Fibrinogen levels in relation to colorectal cancer onset: A nested case-cohort study from the Moli-sani cohort

Parisi, Roberta; Panzera, Teresa; Russo, Laura; Gamba, Sara; Curtis, Amalia De; Castelnuovo, Augusto Di; Marchetti, Marina; Cerletti, Chiara; Falanga, Anna; Gaetano, Giovanni de; Donati, Maria Benedetta; Iacoviello, Licia; Costanzo, Simona

doi:10.3389/fcvm.2022.1009926

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…This finding supports the chronic low-level inflammation as a latent contributor of cancer development (30,31). A nested case-cohort study indicated that fibrinogen (≥400 mg/dl) was positively correlated with CRC, suggesting that it may be a latent biomarker of CRC and supporting the "common soil" hypothesis (32). Advanced adenoma, a precursor of CRC, also showed an increased risk associated with elevated fibrinogen levels in our study.…”

Section: Discussionsupporting

confidence: 88%

Relationship between fibrinogen level and advanced colorectal adenoma among inpatients: A retrospective case-control study

Wang

Zheng²,

Cao

et al. 2023

Front. Med.

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ObjectiveThis study was to explore the relationship between fibrinogen and advanced colorectal adenoma among inpatients.MethodsFrom April 2015 to June 2022, 3738 participants (566 case subjects and 3172 control subjects) who underwent colonoscopies enrolled, and smooth curve fitting and logistic regression models were applied to explore the association between fibrinogen and advanced colorectal adenoma. In addition, sensitivity and subgroup analyses were performed to assess the stability of the results.ResultsCompared with lower fibrinogen quantile 1 (< 2.4 g/L), the adjusted OR values for fibrinogen and advanced colorectal adenoma in quantile 2 (2.4–2.75 g/L), quantile 3 (2.76–3.15 g/L), and quantile 4 (≥3.16 g/L) were 1.03 (95% confidence interval [CI]: 0.76–1.41), 1.37 (95% CI: 1.01–1.85), and 1.43 (95% CI: 1.06–1.94), respectively. A linear relationship between fibrinogen and advanced colorectal adenoma was observed. Sensitivity and subgroup analyses showed stable results.ConclusionComplements the evidence that fibrinogen was positively associated with advanced adenomas, suggesting that fibrinogen may play a role in the adenoma-carcinoma sequence.

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Section: Discussionsupporting

confidence: 88%

Relationship between fibrinogen level and advanced colorectal adenoma among inpatients: A retrospective case-control study

Wang

Zheng²,

Cao

et al. 2023

Front. Med.

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“…14,30,31 In addition, few studies from general adult population reported that high levels of fibrinogen were as-sociated with increased risk of fatal and not fatal colorectal, breast and lung cancers. 13,32 In the present study, no relevant associations were found with cancer mortality in either gender.…”

Section: N O N -C O M M E R C I a L U S E O N L Ycontrasting

confidence: 78%

Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study

Parisi

Costanzo²,

Laat-Kremers³

et al. 2023

Bleed Thromb Vascul Biol

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Epidemiological data on the association between fibrinogen levels and mortality are scarse and controversial. Longitudinal analyses were performed, separately by sex, on 17,689 individuals from the Moli-sani study [53% women, ≥35 years, free from cardiovascular disease (CVD) or cancer at enrolment], to evaluate the association between plasma fibrinogen and all-cause and cause-specific mortality. Over a median follow-up of 11.2 years, 1,058 deaths (34.7% CVD, 36.3% cancer) were ascertained. Both in the lowest (1.12-2.64 g/L) and highest (≥3.62 g/L) fibrinogen quintiles, women had an increased all-cause mortality hazard, when compared with third quintile (2.97-3.23 g/L). Dose-response analyses showed a U-shaped relationship in women (P overall <0.0001; P non-linear association <0.0001), but a positive linear association for all-cause mortality in men (P overall 0.0038; P non-linear association 0.76). Similar trends for a U-shaped association were observed for CVD mortality, while no association was observed with cancer deaths. A U-shaped association of fibrinogen levels with other-cause mortality was also found in both sexes. This study shows that not only higher but also lower fibrinogen levels represent hazard for mortality when compared to normal levels; U-shaped curves being prevalently observed in women.

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“…Moreover, the complex cross-talk between the activation of coagulation and inflammation in cancer has received much attention. Abnormal hypercoagulable condition is often observed in most cancer patients (41). FIB is a glycoprotein in coagulation and is synthesized by the hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a new prognostic immune–inflammatory–nutritional score for predicting outcomes after curative resection for intrahepatic cholangiocarcinoma: A multicenter study

et al. 2023

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BackgroundImmune function, nutrition status, and inflammation influence tumor initiation and progression. This was a retrospective multicenter cohort study that investigated the prognostic value and clinical relevance of immune-, inflammatory-, and nutritional-related biomarkers to develop a novel prognostic immune–inflammatory–nutritional score (PIIN score) for patients with intrahepatic cholangiocarcinoma (ICC).MethodsThe clinical data of 571 patients (406 in the training set and 165 in the validation set) were collected from four large hepato-pancreatico-biliary centers of patients with ICC who underwent surgical resection between January 2011 and September 2017. Twelve blood biomarkers were collected to develop the PIIN score using the LASSO Cox regression model. The predictive value was further assessed using validation datasets. Afterward, nomograms combining the PIIN score and other clinicopathological parameters were developed and validated based on the calibration curve, time-dependent AUC curves, and decision curve analysis (DCA). The primary outcomes evaluated were overall survival (OS) and recurrence-free survival (RFS) from the day of primary resection of ICC.ResultsBased on the albumin–bilirubin (ALBI) grade, neutrophil- to- lymphocyte ratio (NLR), prognostic nutritional index (PNI), and systemic immune- inflammation index (SII) biomarkers, the PIIN score that classified patients into high-risk and low-risk groups could be calculated. Patients with high-risk scores had shorter OS (training set, p < 0.001; validation set, p = 0.003) and RFS (training set, p < 0.001; validation set, p = 0.002) than patients with low-risk scores. The high PIIN score was also associated with larger tumors (≥5 cm), lymph node metastasis (N1 stage), multiple tumors, and high tumor grade or TNM (tumor (T), nodes (N), and metastases (M)) stage. Furthermore, the high PIIN score was a significant independent prognostic factor of OS and RFS in both the training (p < 0.001) and validation (p = 0.003) cohorts, respectively. A PIIN-nomogram for individualized prognostic prediction was constructed by integrating the PIIN score with the clinicopathological variables that yielded better predictive performance than the TNM stage.ConclusionThe PIIN score, a novel immune–inflammatory–nutritional-related prognostic biomarker, predicts the prognosis in patients with resected ICC and can be a reliable tool for ICC prognosis prediction after surgery. Our study findings provide novel insights into the role of cancer-related immune disorders, inflammation, and malnutrition.

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Fibrinogen levels in relation to colorectal cancer onset: A nested case-cohort study from the Moli-sani cohort

Cited by 8 publications

References 47 publications

Relationship between fibrinogen level and advanced colorectal adenoma among inpatients: A retrospective case-control study

Relationship between fibrinogen level and advanced colorectal adenoma among inpatients: A retrospective case-control study

Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study

Development and validation of a new prognostic immune–inflammatory–nutritional score for predicting outcomes after curative resection for intrahepatic cholangiocarcinoma: A multicenter study

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