Fibrinogen Fractions in the Third Trimester of Pregnancy and in Puerperium

Adler, Grażyna; Duchiński, T.; Jasińska, Alicja; Piotrowska, Urszula

doi:10.1016/s0049-3848(99)00190-5

Cited by 23 publications

(13 citation statements)

References 23 publications

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“…A statistically significant increase in fibrinogen expression was observed at the end of pregnancy. This tendency was also observed by Heuwieser et al (1990) in cows and women (Adler et al, 2000). The latter author reported its decrease in the postnatal period, which was also noted in our experiment.…”

Section: Discussionsupporting

confidence: 91%

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Kurpińska

Jarosz²,

Ożgo³

et al. 2016

Turk J Biol

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details of feeding shown in Table 1). Blood, the material for analysis, was drawn from the external jugular vein and collected using sterile needles and tubes with anticoagulant (EDTA K 3). Collection of samples was performed at the following points: 30, 14, and 7 days before parturition and 1, 7, 14, 30, and 60 days after calving. Blood was collected each time from the same animals, and groups were formed according to the sampling date; thus, each experimental group consisted of 10 animals. The total number of samples was 80. Blood samples were centrifuged (3000 rpm, 4 ºC), and the resulting plasma samples were stored at-80 °C until analysis. The local ethics committee for experiments on animals in Szczecin approved the design of the experiment (resolution no.

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Section: Discussionsupporting

confidence: 91%

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Kurpińska

Jarosz²,

Ożgo³

et al. 2016

Turk J Biol

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“…During pregnancy, there are considerable changes in the anatomy and physiology of blood flow. In the third trimester of a normal pregnancy, a shift in the concentration of coagulation factors develops with an average increase of twofold normal plasma levels of fibrinogen, with postpartum levels returning to normal . VWF levels increase during the third trimester of pregnancy as well, while ADAMTS13 levels can decrease to 25% activity, placing pregnant women with a history of TTP at a higher risk of recurrence .…”

Section: Adamts13 Deficiency and Other Microangiopathiesmentioning

confidence: 99%

ADAMTS13: origins, applications, and prospects

et al. 2018

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ADAMTS13 is an enzyme that acts by cleaving prothrombotic von Willebrand factor (VWF) multimers from the vasculature in a highly regulated manner. In pathologic states such as thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies (TMAs), VWF can bind to the endothelium and form large multimers. As the anchored VWF chains grow, they provide a greater surface area to bind circulating platelets (PLTs), generating unique thrombi that characterize TTP. This results in microvasculature thrombosis, obstruction of blood flow, and ultimately end-organ damage. Initial presentations of TTP usually occur in an acute manner, typically developing due to an autoimmune response toward, or less commonly a congenital deficiency of, ADAMTS13. Triggers for TMAs that can be associated with ADAMTS13 deficiency, including TTP, have been linked to events that place a burden on hemostatic regulation, such as major trauma and pregnancy. The treatment plan for cases of suspected TTP consists of emergent therapeutic plasma exchange that is continued on a daily basis until normalization of PLT counts. However, a subset of these patients does not respond favorably to standard therapies. These patients necessitate a better understanding of their diseases for the advancement of future therapeutic options. Given ADAMTS13's key role in the cleavage of VWF and the prevention of PLT-rich thrombi within the microvasculature, future treatments may include anti-VWF therapeutics, recombinant ADAMTS13 infusions, and ADAMTS13 expression via gene therapy.

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“…Fibrinogen levels rise significantly during pregnancy, and the use of non-pregnant reference intervals may underestimate the prevalence of DIC. 44,45 A fibrinogen level less than 3g/L together with platelet count less than 50 and prolonged PT and APTT is consistent with DIC in pregnancy. A pregnancy modified score taking into account the physiological changes in PT, fibrinogen and platelets reported a sensitivity of 88% and specificity of 96% for the diagnosis of DIC.…”

Section: Measures Of Coagulopathymentioning

confidence: 61%

“…Mellouli et al 54 19 79 a 53 a 100 a -100 -63 a -5 8 Dwivedi et al 55 7 100 57 100 -100 -100 100 57 Nelson et al 46 51 100 18 a -9 8 a 100 -96 a 48 a 48 Zhou et al 56 28 100 75 --100 -82 100 21 Cheng et al 45 32 100 ---100 -81 100 16 Xiong et al 57 25 100 -a -92 96 -72 100 a 20 Zhang et al 44 56 88 57 a --a 88 -52 a 54 a 32 Wang et al 58 52 90 42 9.6 81 85 -71 87 -Axe et al 59 20…”

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Physiological changes of pregnancy and the Swansea criteria in diagnosing acute fatty liver of pregnancy

Morton

Laurie

2018

Obstet Med

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The Swansea criteria are used to assess the likelihood of acute fatty liver of pregnancy. There are significant physiological changes in normal pregnancy in several of the pathology parameters used in the Swansea criteria. This may impact the sensitivity and specificity of the Swansea criteria. Five of the 11 case series reporting laboratory values in acute fatty liver of pregnancy used values divergent from the Swansea criteria. When using the Swansea criteria for diagnosis of acute fatty liver of pregnancy, using pregnancy-specific and/or laboratory-specific reference intervals is recommended. Simpler diagnostic criteria using parameters of hepatocellular damage and hepatic synthetic dysfunction may be an alternative to the Swansea criteria, and further studies investigating the sensitivity and specificity of these parameters would be useful.

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Fibrinogen Fractions in the Third Trimester of Pregnancy and in Puerperium

Cited by 23 publications

References 23 publications

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

ADAMTS13: origins, applications, and prospects

Physiological changes of pregnancy and the Swansea criteria in diagnosing acute fatty liver of pregnancy

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