Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin α5β1/αvβ3-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells

Jin, Young-June; Park, Iha; Hong, In‐Kee; Choi, Jeongsuk; Kim, Young‐Myeong; Lee, Hansoo

doi:10.1016/j.cellsig.2010.08.012

Cited by 77 publications

(62 citation statements)

References 45 publications

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“…Previous studies have revealed that the increase in phosphorylation of ERK and JNK may promote HUVEC migration and tubule formation (17)(18)(19). In the present study, it was demonstrated that Cthrc1 was able to promote ERK and JNK phosphorylation in HUVECs, and inhibition of ERK and JNK phosphorylation may decrease HUVEC migration and tubule formation.…”

Section: Discussionsupporting

confidence: 52%

Collagen triple helix repeat containing 1 promotes tumor angiogenesis in gastrointestinal stromal tumors

Chen

Lin

et al. 2017

Oncol Lett

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Abstract. Collagen triple helix repeat containing 1 (Cthrc1) is a secreted protein that has been observed to lead to poorer prognosis by inducing the invasion and metastasis in different tumors; however, it has not been demonstrated that Cthrc1 is involved in tumor angiogenesis. Immunohistochemical staining of Cthrc1 and CD31 in gastrointestinal stromal tumor tissue demonstrated that Cthrc1 is associated with microvascular density. Overexpression of Cthrc1 protein may alter the properties of human umbilical vein endothelial cells (HUVECs), including migration, invasion, tubule formation and aortic ring sprouting. Small interfering RNA-mediated knockdown of Cthrc1 was performed to verify the opposite effects. Migration and tubule formation induced by Cthrc1 overexpression in HUVECs was attenuated by inhibition of phosphorylation in extracellular-signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways. The pro-angiogenic effect of Cthcr1 is associated with increased phosphorylation of ERK and JNK in HUVECs. Silencing the expression of Cthrc1 protein may be a promising strategy to inhibit tumor angiogenesis.

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Section: Discussionsupporting

confidence: 52%

Collagen triple helix repeat containing 1 promotes tumor angiogenesis in gastrointestinal stromal tumors

Chen

Lin

et al. 2017

Oncol Lett

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“…It could be related to its binder hyaluronan, as there are several articles that have shown CD44 binding to hyaluronan to be able to induce cell signaling, for example through Akt phosphorylation (48). There is also the possibility of an integrinmediated signaling, using I␣I's ability to bind to vitronectin (34), as integrin-mediated attachment has been also been described to induce cell signaling such as PI3K/Akt phosphorylation (49). Moreover, recent articles have linked YAP to cellular responses induced by extracellular matrix stiffness, showing that hES cells, for example, have increased YAP nuclear localization when seeded on stiffer gels (50,51).…”

Section: Discussionmentioning

confidence: 99%

Serum Inter-α-inhibitor Activates the Yes Tyrosine Kinase and YAP/TEAD Transcriptional Complex in Mouse Embryonic Stem Cells

Pijuan-Galito

Tamm

Annerén

2014

Journal of Biological Chemistry

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Background: Serum contributes to embryonic stem (ES) cell maintenance of pluripotency and activates Yes. Results: The serum protein Inter-␣-inhibitor (I␣I) was found to activate the Yes/YAP/TEAD transcription factor pathway and induce expression of Oct3/4 and Nanog in ES cells. Conclusion: I␣I activates key pluripotency pathways. Significance: I␣I may play a significant role in ES cell maintenance and self-renewal.

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“…How theta bursts produce these effects remains to be determined although it is known that the stimulation pattern engages kinases and small GTPases (Chen et al, 2007(Chen et al, , 2010b) that regulate integrin status in various types of adhesion junctions (Munshi and Stack, 2006;Jin et al, 2011;Sil et al, 2011). Moreover, recent studies showed that LTP induction leads to focal activation of matrix metalloproteinase-9 (MMP-9; Nagy et al, 2006; Bozdagi et al, 2007), an extracellular proteinase that cleaves matrix proteins and thereby generates integrin ligands .…”

Section: Discussionmentioning

confidence: 99%

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

Babayan

Kramár

Barrett³

et al. 2012

J. Neurosci.

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Memory consolidation theory posits that newly acquired information passes through a series of stabilization steps before being firmly encoded. We report here that in rat and mouse, hippocampus cell adhesion receptors belonging to the ␤1-integrin family exhibit dynamic properties in adult synapses and that these contribute importantly to a previously unidentified stage of consolidation. Quantitative dual immunofluorescence microscopy showed that induction of long-term potentiation (LTP) by theta burst stimulation (TBS) activates ␤1 integrins, and integrin-signaling kinases, at spine synapses in adult hippocampal slices. Neutralizing antisera selective for ␤1 integrins blocked these effects. TBS-induced integrin activation was brief (Ͻ7 min) and followed by an ϳ45 min period during which the adhesion receptors did not respond to a second application of TBS. Brefeldin A, which blocks integrin trafficking to the plasma membrane, prevented the delayed recovery of integrin responses to TBS. ␤1 integrin-neutralizing antisera erased LTP when applied during, but not after, the return of integrin responsivity. Similarly, infusions of anti-␤1 into rostral mouse hippocampus blocked formation of long-term, object location memory when started 20 min after learning but not 40 min later. The finding that ␤1 integrin neutralization was effective in the same time window for slice and behavioral experiments strongly suggests that integrin recovery triggers a temporally discrete, previously undetected second stage of consolidation for both LTP and memory.

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Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin α5β1/αvβ3-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells

Cited by 77 publications

References 45 publications

Collagen triple helix repeat containing 1 promotes tumor angiogenesis in gastrointestinal stromal tumors

Collagen triple helix repeat containing 1 promotes tumor angiogenesis in gastrointestinal stromal tumors

Serum Inter-α-inhibitor Activates the Yes Tyrosine Kinase and YAP/TEAD Transcriptional Complex in Mouse Embryonic Stem Cells

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

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