Fibrosis, Regeneration, and Aging

Torres, Vicente E.; Leof, Edward B.

doi:10.1681/asn.2011060603

Cited by 10 publications

(8 citation statements)

References 46 publications

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“…In particular, it is able to modulate the expression of PDGFR α and β, C-KIT and colony-stimulating factor-1 receptor [25]. All three of them are modulators of inflammatory and fibrotic processes [26]. Imatinib is nowadays used in patients with haematologic disorders such as chronic and acute myeloid leukaemia and gastrointestinal stromal tumours.…”

Section: T Y R O S I N E -K I N a S E R E C E P To R S A N D D D R -1mentioning

confidence: 99%

Discoidin domain receptor-1 and periostin: new players in chronic kidney disease

Alfieri

Kavvadas

Simonini

et al. 2015

Nephrol. Dial. Transplant.

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The incidence and prevalence of chronic kidney disease represents an important problem for public health. In renal diseases, the main histologic alterations derive from the development of renal fibrosis which results from the loss of the balance between pro- and anti-fibrotic factors. Tyrosine kinase receptors (RTKs) and matricellular proteins (MPs) are nowadays studied as potential modulators of renal injury. RTKs regulate cell cycle, migration, metabolism and cellular differentiation. Discoidin domain receptor-1 (DDR-1) is an RTK that has been extensively studied in cancer, and lung and renal diseases. It modulates inflammatory recruitment, extracellular matrix deposition and fibrosis; in renal diseases, it appears to act independently of the underlying disease. MPs regulate cell-matrix interactions and matrix accumulation, cellular adhesion and migration, and expression of inflammatory cells. Periostin is an MP, mainly studied in bone, heart, lung and cancer. Several studies demonstrated that it mediates cell-matrix interactions, migration of inflammatory cells and development of fibrosis. Recently, it has been reported in several nephropathies. In this review, we discuss the potential pathological roles of DDR-1 and periostin focussing on the kidney in both experimental models and human diseases.

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Section: T Y R O S I N E -K I N a S E R E C E P To R S A N D D D R -1mentioning

confidence: 99%

Discoidin domain receptor-1 and periostin: new players in chronic kidney disease

Alfieri

Kavvadas

Simonini

et al. 2015

Nephrol. Dial. Transplant.

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“…Autophagy, a critical homeostatic and quality control mechanism maintaining glomerular homeostasis, is noted in the aging kidney, particularly in the podocyte [9,10]. Interstitial renal fibrosis is a feature of the aging kidney and is the final common pathway for the development of ESRD that is characterized by proliferation and transformation of fibroblasts into myofibroblasts, deposition of fibronectin and collagens I and III into the interstitium, and microvascular rarefaction [11]. Aging comprises a permanent low-grade activation of the inflammatory system, dysfunctionality of T cells, defective natural killer cells, and atrophy of the thymus.…”

Section: Aging and Its Impact On The Kidneymentioning

confidence: 99%

A Review of Chronic Kidney Disease and the Immune System: A Special Form of Immunosenescence

Hsu¹,

Lang²,

Wang³

et al. 2014

J Gerontol Geriatric Res

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Immune dysregulation is a common problem and immunosenescence plays a major role in the aged population. Many chronic inflammatory diseases have the same effect in the aged such as chronic HIV-treated patients, tuberculosis patients or those with chronic kidney disease. Chronic kidney disease patients have a high incidence of vascular calcification, accelerated atherosclerosis, loss of appetite, increased muscle catabolism, renal osteodystrophy, and a high prevalence of depression because of the dysregulation of the immune system. These patients have different immune system manifestations compared with aged individuals of the same age; moreover, many geriatric syndromes are observed in this group. This review is an analysis from the nephrology perspective on the relationship between chronic kidney disease and the immune system.

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“…Many age-related conditions are linked to increased fibrosis, at least in humans (Torres and Leof, 2011). Therefore, we could expect that the MRL mice, which have reduced fibrosis, would then have increased life spans.…”

Section: Future Directionsmentioning

confidence: 99%

The super super-healing MRL mouse strain

Heydemann

2012

Front. Biol.

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The Murphy Roths Large (MRL/MpJ) mice provide unique insights into wound repair and regeneration. These mice and the closely related MRL/MpJ-Faslpr/J and Large strains heal wounds made in multiple tissues without production of a fibrotic scar. The precise mechanism of this remarkable ability still eludes researchers, but some data has been generated and insights are being revealed. For example, MRL cells reepithelialize over dermal wound sites faster than cells of other mouse strains. This allows a blastema to develop beneath the protective layer. The MRL mice also have an altered basal immune system and an altered immune response to injury. In addition, MRL mice have differences in their tissue resident progenitor cells and certain cell cycle regulatory proteins. The difficulty often lies in separating the causative differences from the corollary differences. Remarkably, not every tissue in these mice heals scarlessly, and the specific type of wound and priming affect regeneration ability as well. The MRL/MpJ, MRL/MpJ-Faslpr/J, and Large mouse strains are also being investigated for their autoimmune characteristic. Whether the two phenotypes of regeneration and autoimmunity are related remains an enigma.

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Fibrosis, Regeneration, and Aging

Abstract: cytoskeleton rearrangement through increases of intracellular

Cited by 10 publications

References 46 publications

Discoidin domain receptor-1 and periostin: new players in chronic kidney disease

Discoidin domain receptor-1 and periostin: new players in chronic kidney disease

A Review of Chronic Kidney Disease and the Immune System: A Special Form of Immunosenescence

The super super-healing MRL mouse strain

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