Fibronectin changes in eosinophilic meningitis with blood–CSF barrier disruption

Shyu, Ling-Yuh; Hu, Ming-E; Chou, Chun-Hui; Chen, Kemin; Chiu, Ping-Sung; Lai, Shih‐Chan

doi:10.1016/j.exppara.2015.02.002

Cited by 5 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, MMPs also indirectly facilitate higher influx of leukocytes into the CP stroma by modulating the ECM, thereby making the CPE more accessible. For example, a recent study in parasitic meningitis supports a role for an increased MMP9 activity in fibronectin proteolysis, leading to BCSFB permeability and an augmented eosinophilic cell count in the CSF [109]. Given that TJs are possible substrates for MMPs, and considering the link between TJ disturbance and BCSFB impairment, the role of TJs in leukocyte transmigration should be explored further.…”

Section: Therapeutic Approaches and Caveatsmentioning

confidence: 96%

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

Demeestere

Libert

Vandenbroucke

2015

Drug Discovery Today

View full text Add to dashboard Cite

Section: Therapeutic Approaches and Caveatsmentioning

confidence: 96%

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

Demeestere

Libert

Vandenbroucke

2015

Drug Discovery Today

View full text Add to dashboard Cite

“…Fibronectin was found to be associated with adhesion in many intestinal pathogens ( 33 ). Previous studies have considered fibronectin as a biomarker for some diseases, such as sepsis, where low fibronectin levels seem to be a marker of poor prognosis, and meningitis and asthma, where fibronectin levels are significantly increased ( 34 , 35 ). But it is the first time that fibronectin could be a biomarker for calf diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves

Yan

Zhang²,

Wang³

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

Dampness heat diarrhea (DHD) is one of the most common syndromes of calf diarrhea. Its complex etiology and lack of objective diagnostic criteria bring great challenges to the diagnosis and treatment of this disease. This study aims to screen some prospective diagnostic biomarkers or therapeutic targets for calves with DHD by investigating the differential protein profiles of plasma between DHD calves and clinically healthy calves by mass spectrometry-based proteomic. A total of 120 DHD calves and 90 clinically healthy calves were divided into two groups randomly, 30 DHD calves and 30 clinically healthy calves in the test group, and 90 DHD calves and 60 clinically healthy calves in the validation group. In the test group, a total of 52 proteins were differentially expressed between calves with DHD and clinically healthy calves, 13 proteins were significantly increased and 39 proteins were significantly decreased. The differentially expressed proteins were associated with the intestinal immune network of IgA production, caffeine metabolism, purine metabolism, and PI3K signaling pathway. In the validation group, 13 proteins were selected from 52 differential expression proteins for parallel reaction monitoring validation to verify their associations with DHD calves. The targeted proteomic results showed that fibronectin precursor (FN1) and apolipoprotein C-IV precursor (APOC4) were significantly associated with DHD in calves, and they were downregulated in sick calves. In conclusion, the differential expression of plasma proteins was associated with DHD pathogenesis in calves, and the FN1 and APOC4 might be the potential clinical biomarkers for diagnosis of DHD in calves, and the intestinal immune network of IgA production, caffeine metabolism, purine metabolism, and PI3K signaling pathway are the candidate targets to treat DHD in calves. Our finding provides a reference for further investigating the pathogenesis, developing techniques of diagnosis, and screening treatment drugs for DHD in calves.

show abstract

Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

et al. 2017

View full text Add to dashboard Cite

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier's permeability is not only a cause but a consequence of brain injury in sepsis.

show abstract

Fibronectin changes in eosinophilic meningitis with blood–CSF barrier disruption

Cited by 5 publications

References 28 publications

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves

Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

Contact Info

Product

Resources

About