Ficusonic Acid: a New Cytotoxic Triterpene Isolated from<i>Maytenus royleanus</i>(Wall. ex M. A. Lawson) Cufodontis

Din, Ala Ud; Uddin, Ghias; Hussain, Nusrat; Choudary, M. Iqbal

doi:10.5935/0103-5053.20130084

Cited by 3 publications

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“…The plant is a thorny shrub with stiff branches and flowers in the month of March and April. Flowers are white in color and after maturation forms 3-gonous capsule bearing black seeds (1,2). Northern areas like the valleys of Kaghan, Kashmir, Swat and Buner are its natural habitats (1,2), where it is used in local traditional medicines as analgesic, antidiarrheal, anti-dysentric, antispasmodic, antimicrobial, gastroprotective, anticancer and as pediculicidal (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Flowers are white in color and after maturation forms 3-gonous capsule bearing black seeds (1,2). Northern areas like the valleys of Kaghan, Kashmir, Swat and Buner are its natural habitats (1,2), where it is used in local traditional medicines as analgesic, antidiarrheal, anti-dysentric, antispasmodic, antimicrobial, gastroprotective, anticancer and as pediculicidal (3,4). Despite of the widespread use of the plant in folk medicine as well as potential of the genus to display diverse pharmacological activities, a very limited number of scientific studies have been carried out on G. royleana for the validation of its folkloric uses.…”

Section: Introductionmentioning

confidence: 99%

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Antidiarrheal, Analgesic and Pediculicidal Activities of Gymnosporia royleana

Aziz¹,

Khan²,

Khan³

et al. 2016

West Indian Med J

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Objective: In order to scientifically validate the folk uses, extracts of aerial parts of Gymnosporia royleana were screened for in-vivo antidiarrheal and analgesic activity and in-vitro pediculicidal activity. Methods: Methanol extract of aerial parts of Gymnosporia royleana (GR) was screened for in-vivo antidiarrheal activity in wistar rats using castor oil induced diarrhea model, and for analgesic activity using acetic acid induced writhing and hot plat induced pain models in mice. Methanol extract and its various solvent fractions were also screened for in-vitro pediculicidal activity using human head lice. Results: In antidiarrheal assay, GR extract showed a considerable reduction in the number of wet feces as well as total number of feces in a dose dependent fashion. GR extract produced 26.55%, 77.60% and 84.06% inhibition of diarrhea at doses of 100 mg/Kg, 200 mg/Kg and 400 mg/Kg body weight. In acetic acid induced writhings model, the extract demonstrated the dose dependent analgesic effect which was highest for 600 mg/Kg body weight dose, however, it was less than that of Diclofenac sodium. In thermally induced pain model, GR extract exhibited significant analgesic effect in a dose dependent fashion and at 600 mg/Kg dose, analgesic effect was comparable to that of morphine (20 mg/Kg body weight). The pediculicidal activity of the plant extracts were found to be insignificant when compared to control. Conclusion: The results of in-vivo studies strongly support the antidiarrheal and analgesic use of the plant in folk medicine, however, in-vitro pediculicidal assay provided contradictive evidence regarding the pediculicidal use of the plant.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidiarrheal, Analgesic and Pediculicidal Activities of Gymnosporia royleana

Aziz¹,

Khan²,

Khan³

et al. 2016

West Indian Med J

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“…Many of the chemical components isolated from its species have pharmacological properties (Din et al 2013, Duarte et al 2013, Moo-Puc et al 2014 (Silva et al 2009, Rodrigues et al 2012, M. aquifolium Mart., (Gonzalez et al 2001), M. salicifolia Reissek, (Magalhães et al 2011) and M. truncata Reissek, (Silva et al 2005a) are used in folk medicine to treat the same stomach illness, and have the same popular name "espinheira-santa" (Niero et al 2011). For these reasons it is necessary a careful quality control of raw material in the manufacture of drugs using Maytenus species and is required define anatomical key characters for the unambiguous species identification (Jacomassi & Machado 2004, Duarte & Debur 2005, Joffily & Vieira 2005, Nakamura et al 2013.…”

