Filling the gap between the heart and the body in acromegaly: a case-control study

Ságová, Ivana; Dragula, Milan; Mokáň, Marián; Vaňuga, Peter

doi:10.1007/s12020-022-03232-3

Cited by 5 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an animal study, 6 out of 11 cats with acromegaly showed enlarged LA [22]. Human studies confirmed the dilation of LA in acromegaly patients with and without heart failure [1,6,7,23,28,30]. LA volume index was higher in acromegaly patients [30].…”

Section: In Acromegalymentioning

confidence: 84%

See 1 more Smart Citation

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Nemes,

Kormányos,

Ambrus

et al. 2023

JCM

View full text Add to dashboard Cite

Acromegaly is an uncommon systematic endocrine disease caused by the hypersecretion of human growth hormone and, consequently, of insulin-like growth factor-1 during adulthood. Acromegaly could cause a typical cardiomyopathy characterized by left ventricular hypertrophy associated with diastolic dysfunction, which later could progress to systolic dysfunction. Moreover, some valvular and vascular abnormalities are also associated with acromegaly. This present review aims to summarize available information regarding acromegaly-associated abnormalities in myocardial, valvular, and vascular structural and functional properties and their relationship to disease activity and treatment options.

show abstract

Section: In Acromegalymentioning

confidence: 84%

“…However, cardiac fibrosis was absent in all patients, irrespective of the estimated duration of the disease [27]. In a recent study, the prevalence of LV hypertrophy in acromegaly patients was 67% (78% concentric, 22% eccentric) [28].…”

Section: In Acromegaly LV Structure Volumes and Hypertrophymentioning

confidence: 87%

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Nemes,

Kormányos,

Ambrus

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…[18]Also, AP-LAD, IVST, LVPWD, and LVMi were higher in acromegaly patients. [3,22] In this study, the percentage of LVMi abnormalities was calculated to be 12.1% and 9.9% in patients with pediatricand adult-onset, while the common echocardiographic abnormalities included valvular regurgitation [23], left atrial enlargement, and enlarged LVEDD. Previously reported abnormalities of cardiac structure in patients with acromegaly mainly focused on ventricular hypertrophy, and descriptions of ventricular enlargement were uncommon.…”

Section: Discussionmentioning

confidence: 99%

Distinct clinical characteristics and prognosis of pediatric-onset GHPA patients compared with adult-onset patients

Zheng,

Yang,

Xiao

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose To explore the clinical characteristics, treatment, and prognosis of growth hormone-secreting pituitary adenoma (GHPA) patients with pediatric-onset, so as to facilitate the clinical management. Methods A retrospective cohort study was carried out between 102 pediatric-onset GHPA patients admitted to our hospital from January 2013 to June 2022 and 204 adult-onset GHPA patients who were randomly matched. Results GHPA with pediatric-onset was predominantly male, associated with higher proportion of genetic syndromes, longer course, and delay on diagnosis. Clinical symptoms of visual field defects and menstrual abnormality were more common. The pediatric-onset group presented with higher growth hormone (GH) nadir during oral glucose tolerance test (OGTT), higher rates of hyperprolactinemia, larger maximum diameter of adenoma, higher rates of optic chiasm compression, suprasellar invasion, and pituitary apoplexy. Hypertension, diabetes, and obstructive sleep apnea-hypopnea syndrome (OSAHS) were more common in the adult-onset group. Echocardiography results were similar between the two groups. The pediatric-onset group owned significantly higher treatment scores and proportions of multimodal therapy modality, more surgical complications, and a higher proportion of ki67 ≥ 3%. There was no significant difference in the final cure rate, but male patients with adult-onset had a worse prognosis. The recurrence rate was also similar between two groups. Hypopituitarism was more prevalent in the pediatric-onset group, while the adult-onset group had a higher rate of combining other tumors. Conclusion The clinical characteristics of pediatric-onset GHPA patients were different from adult-onset patients. Multimodal therapy modalities could help to achieve a cure rate similar to that of adult-onset patients.

show abstract

“…The negative correlation could be explained by the amount of different tissues in the trunk, as the amount of lean trunk mass on average doubles that of the average trunk fat mass ( 59 ). In active acromegaly, acceleration effect of excess GH/IGF-I on anabolism results in additional increase in lean mass, including in trunk ( 60 ). Another cause could be the artefactual effect of the regional presence of the soft tissue on the DXA scan, which could affect TBS values.…”

Section: Discussionmentioning

confidence: 99%

Age, body composition parameters and glycaemic control contribute to trabecular bone score deterioration in acromegaly more than disease activity

Ságová,

Mokáň,

Tonhajzerová

et al. 2023

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

IntroductionImpairment of bone structure in patients with acromegaly (AP) varies independently of bone mineral density (BMD). Body composition parameters, which are altered in patients with acromegaly, are important determinants of bone strength.PurposeThe aim of this study was to examine BMD and lumbar trabecular bone score (TBS) by dual-energy X-ray absorptiometry (DXA) and to assess its relationship with disease activity, age, glucose metabolism, and body composition parameters.MethodsThis cross-sectional prospective study involved 115 patients with acromegaly (70 F, 45 M) and 78 healthy controls (CON) (53 F, 25 M) matched for age, gender, and BMI. Bone mineral density, TBS and body composition parameters were measured using DXA.ResultsAP presented with lower TBS compared to CON (1.2 ± 0.1 v 1.31 ± 0.1, P< 0.001). No significant correlation was observed between IGF-1/GH levels and TBS. Age, glycated haemoglobin, BMI, waist circumference, fat mass, and lean mass negatively correlated with TBS in both sexes. Multiple linear regression analysis of all these parameters revealed age and waist circumference as independent significant predictors of TBS in AP. We did not find difference in BMD (lumbar and femoral sites) between AP and CON nor between active and controlled AP. We observed negative correlation between age and BMD of the femoral neck and total hip (P < 0.001). Testosterone levels in males, BMI, waist circumference, fat mass, and lean mass positively correlated with BMD in AP, with stronger correlation between lean mass and BMD compared to fat mass.ConclusionPatients with acromegaly have lower TBS than controls, confirming impaired bone microarchitecture in acromegaly regardless of BMD. Age, body composition parameters and glucose metabolism contribute to TBS deterioration in AP more than disease activity itself.

show abstract

Filling the gap between the heart and the body in acromegaly: a case-control study

Cited by 5 publications

References 55 publications

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly

Distinct clinical characteristics and prognosis of pediatric-onset GHPA patients compared with adult-onset patients

Age, body composition parameters and glycaemic control contribute to trabecular bone score deterioration in acromegaly more than disease activity

Contact Info

Product

Resources

About