Fiducial marker for prostate radiotherapy: comparison of 0.35- and 0.5-mm-diameter computed tomography and magnetic resonance images

Tanaka, Osamu; Komeda, Hisao; Iida, Takuya; Tamaki, Masayoshi; Seike, Kensaku; Kato, Daisuke; Hirose, Shigeki; Kawaguchi, Daisuke; Yokoyama, T.

doi:10.1007/s11547-016-0715-5

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Visualizations of the GMs in 3 T MRI was superior to both 1.5 T MRI in all sequences due to more susceptibility artifacts resulting in a generally slightly larger volume of the fiducial, as shown in Figure 2, Table 2 which is in line with a report from Tanaka et al [12]. Despite volume differences, the artifacts in CT or MRI did not impair contouring in both modalities.…”

Section: Discussionsupporting

confidence: 88%

“…The use of different fiducials with portal imaging or CBCT is well established in clinical routine [1,11]. However, the combination of MRI planning and the use of GMs in regard to visibility on MRI [12,13], distortion of MRI data by artifacts [14] and anisotropic deformation of MRI-sequences [15] with underestimated prostatic volumes (target miss) are currently under investigation.…”

Section: Introductionmentioning

confidence: 99%

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Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data

et al. 2018

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2019) Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data, Acta Oncologica, 58:1, 88-94, ABSTRACT Introduction: To increase precision of radiation treatment (RT) delivery in prostate cancer, MRI-based RT as well as the use of fiducials like gold markers (GMs) have shown promising results. Their combined use is currently under investigation in clinical trials. Here, we aimed to evaluate a workflow of image registration based on GMs between CT and MRI as well as weekly MRI-MRI adaption based on T2 TSE sequence. Material and methods: A gel-phantom with two inserted GMs was scanned with CT and three different MR-scanners of 1.5 and 3 T (T2 TSE and T1 VIBE-Dixon, isotropic, voxel size 2 Â 2 Â 2 mm). After image fusion, deviations for fiducial and gel match were measured and artifacts were evaluated. Additionally, CT-MRI-match deviations and MRI-MRI-match deviations of 10 Patients from the M-basePro study using GMs were assessed. Results: GMs were visible in all imaging modalities. The outer gel contours were matched with <1 mm deviation, contour volumes varied between 0 and 1%. The deviations of the GMs were less than 2 mm in any direction of MRI/CT. Shifts of peripherally or centrally located GMs were randomly distributed. The average MRI-CT-match precision of 10 patients with GMs was 1.9 mm (range 1.1-3.1 mm). Conclusions: Match inaccuracies for GMs between reference CT and voxel-isotropic T2-TSE sequences are small. Spatial deviations of CT-and MR-contoured fiducials were less than 2 mm, i.e., below SLT of the applied modalities. In patients, the average CT-MRI-match precision for GMs was 1.9 mm supporting their use in MR-guided high precision RT. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data

et al. 2018

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“…Both spin echo and gradient echo MRI sequences have been suggested to improve the signal void visibility. [20][21][22][23][24][25][26] Combinations of different MRI sequences has also been suggested. 27,28 The use of more exotic sequences to even enable a positive contrast of the metal has been developed.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have investigated different ways of detecting and visualizing a metallic structure within the patient. Both spin echo and gradient echo MRI sequences have been suggested to improve the signal void visibility . Combinations of different MRI sequences has also been suggested .…”

Section: Introductionmentioning

confidence: 99%

Registration free automatic identification of gold fiducial markers in MRI target delineation images for prostate radiotherapy

et al. 2017

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Purpose: The superior soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) has urged the integration of MRI and elimination of CT in radiotherapy treatment (RT) for prostate. An intraprostatic gold fiducial marker (GFM) appears hyperintense on CT. On T2-weighted (T2w) MRI target delineation images, the GFM appear as a small signal void similar to calcifications and post biopsy fibrosis. It can therefore be difficult to identify the markers without CT. Detectability of GFMs can be improved using additional MR images, which are manually registered to target delineation images. This task requires manual labor, and is associated with interoperator differences and image registration errors. The aim of this work was to develop and evaluate an automatic method for identification of GFMs directly in the target delineation images without the need for image registration. Methods: T2w images, intended for target delineation, and multiecho gradient echo (MEGRE) images intended for GFM identification, were acquired for prostate cancer patients. Signal voids in the target delineation images were identified as GFM candidates. The GFM appeared as round, symmetric, signal void with increasing area for increasing echo time in the MEGRE images. These image features were exploited for automatic identification of GFMs in a MATLAB model using a patient training dataset (n = 20). The model was validated on an independent patient dataset (n = 40). The distances between the identified GFM in the target delineation images and the GFM in CT images were measured. A human observatory study was conducted to validate the use of MEGRE images. Results: The sensitivity, specificity, and accuracy of the automatic method and the observatory study was 84%, 74%, 81% and 98%, 94%, 97%, respectively. The mean absolute difference in the GFM distances for the automatic method and observatory study was 1.28 AE 1.25 mm and 1.14 AE 1.06 mm, respectively. Conclusions: Multiecho gradient echo images were shown to be a feasible and reliable way to perform GFM identification. For clinical practice, visual inspection of the results from the automatic method is needed at the current stage.

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“…Interobserver variations significantly affect estimated prostate volume and shape. [4][5][6][7][8][9][10][11][12][13] Various markers are used worldwide, with diameters of 0.28-2.0 mm. The aim of using GM was to make registration of CT and MRI on radiotherapy planning and minimizing interfraction daily variation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of MRI visualization between linearly placed iron-containing and non-iron-containing fiducial markers for prostate radiotherapy

Tanaka¹,

Komeda

Tamaki

et al. 2017

BJR

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Visualization quality was similar between GA (iron-containing marker) and VIS (non-iron-containing marker) in planning CT, but was better for GA than for VIS in MRI. To achieve high-precision radiotherapy, an iron-containing gold marker was useful for CT and MRI registration. Advances in knowledge: An iron-containing fiducial marker was useful for CT and MRI registration, especially in high-precision radiotherapy, such as stereotactic body radiotherapy and intensity-modulated radiotherapy.

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Fiducial marker for prostate radiotherapy: comparison of 0.35- and 0.5-mm-diameter computed tomography and magnetic resonance images

Cited by 4 publications

References 8 publications

Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data

Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data

Registration free automatic identification of gold fiducial markers in MRI target delineation images for prostate radiotherapy

Comparison of MRI visualization between linearly placed iron-containing and non-iron-containing fiducial markers for prostate radiotherapy

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