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confidence: 99%

Leaf morphoanatomy of the medicinal <em>Maytenus imbricata</em> (Celastraceae): an ecological approach

et al. 2017

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Background: The leaves of many species of Maytenus are used to prepare herbal drugs to treat stomach ulcers. Questions: In order to define key anatomical characters for the unambiguous species identification, the present study aimed to describe the leaf morphoanatomy of M. imbricata. Species study: Maytenus imbricata Mart. ex Reissek (Celastraceae) Study site and dates: Collected in an area of 'campo rupestre' -one of the Brazilian Savannah vegetation (20º 22' 11.02" S, 43º 30' 22.81" W) in August 2015. Methods: The plant material was processed according to commonly used techniques in plant anatomy studies. Results: The major anatomical characters for several species of Maytenus identification also present in M. imbricata are marginal teeth, conspicuous epicuticular wax, ciclocytic stomata, thick external periclinal wall with large pits on epidermal cells and vascular system with a closed loop shape in cross-section. Strips on the anticlinal walls on epidermal cells and conspicuous gelatinous fibers sheath are diagnostic for M. imbricata. Conclusions: Strips on the anticlinal wall of the epidermal cell are reported for the first time for the genus. The xeromorphic traits help the species to survive in arid environments and may contribute to quality control of the raw material used in the production of herbal medicines. Keywords: cell wall strips, colleter, gelatinous fiber, xeromorphic. ResumenAntecedentes: Las hojas de muchas especies de Maytenus se utilizan para la preparación de medicamentos para el tratamiento de las úlceras de estómago. Preguntas: Con la finalidad de contribuir a la identificación de la especie, este estudio tuvo como objetivo describir la morfología y anatomia de la hoja de M. imbricata. Especie de estudio: Maytenus imbricata Mart. ex Reissek (Celastraceae) Sitio y años de estudio: Recolecta de material en una zona de 'campo rupestre' -vegetación del cerrado brasileño (20º 22' 11.02" S, 43º 30' 22.81" W) en agosto del 2015. Métodos: El material vegetal se procesó mediante las técnicas que se utilizan en los estudios de anatomía vegetal. Resultados: Los principales caracteres anatómicos para la identificación de varias especies de Maytenus, que están presentes en M. imbricata, son los dientes marginales, la cera epicuticular gruesa, los estomas ciclocíticos, las células epidérmicas con la pared periclinal externa gruesa, con grandes punteaduras y la sección transversal del sistema vascular en un círculo cerrado. Las estrías en las paredes anticlinales y las fibras gelatinosas son caracteres diagnósticos para M. imbricata. Conclusiones: Las estrías que se forman en la pared de las células epidérmicas se reportan por primera vez en el género. Estos caracteres xeromórficos ayudan a la especie a sobrevivir en ambientes áridos y pueden contribuir al control de la calidad de la materia prima utilizada en la producción de medicamentos. Palabras clave: caracteres xeromórficos, coléteres, estrías en la pared celular, fibras gelatinosas.

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Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

et al. 2022

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The Celastraceae family comprises about 96 genera and more than 1.350 species, occurring mainly in tropical and subtropical regions of the world. The species of this family stand out as important plant sources of triterpenes, both in terms of abundance and structural diversity. Triterpenoids found in Celastraceae species display mainly lupane, ursane, oleanane, and friedelane skeletons, exhibiting a wide range of biological activities such as antiviral, antimicrobial, analgesic, anti-inflammatory, and cytotoxic against various tumor cell lines. This review aimed to document all triterpenes isolated from different botanical parts of species of the Celastraceae family covering 2001 to 2021. Furthermore, a compilation of their 13C-NMR data was carried out to help characterize compounds in future investigations. A total of 504 pentacyclic triterpenes were compiled and distinguished as 29 aromatic, 50 dimers, 103 friedelanes, 89 lupanes, 102 oleananes, 22 quinonemethides, 88 ursanes and 21 classified as others.

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Ficusonic Acid: a New Cytotoxic Triterpene Isolated fromMaytenus royleanus(Wall. ex M. A. Lawson) Cufodontis

Cited by 3 publications

References 0 publications

Antidiarrheal, Analgesic and Pediculicidal Activities of Gymnosporia royleana

Antidiarrheal, Analgesic and Pediculicidal Activities of Gymnosporia royleana

Leaf morphoanatomy of the medicinal <em>Maytenus imbricata</em> (Celastraceae): an ecological approach

Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

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