism and level of gene transcription and related epigenetic effects).Results. The rs5985 polymorphism of the maternal F13A1 gene is associated with newborn weight according to allelic (â = 156.60; pperm = 0.05) and additive (â = 155.20; pperm = 0.05) genetic models. The polymorphic locus rs5985 of the F13A1 gene is characterized by pronounced pleiotropic regulatory effects in vivo: it determines the amino acid substitution in the A1 subunit of coagulation factor XIII (Val35Leu), associated with the activity of blood clotting factor XIII, localized in the DNase 1 hypersensitivity region, determines DNA affinity to 11 transcription factors (AP-2, CACD, EBF, ERalpha-a, ESR2, Hic1, Klf4, Klf7, SP1, ESR1 and TFAP2C), located in the region of modified histones, marking enhancers and promoters in the culture of ectoderm, endoderm and mesoderm cells, placenta, fetal brain and adrenal glands, progenitor cells and myoblasts in skeletal muscle, adipocytes, brain etc.Conclusion. The rs5985 polymorphism of the F13A1 gene in pregnant women with PE and FGR is associated with newborn weight.

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Using Terlipressin Aimed to Reduce Blood Loss in Cesarean Section

Александрович¹,

Rostovtsev²,

Кононова³

et al. 2018

VAIR

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Цель исследования: оценка влияния агонистов V1-вазопрессиновых рецепторов (терлипрессин) при оперативном родоразрешении у родильниц с высоким риском развития кровотечения при операции кесарева сечения� Материал и методы. Обследовано 60 женщин, родоразрешенных путем кесарева сечения в плановом порядке, средний возраст которых составил 32,7 года, срок гестации-38 недель� В 1-ю группу (n = 30) включены пациентки, оперированные без применения препарата «Терлипрессин», 2-ю группу (n = 30) составили женщины, которым интраоперационно сразу после пересечения пуповины внутриматочно (в место разреза на матке) вводили терлипрессин в дозе 0,4 мг� Интраоперационно измеряли объем кровопотери� Артериальное давление и показатели гемодинамики оценивали во время операции и через 24 ч после операции в утренние часы� Результаты. Выявлена статистически значимая разница в объеме интраоперационной кровопотери и потребности в гемотрансфузии� Терлипрессин приводил к уменьшению кровопотери на 37-50%, что обусловлено его фармакологическими эффектами-сосудосуживающим и кровоостанавливающим� Выводы. Использование терлипрессина в комплексной интенсивной терапии при операции кесарева сечения у пациенток с высоким риском развития кровотечения позволяет существенно уменьшить объем интраоперационной кровопотери и снизить трансфузию компонентов донорской крови� Ключевые слова: терлипрессин, кесарево сечение, интраоперационная кровопотеря, сохранение крови при кесаревом сечении, беременные высокого риска, акушерское кровотечение

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Fibrinogen and Factor Xiii in Pregnancy

Cited by 3 publications

References 0 publications

Hemocoagulation factors

Hemocoagulation factors

Newborn weight is associated with the maternal F13A1 gene rs5985 polymorphism

Using Terlipressin Aimed to Reduce Blood Loss in Cesarean Section

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