Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone

Villegas, Mercedes; Cid, Alicia Graciela; Briones, Cintia Alejandra; Romero, Analía I.; Pistán, Florencia Alejandra; Gonzo, Elio Emilio; Gottifredi, J.C.; Bermúdez, José Marı́a Ancochea

doi:10.1016/j.jsps.2019.04.004

Cited by 12 publications

(2 citation statements)

References 28 publications

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“…Under this framework, the in vitro dissolution of FBZ samples containing P188 and P407 were modeled using the Lumped model [33,36,37] recently developed and validated [32,38]. This semi-empirical model is based on secondorder kinetics (Equation 1) where the driving force is the difference between the maximum amount of drug that the sample can release (M ∞ )(t → ∞) and the amount release at time t (M t ).…”

Section: Dissolution Data Analysismentioning

confidence: 99%

Dissolution Profiles of Fenbendazole from Binary Solid Dispersions: A Mathematical Approach

et al. 2021

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Aim: Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictable in vivo performance. Materials & methods: Dissolution data of fenbendazole released from the SDs and the control physical mixtures were analyzed using the Lumped mathematical model to estimate the parameters of pharmaceutical relevance. Results: The fit data obtained by Lumped model showed that all SDs have a unique dissolution profile with an error of ±4.1% and an initial release rate 500-times higher than the pure drug, without incidence of drug/polymer ratio or polymer type. Conclusion: The Lumped model helped to understand that the main factor influencing the fenbendazole release was the type formulation (SD or physical mixture), regardless of the type or amount of polymer used.

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Section: Dissolution Data Analysismentioning

confidence: 99%

Dissolution Profiles of Fenbendazole from Binary Solid Dispersions: A Mathematical Approach

et al. 2021

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“…This polyester is close to polypropylene in a number of physicochemical characteristics [11]. It has satisfactory thermal, mechanical, and barrier properties, but these characteristics require significant improvement in the situation when innovative platforms, implants, and devices for the implementation in the diverse areas of human activity based on PHB are designed [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Biocomposites Based on Electrospun Fibers of Poly(3-hydroxybutyrate) and Nanoplatelets of Graphene Oxide: Thermal Characteristics and Segmental Dynamics at Hydrothermal and Ozonation Impact

Karpova,

Olkhov,

Varyan

et al. 2023

Polymers

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In order to create new biodegradable nanocomposites for biomedicine, packaging, and environmentally effective adsorbents, ultra-thin composite fibers consisting of poly(3-hydroxybutyrate) (PHB) and graphene oxide (GO) were obtained by electrospinning. Comprehensive studies of ultrathin fibers combining thermal characteristics, dynamic electron paramagnetic resonance (ESR) probe measurements, and scanning electron microscopy (SEM) were carried out. It is shown that at the addition of 0.05, 0.1, 0.3, and 1% OG, the morphology and geometry of the fibers and their thermal and dynamic characteristics depend on the composite content. The features of the crystalline and amorphous structure of the PHB fibers were investigated by the ESR and DSC methods. For all compositions of PHB/GO, a nonlinear dependence of the correlation time of molecular mobility TEMPO probe (τ) and enthalpy of biopolyether melting (ΔH) is observed. The influence of external factors on the structural-dynamic properties of the composite fiber, such as hydrothermal exposure of samples in aqueous medium at 70 °C and ozonolysis, leads to extreme dependencies of τ and ΔH, which reflect two processes affecting the structure in opposite ways. The plasticizing effect of water leads to thermal destruction of the orientation of the pass-through chains in the amorphous regions of PHB and a subsequent decrease in the crystalline phase, and the aggregation of GO nanoplates into associates, reducing the number of GO-macromolecule contacts, thus increasing segmental mobility, as confirmed by decreasing τ values. The obtained PHB/GO fibrillar composites should find application in the future for the creation of new therapeutic and packaging systems with improved biocompatibility and high-barrier properties.

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Mathematical and Pharmacokinetic Approaches for the Design of New 3D Printing Inks Using Ricobendazole

et al. 2022

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Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone

Abstract: Graphical abstract

Cited by 12 publications

References 28 publications

Dissolution Profiles of Fenbendazole from Binary Solid Dispersions: A Mathematical Approach

Dissolution Profiles of Fenbendazole from Binary Solid Dispersions: A Mathematical Approach

Biocomposites Based on Electrospun Fibers of Poly(3-hydroxybutyrate) and Nanoplatelets of Graphene Oxide: Thermal Characteristics and Segmental Dynamics at Hydrothermal and Ozonation Impact

Mathematical and Pharmacokinetic Approaches for the Design of New 3D Printing Inks Using Ricobendazole

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