2010
DOI: 10.3233/jad-2010-091522
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Fibroblasts from PS1 Mutated Pre-Symptomatic Subjects and Alzheimer's Disease Patients Share a Unique Protein Levels Profile

Abstract: In Alzheimer's disease (AD), a major goal is to improve early detection, as the diagnosis cannot be made until patients exhibit a noticeable decline in cognition and the brain is irreversibly damaged. With this aim in mind, we performed proteome analysis of familial AD fibroblasts from both demented and pre-symptomatic subjects, using a 2D-PAGE based approach and then identifying proteins by mass spectrometry. We compared primary fibroblast cultures from skin biopsy of presenilin 1 (PS1) mutated patients, pre-… Show more

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Cited by 8 publications
(12 citation statements)
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“…This is consistent with the finding that the protein expression profile from the presymptomatic PS1 mutation carriers differs significantly from that of age-matched noncarriers (43). Greater cortical florbetapir binding on PET analysis has been reported in asymptomatic PS1 mutation carriers compared with age-matched noncarriers at approximately 20 y before the predicted median age of onset of mild cognitive impairment (44).…”
Section: Discussionsupporting
confidence: 80%
“…This is consistent with the finding that the protein expression profile from the presymptomatic PS1 mutation carriers differs significantly from that of age-matched noncarriers (43). Greater cortical florbetapir binding on PET analysis has been reported in asymptomatic PS1 mutation carriers compared with age-matched noncarriers at approximately 20 y before the predicted median age of onset of mild cognitive impairment (44).…”
Section: Discussionsupporting
confidence: 80%
“…Recently, ubiquilin-1 was reported to regulate the proteasomal degradation of proteins, including presenilin (15). Since the proteasome is responsible for the removal of oxidatively damaged proteins in the cytosol and nucleus during oxidative stress (16), it is plausible that presenilin 1 protein may be degraded by the ubiquitin proteasome pathway (17). Various herbs and spices may accelerate this degradation.…”
Section: Resultsmentioning
confidence: 99%
“…In particular, the use of skin fibroblasts represents an exceptional complementary tool for investigating these neurodegenerative processes [ 38 , 39 , 41 , 204 ]. These cells can recapitulate early pathological events shown in the brains of AD, PD, HD, and ALS patients [ 38 , 39 , 41 , 204 ].…”
Section: Skin Fibroblasts: a Model To Study Pathological Changes In A...mentioning
confidence: 99%