FIGURE 5 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Abstract

<p>Activated and suppressed pathways identified by GSEA using the hallmark gene set in immune subtypes. <b>A</b> and <b>B,</b> Heat maps representing top scored pathways enriched in genes with expression increased and decreased in common in LUAD (A) and LUSQ (B). <b>C</b> and <b>D,</b> Top signatures of pathways with increased expression are shown in red; those for genes with decreased expression are shown in blue. Running enrichment scores for glycolysis, IFNα, IFNγ, K-<i>ras</i> signaling, and TGFβ signaling signatures as commonly activated pathways in immune subtypes of LUAD (C) and LUSQ (D).</p>