Fibromatoses and Diabetes Mellitus

Kay, N. R. M.; Slater, David

doi:10.1016/s0140-6736(81)90544-4

Cited by 33 publications

(20 citation statements)

References 6 publications

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“…Inflammation in turn affects the subacroniial bursa, coracohumerdl ligament, and joint capsule, finally causing shoulder contracture [17]. Histological examination revealed that in the glenohumeral capsule with contracture, fibroblasts and blood vessels proliferate, but not in the synovium [12,14]. Tamai et al compared the inflammatory activity of the SAB with that of glenohumeral joint (GHJ) in idiopathic contracture using enhanced MRI.…”

Section: Discussionmentioning

confidence: 99%

Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease

Handa

Gotoh

Hamada

et al. 2003

Journal Orthopaedic Research

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Vascular endothelial growth factor (VEGF) is a glycoprotein that plays an important role in neovascularization and increases vascular permeability. We reported that VEGF is involved in motion pain of patients with rotator cuff disease by causing synovial proliferation in the subacromial bursa (SAB). The present study investigates whether VEGF is also involved in the development of shoulder contracture in diabetics with rotator cuff disease. We examined 67 patients with rotator cuff disease, including 36 with complete cuff tears, 20 with incomplete tears, and 11 without apparent tears (subacromial bursitis). The patients were into groups according to the presence or absence of diabetes (14 type I1 diabetics and 53 non-diabetics). Specimens of the synovium of the SAB were obtained from all patients during surgery. Expression of the VEGF gene in the synovium of the subacromial bursa was evaluated by using the reverse transcriptase polymerase chain reaction. The VEGF protein was localized by immunohistochemistry, and the number of vessels was evaluated based on CD34 immunoreactivity. The results showed that VEGF mRNA was expressed in significantly more diabetics (100'%1, 14/14) than in non-diabetics (70'%,, 37/53) ( P = 0.01 59, Fisher's test). Investigation of VEGF isoform expression revealed VEGF121 in all 14 diabetics and in 37 of the 53 non-diabetics, VEGF165 in 12 of the 14 diabetics and in 21 of the 53 non-diabetics, and VEGF189 in 1 of the 14 diabetics and in 2 of the 53 non-diabetics. No VEGF206 was expressed in either group. VEGF protein was localized in both vasc~ilar endothelial cells and synovial lining cells. The mean number of VEGFpositive vessels and the vessel area were also significantly greater in the diabetics ( p < 0.015, Mann-Whitney U test). Synovial proliferation and shoulder joint contracture were more common in the diabetics ( P = 0.0329 and P = 0.073, respectively; Fisher's test). The mean preoperative range of shoulder motion significantly differed in terms of elevation between two groups: 103.8" in diabetics and 124.9" in no diabetics ( p = 0.0039 Mann-Whitney U test). In contrast, external rotation did not significantly differ: 44" in diabetics and 49" in non-diabetics ( p = 0.4957, Mann-Whitney U test). These results suggest that VEGF121 and VEGF165 expression in the SAB is responsible for the development of shoulder joint contracture, especially in elevation, among type 11 diabetic patients with rotator cuff disease.

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Section: Discussionmentioning

confidence: 99%

Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease

Handa

Gotoh

Hamada

et al. 2003

Journal Orthopaedic Research

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“…In der neueren Literatur werden Korrelationen der ¹frozen shoulderª mit dem Diabetes mellitus, der Dupuytrenschen Kontraktur sowie mit dem Krankheitsbild der Hyperthyreose beschrieben [3,6,8,12].…”

Section: Discussionunclassified

Die „frozen shoulder“Arthroskopische, histologische und elektronenmikroskopische Untersuchungen

Kilián¹,

Kriegsmann²,

Berghäuser³

et al. 2001

Chirurg

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“…The term "frozen shoulder" was introduced by Codman in 1934 2 . Idiopathic adhesive capsulitis is now more narrowly defined as a frozen shoulder with severe and global loss of range of motion (ROM) with unknown etiology [3][4][5] .…”

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confidence: 99%