Fifteen years' experience with staphylococcus septicemia in a large city hospital

Wilson, Rodman; Hamburger, Morton

doi:10.1016/0002-9343(57)90099-2

Cited by 125 publications

(16 citation statements)

References 42 publications

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“…In the 1950s, before the days of trans-oesophageal echocardiography, the rates of infective endocarditis in the context of SAB were noted to be as high as 64% and the recommendation was to treat all cases with a minimum of 4e6 weeks of intravenous antibiotics. 3,4 It has since been argued that shorter courses are safe in intravenous catheter related infections where the catheter is removed and the risks of deep tissue infection are deemed low. 5,6 Even though the only meta-analysis of the published evidence failed to support this position, 3 it has become common practice to use short course therapy (1e2 weeks) in some circumstances.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for recurrence after Staphylococcus aureus bacteraemia. A retrospective matched case–control study

Walker

Bowler

Bejon

2009

Journal of Infection

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Section: Introductionmentioning

confidence: 99%

Risk factors for recurrence after Staphylococcus aureus bacteraemia. A retrospective matched case–control study

Walker

Bowler

Bejon

2009

Journal of Infection

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“…The morbidity and mortality of serious infections due to Staphylococcus aureus, such as septicemia and endocarditis, remain high despite the availability of antibiotics (7,12,13). Before methicillin was introduced, antibiotic combinations were often used to treat such serious staphylococcal infections (13).…”

mentioning

confidence: 99%

“…Before methicillin was introduced, antibiotic combinations were often used to treat such serious staphylococcal infections (13). Since the semisynthetic penicillinase-resistant penicillins and cephalosporins became available, these antibiotics alone have been recommended by many authorities and generally accepted as the therapy of choice for serious infections due to penicillin-resistant S. aureus (3,4,6).…”

mentioning

confidence: 99%

Enhancement of the Effects of Anti-Staphylococcal Antibiotics by Aminoglycosides

Watanakunakorn

Glotzbecker

1974

Antimicrob Agents Chemother

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The in vitro activity of seven anti-staphylococcal antibiotics alone and in combination with four aminoglycoside antibiotics against 35 clinical isolates of Staphylococcus aureus from blood cultures of patients with endocarditis or septicemia was studied. The combination of nafcillin-gentamicin or nafcillin-tobramycin when compared with nafcillin alone killed significantly more S. aureus at 6 h for 33 of 35 isolates. A significant decrease in viable colony-forming units at 24 and 48 h was demonstrated for a smaller number of isolates. Using the agar dilution antibiotic susceptibility test, significant enhancement of activity was demonstrated against almost all isolates when cephalothin, cefazolin, or clindamycin was combined with gentamicin, tobramycin, or kanamycin. The combination of nafcillin or vancomycin with gentamicin, tobramycin, or kanamycin also showed enhanced activity against the majority of isolates. Oxacillin or methicillin when combined with the aminoglycosides showed enhancement of activity against the least number of isolates. Streptomycin was the least effective of the four aminoglycoside antibiotics studied.

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“…In contrast to other reports, 2 of our patients presented with osteomyelitis clinic ally and radiologically. Wilson and Hamburger [12] reported only 1 case of osteomyelitis among 55 cases of septicemia due to S. aureus in a general hospital and Nolan and Beaty [ 13] reported no episodes in 105 cases of bacteremia due to S. aureus.…”

Section: Discussionmentioning

confidence: 99%

<i>Staphylococcus aureus</i> Bacteremia in Children and Adolescents with Acute Lymphoblastic Leukemia

Grossi¹,

Green²

1983

Oncology

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37 episodes of Staphylococcus aureus bacteremia (SAB) in children and adolescents with acute lymphoblastic leukemia (ALL) were analyzed. 25 were associated with an identifiable source of infection: pneumonia (9), cellulitis (11), osteomyelitis (2), ear infection (2), urinary tract infection (1). The absolute neutrophil count was less than 1,000/mm³ at the onset of 29 episodes. 6 patients had a bacterial re-infection after the treatment for SAB was stopped. 5 patients had fungal infection discovered at autopsy. 7 patients died within 4 days of admission. Gram-negative superinfection occurred in 6 patients treated with multiple antibiotics whereas no patient among those treated with a single antibiotic developed superinfection. This was not a statistically different difference.

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Fifteen years' experience with staphylococcus septicemia in a large city hospital

Cited by 125 publications

References 42 publications

Risk factors for recurrence after Staphylococcus aureus bacteraemia. A retrospective matched case–control study

Risk factors for recurrence after Staphylococcus aureus bacteraemia. A retrospective matched case–control study

Enhancement of the Effects of Anti-Staphylococcal Antibiotics by Aminoglycosides

<i>Staphylococcus aureus</i> Bacteremia in Children and Adolescents with Acute Lymphoblastic Leukemia

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