2024
DOI: 10.1016/j.gendis.2023.06.033
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Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

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Cited by 8 publications
(5 citation statements)
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“…Selective peroxisome proliferator-activated receptor α modulator pemafibrate's promising preventive and protective effects have been confirmed in murine models of retinal I/R injury, carotid artery occlusion-induced ischemic retinopathy, streptozotocin-induced DR, and pathological ocular angiogenesis (CNV and retinal neovascularization) with increases in the serum levels of fibroblast growth factor 21 (FGF21), an important metabolic regulatory hormone [135], and decreases in inflammatory responses [136][137][138][139][140]. In the oxygen-induced retinopathy and retinal I/R injury models, pemafibrate treatment reduces pathologic HIF expression in the eye.…”
Section: Palmitoylethanolamide and Peroxisome Proliferator-activated ...mentioning
confidence: 98%
“…Selective peroxisome proliferator-activated receptor α modulator pemafibrate's promising preventive and protective effects have been confirmed in murine models of retinal I/R injury, carotid artery occlusion-induced ischemic retinopathy, streptozotocin-induced DR, and pathological ocular angiogenesis (CNV and retinal neovascularization) with increases in the serum levels of fibroblast growth factor 21 (FGF21), an important metabolic regulatory hormone [135], and decreases in inflammatory responses [136][137][138][139][140]. In the oxygen-induced retinopathy and retinal I/R injury models, pemafibrate treatment reduces pathologic HIF expression in the eye.…”
Section: Palmitoylethanolamide and Peroxisome Proliferator-activated ...mentioning
confidence: 98%
“… 7 Of the 22 subtypes of FGFs, FGF21 is a stress-related protein molecule that regulates lipid metabolism, glycogen homeostasis, and muscle development. 8 , 9 , 10 Moreover, as a myogenic regulator closely related to muscle metabolism, FGF21 secretion is an adaptive regulatory measure that regulates metabolic homeostasis in muscle, especially in the context of stresses, such as muscle mitochondrial dysfunction and endoplasmic reticulum stress. 11 , 12 FGF21 plays a role in cardiomyocyte function, as manifested by increased cardiac fibrosis deposition and mitochondrial morphology damage in an FGF21-KO mouse model of diabetic cardiomyopathy.…”
Section: Introductionmentioning
confidence: 99%
“…Myonectin and fibroblast growth factor-21 (FGF-21), linking muscle with glucose and lipid metabolism, also emerge as significant players in metabolic regulation, potentially affecting bone metabolism [25,26]. Although the exact mechanisms underlying these associations remain unclear, it is suggested that decreased levels of these myokines can lead to reduced bone mineral density and impaired bone formation [27,28].…”
Section: Introductionmentioning
confidence: 99%