Aim. The article deals with studying the features of the peripheral component of erythron and cytokine profile in the blood of students with different modes of physical activity during psycho-emotional stress associated with exams in distance education. Materials and methods. The study involved 48 students aged 26.13 ± 0.48 years. To assess the concentration of erythron elements, the Cell-Dyne 3700 automated analyzer was used. The content of cytokines in blood serum was determined with the help of the Multiscane Biotech analyzer using reagent kits of the Cytokine company (St. Petersburg). Results. The features of the peripheral component of erythron and the cytokine profile were established in the peripheral blood of distant students. The severity of changes in anti- and pro-inflammatory cytokines was determined. The revealed changes can be partially eliminated when aerobic training is included in e-learning programs. Conclusion. The results of the study made it possible to identify dysfunctions of the erythron and cytokine profile in distant students and to show the high efficiency of aerobic training in terms of increasing the hematological and neuroimmune reserve of the body under stress. The effects of aerobic training are considered as an adaptive resource that indirectly affects an optimal balance between the content of pro-inflammatory and anti-inflammatory cytokines and elements of the erythron in peripheral blood in distant students.