Field Application of a Combined Vaccine against Peste Des Petits Ruminants and Sheep Pox

Abstract

A combined vaccine against peste des petits ruminants (PPR) and sheep/goat pox (SGP), based on Nigeria 75 PPR strain and sheep pox Romania strain, was developed and applied in the field. Safety and efficacy were evaluated on goats and sheep in comparison with monovalent PPR and SGP vaccines. Goats were challenged by PPR virulent strain and sheep by SP virulent strain. The result showsthat the combined PPR/SGP vaccine confers a good protection against both PPR and SGP infection with no significant difference with monovalent vaccines. The combined vaccine was used in Morocco and other African countries on small ruminant flocks with good safety and satisfactory sero-conversion detected against both PPR and SGP viruses, as soon as 14 days post vaccination. It's the first time where a combined vaccine was applied in large vaccination campaigns to prevent in one shot the two diseases.