Ficus exasperata: effects on diabetes mellitus in an experimental rat model

Traditional uses and pharmacological potential of Ficus exasperata vahl

“…Authors concluded that the extract is useful in lowering blood lipids in experimental diabetes. [21] In an acute study, oral administered of aqueous extract of F. exasperata leaves at a dose of 2gkg -1 reduced blood glucose by 68% in alloxan induced diabetic rats at the end of 150 min duration. [59] Hypotensive Hypertension is a major risk factor for the development of coronary heart disease, peripheral vascular disease, congestive heart failure, stroke and renal failure [68] and it is one of the major causes of sudden death.…”

“…The biochemical findings were substantiated by the histopathological studies which indicated that high doses of the ethanol leaf extract could lead to toxic injury in the kidneys which might interfere with renal tubular function and induce renal failure. [20,21] In another acute toxicity study involving a Nigerian polyherbal tea containing Anthocleistavogelii, Ficus exasperata leaves and Viscum album, a 100% moratlaity was produced at the dose of 20.0g kg -1 in mice over 72h. However, no mortality occurred in animals that received <5.0g kg -1 of the extract.…”

“…The biochemical findings were substantiated by the histopathological studies which indicated that high doses of the ethanol leaf extract could lead to toxic injury in the kidneys which might interfere with renal tubular function and induce renal failure. [20,21] The present review is aimed to provide a comprehensive account of its traditional uses, pharmacological activity and toxicity in view of the many recent findings on this plant. This review serves as a collective reference for the researchers to take-up intensive toxicological evaluation and characterization of the toxicants present in F. exasperata extracts for its optimum therapeutic utilization.…”

Acute toxicity studies of the leaf extract of Ficus exasperata on haematological parameters, body weight and body temperature

“…It has also been reported that the leaves of FE lowers plasma triacyl-glycerol and ␤-hydroxyl butyrate in alloxan-induced diabetes in rats (Nimenibio-Uadia, 2003). A study by Ijeh and Agbo (2006) indicated that high doses of the ethanolic leaf extract could lead to toxic injury in the kidneys which might interfere with renal tubular function and induce renal failure.…”

Ameliorative Effects of Methanolic Extract of Ficus exasperata (Vahl.) on Carbon Tetrachloride-Induced Hepatopathy in Albino Rats

“…The leaves, stem bark, roots, flowers, and seeds of plants have been utilized in various forms for the treatment of diverse diseases. Root decoctions are taken for the treatment of urinary tract ailments, gonorrhea, asthma and tuberculosis and chewed in case of cough [12][13][14]. The leafy shoot is used in preparations applied externally against jaundice or drunk as a diuretic.…”