2009
DOI: 10.3892/or_00000646
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Fibroblasts from Werner syndrome patients: Cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis

Abstract: Abstract. Werner syndrome (WS) results from defects in the gene encoding WRN RecQ helicase. WS fibroblasts undergo premature senescence in culture. Because cellular senescence is a tumor suppressor mechanism, we examined whether WS fibroblasts exhibited reduced tumorigenicity, in comparison to control cells, in a model of experimental conversion of normal human cells to cancer cells. The combination of oncogenic Ras (Ha-Ras V12G ) and SV40 large T antigen (SV40 LT) causes human cells to acquire neoplastic prop… Show more

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