Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients

Nokeety, Mahmoud M El; Heikal, Ahmed A.; Abdulazim, Dina O.; Naguib, Mervat; Din, Usama A.A. Sharaf El

doi:10.1080/0886022x.2018.1455594

Cited by 21 publications

(15 citation statements)

References 28 publications

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“…The association between FGF23 and insulin deficiency (type 1 diabetes) and resistance (type 2 diabetes) is, however, complex. In many cross‐sectional studies, FGF23 is positively correlated with obesity, diabetes or HOMA‐IR, a parameter indicating insulin resistance . According to other studies, FGF23 is inversely associated with insulin resistance .…”

Section: Homeostatic Regulation Of Fgf23mentioning

confidence: 97%

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

et al. 2019

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Fibroblast growth factor 23 (FGF23) is mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho. FGF23 can exert several endocrine functions, such as inhibiting renal phosphate reabsorption and 1,25‐dihydroxyvitamin D3 production. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. Klotho and Fgf23 deficiencies result in pathologies otherwise encountered in age‐associated diseases, mainly as a result of hyperphosphataemia‐dependent calcification. FGF23 levels are also perturbed in the plasma of patients with several disorders, including kidney or cardiovascular diseases. Here, we review mechanisms controlling FGF23 production and discuss how FGF23 regulation is perturbed in disease.

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Section: Homeostatic Regulation Of Fgf23mentioning

confidence: 97%

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

et al. 2019

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“…A lot of evidence has revealed that 1,25(OH)2D3 is closely related to the occurrence of autoimmune diseases ( 6 , 7 ). Vitamin D can inhibit inflammation and immune reaction, promote synthesis and secretion of insulin and increase insulin sensitivity ( 8 ). A review has revealed that vitamin D deficiency has a potential influence on T1DM incidence, complications and progression ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus

Liu

Wang

Wan

et al. 2018

Endocrine Connections

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BackgroundTo investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM).MethodsA case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls.ResultsThe mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05).ConclusionVitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children.

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“…In our study, FGF23 was not correlated with parameters of carbohydrate metabolism and body composition. In a previous study by Fayed et al (2018), FGF23 was found to be an important predictor of IR in CKD patients. In contrast, Hanks et al (2015) found that FGF23 was not correlated with IR in a group of patients with CKD.…”

Section: Discussionmentioning

confidence: 79%

Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease

Marchelek-Myśliwiec¹,

Dziedziejko²,

Dołęgowka³

et al. 2020

J Appl Biomed

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Insulin resistance (IR) is characterised by increased gluconeogenesis in the liver and the resistance of peripheral receptors to insulin. Several factors, including IR, type 2 diabetes, new-onset diabetes after transplant (NODAT) and secondary parathyroidism, are related to chronic kidney disease (CKD). These factors are associated with higher mortality due to the increased risk of cardiovascular complications. Many factors have been identified as potential markers of IR in CKD. These factors include fibroblast growth factors (FGFs), a subfamily of endocrine polypeptides. In this study, we examined the association of FGF19, FGF21 and FGF23 with selected parameters related to carbohydrate metabolism and insulin resistance in non diabetic patients with predialysis CKD and in non diabetic patients after renal transplantation.The study included 108 non diabetic subjects: 40 patients with predialysis CKD, 45 patients with CKD who had undergone renal transplantation, and 23 healthy subjects (control group).In patients who had undergone renal transplantation, concentrations of FGF23 were increased compared to the control group and patients with predialysis CKD. The highest and lowest FGF19 concentrations were observed in CKD patients and in patients who had undergone kidney transplantation, respectively. This difference was statistically significant. Leptin concentrations were higher in CKD patients compared to the control group and patients who had undergone kidney transplantation. There were no statistically significant differences in adiponectin concentrations, lean body mass or fat tissue mass between the studied groups. HOMA-IR and insulin levels were significantly increased in CKD patients and in patients who had undergone renal transplantation in comparison to the control group.The results of the study suggest the involvement of FGF in carbohydrate metabolism and insulin resistance in patients with predialysis CKD, as well as a correlation with kidney function. Highlights:• Insulin resistance is characterised by increased gluconeogenesis. • Chronic kidney disease (CKD) is associated with insulin resistance. • Fibroblast growth factors are involved in carbohydrate metabolism and insulin resistance in patients with predialysis CKD.

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Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients

Cited by 21 publications

References 28 publications

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus

Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease

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