Fibrinogen concentrations predict long‐term cognitive outcome in young ischemic stroke patients

Pedersén, Annie; Stanne, Tara M.; Redfors, Petra; Viken, Jo I.; Samuelsson, Hans; Nilsson, Staffan; Jood, Katarina; Jern, Christina

doi:10.1002/rth2.12078

Cited by 19 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regression model, variables for inclusion were carefully chosen, given the number of samples, to ensure parsimony of the final model. The baseline variables that were considered clinically relevant (including age, hypertension and smoking) [26] or that showed univariate relevance with the severity of WMHs (P<0.1) were entered into the multivariate regression model. P-values<0.05 were considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients

Guo¹,

Deng²,

Zhong³

et al. 2021

Aging and disease

View full text Add to dashboard Cite

The relationship between fibrinogen and white matter hyperintensities (WMHs) are inconsistent. Whether there are different relationships between WMHs and fibrinogen in disparate subtypes of cerebral small vessel disease (CSVD) remains unknown. Here, we investigated the roles of plasma fibrinogen in sporadic CSVD (sCSVD) and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients. We performed a cross-sectional study that included 74 CSVD patients (19 CADASIL and 55 sporadic) and 74 age-and gender-matched healthy controls (HCs). Plasma fibrinogen was determined, and the severity of WMHs in CSVD patients was rated according to Fazekas scales. Univariate analysis and ordinal logistic regression were performed to evaluate the relationship between fibrinogen and the severity of WMHs in CSVD. Both CADASIL and sCSVD patients showed significantly higher plasma fibrinogen levels than HCs. No significant difference in the plasma fibrinogen level was observed between CADASIL and sCSVD. Univariate analysis and ordinal logistic regression indicated that fibrinogen is an independent risk factor for the severity of WMHs in CADASIL patients (odds ratio [OR] =1.064; 95% Confidence interval (CI, 1.004-1.127); p =0.037). However, age (odds ratio [OR] =1.093; 95% CI (1.033-1.156); P = 0.002), but not fibrinogen (odds ratio [OR] =1.004; 95% CI (0.997-1.011); P=0.262), is an independent risk factor for the severity of WMHs in sCSVD patients. Our results suggest that high levels of plasma fibrinogen are associated with the severity of WMHs in CADASIL but not in sCSVD patients, indicating that the role of fibrinogen may be different in disparate subtypes of CSVD. A better understanding of fibrinogen may yield insights into the pathogenesis of CSVD.

show abstract

Section: Discussionmentioning

confidence: 99%

Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients

Guo¹,

Deng²,

Zhong³

et al. 2021

Aging and disease

View full text Add to dashboard Cite

show abstract

“…Numerous studies have shown that higher levels of fibrinogen are associated with poor performance in diverse cognitive domains including attention [26], executive function [11, 26, 27], and memory [11, 28] depending on study design and population. In longitudinal studies, higher fibrinogen levels could predict declines in global cognition [10], executive function [29], nonverbal reasoning [27, 30], and processing speed [7, 9]. Furthermore, a high fibrinogen level was related to increased risk for dementia [14], VD [8, 14, 26], and AD [8].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment

Pyun

Ryoo

Park

et al. 2020

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background: Fibrinogen is considered a marker of vascular pathology, indicating a weakened blood-brain barrier, and has a causative role in neuroinflammation and neurodegeneration. Little is known about the relationship between fibrinogen levels and cognitive function in patients with mild cognitive impairment (MCI). We aimed to investigate differences in cognitive profiles according to plasma fibrinogen levels in patients with MCI and the influence of plasma fibrinogen levels on cognitive decline. Methods: This retrospective cohort study included 643 patients with MCI: 323 patients in the high fibrinogen (high fib) group and 320 patients in the low fibrinogen (low fib) group. A multiple linear regression model was performed to compare cognitive test performance between groups. The Cox proportional hazard model was used to analyze the hazard ratio of fibrinogen level for disease progression. Results: The high fib group demonstrated poorer performance in attention, executive function, and confrontation naming than the low fib group. After adjustment for APOE genotype, the high fib group was associated with poor attention and executive function. After adjustment for vascular risk factors including body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking history, the high fib group showed declined attention and confrontation naming ability. High fibrinogen levels did not predict disease progression to CDR 1. Conclusion: High plasma fibrinogen levels were associated with poor performance in attention in patients with MCI, regardless of APOE genotype or vascular risk factors.

show abstract

“… 29 30 Fibrinogen has been related to long-term outcome after stroke. 31 32 There have been conflicting data on the predictive value of serum bilirubin levels on the long-term risk of cardiovascular disease. While some studies are in favour of a predictive value, 33–35 others are not.…”

Section: Introductionmentioning

confidence: 99%

“…More recent studies uniformly identified age and stroke severity, usually assessed on the NIH Stroke Scale (NIHSS) or similar scales, as biomarkers of long-term functional outcome and mortality after stroke 29 30. Fibrinogen has been related to long-term outcome after stroke 31 32. There have been conflicting data on the predictive value of serum bilirubin levels on the long-term risk of cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a prospective cohort study

et al. 2020

View full text Add to dashboard Cite

IntroductionAgeing-related processes such as cellular senescence are believed to underlie the accumulation of diseases in time, causing (co)morbidity, including cancer, thromboembolism and stroke. Interfering with these processes may delay, stop or reverse morbidity. The aim of this study is to investigate the link between (co)morbidity and ageing by exploring biomarkers and molecular mechanisms of disease-triggered deterioration in patients with pancreatic ductal adenocarcinoma (PDAC) and (thromboembolic) ischaemic stroke (IS).Methods and analysisWe will recruit 50 patients with PDAC, 50 patients with (thromboembolic) IS and 50 controls at Rostock University Medical Center, Germany. We will gather routine blood data, clinical performance measurements and patient-reported outcomes at up to seven points in time, alongside in-depth transcriptomics and proteomics at two of the early time points. Aiming for clinically relevant biomarkers, the primary outcome is a composite of probable sarcopenia, clinical performance (described by ECOG Performance Status for patients with PDAC and the Modified Rankin Scale for patients with stroke) and quality of life. Further outcomes cover other aspects of morbidity such as cognitive decline and of comorbidity such as vascular or cancerous events. The data analysis is comprehensive in that it includes biostatistics and machine learning, both following standard role models and additional explorative approaches. Prognostic and predictive biomarkers for interventions addressing senescence may become available if the biomarkers that we find are specifically related to ageing/cellular senescence. Similarly, diagnostic biomarkers will be explored. Our findings will require validation in independent studies, and our dataset shall be useful to validate the findings of other studies. In some of the explorative analyses, we shall include insights from systems biology modelling as well as insights from preclinical animal models. We anticipate that our detailed study protocol and data analysis plan may also guide other biomarker exploration trials.Ethics and disseminationThe study was approved by the local ethics committee (Ethikkommission an der Medizinischen Fakultät der Universität Rostock, A2019-0174), registered at the German Clinical Trials Register (DRKS00021184), and results will be published following standard guidelines.

show abstract

Fibrinogen concentrations predict long‐term cognitive outcome in young ischemic stroke patients

Cited by 19 publications

References 34 publications

Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients

Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients

Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment

Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a prospective cohort study

Contact Info

Product

Resources

About